8QW1

Human NDPK-C in complex with ADP and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006281	biological_process	DNA repair
A	0006915	biological_process	apoptotic process
A	0008053	biological_process	mitochondrial fusion
A	0009117	biological_process	nucleotide metabolic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019003	molecular_function	GDP binding
A	0030552	molecular_function	cAMP binding
A	0034214	biological_process	protein hexamerization
A	0036064	cellular_component	ciliary basal body
A	0042995	cellular_component	cell projection
A	0043531	molecular_function	ADP binding
A	0046872	molecular_function	metal ion binding
A	0070300	molecular_function	phosphatidic acid binding
A	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
A	1990626	biological_process	mitochondrial outer membrane fusion
B	0000166	molecular_function	nucleotide binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006281	biological_process	DNA repair
B	0006915	biological_process	apoptotic process
B	0008053	biological_process	mitochondrial fusion
B	0009117	biological_process	nucleotide metabolic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019003	molecular_function	GDP binding
B	0030552	molecular_function	cAMP binding
B	0034214	biological_process	protein hexamerization
B	0036064	cellular_component	ciliary basal body
B	0042995	cellular_component	cell projection
B	0043531	molecular_function	ADP binding
B	0046872	molecular_function	metal ion binding
B	0070300	molecular_function	phosphatidic acid binding
B	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
B	1990626	biological_process	mitochondrial outer membrane fusion
C	0000166	molecular_function	nucleotide binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006281	biological_process	DNA repair
C	0006915	biological_process	apoptotic process
C	0008053	biological_process	mitochondrial fusion
C	0009117	biological_process	nucleotide metabolic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019003	molecular_function	GDP binding
C	0030552	molecular_function	cAMP binding
C	0034214	biological_process	protein hexamerization
C	0036064	cellular_component	ciliary basal body
C	0042995	cellular_component	cell projection
C	0043531	molecular_function	ADP binding
C	0046872	molecular_function	metal ion binding
C	0070300	molecular_function	phosphatidic acid binding
C	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
C	1990626	biological_process	mitochondrial outer membrane fusion
D	0000166	molecular_function	nucleotide binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006183	biological_process	GTP biosynthetic process
D	0006228	biological_process	UTP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006281	biological_process	DNA repair
D	0006915	biological_process	apoptotic process
D	0008053	biological_process	mitochondrial fusion
D	0009117	biological_process	nucleotide metabolic process
D	0009142	biological_process	nucleoside triphosphate biosynthetic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019003	molecular_function	GDP binding
D	0030552	molecular_function	cAMP binding
D	0034214	biological_process	protein hexamerization
D	0036064	cellular_component	ciliary basal body
D	0042995	cellular_component	cell projection
D	0043531	molecular_function	ADP binding
D	0046872	molecular_function	metal ion binding
D	0070300	molecular_function	phosphatidic acid binding
D	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
D	1990626	biological_process	mitochondrial outer membrane fusion
E	0000166	molecular_function	nucleotide binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006235	biological_process	dTTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006281	biological_process	DNA repair
E	0006915	biological_process	apoptotic process
E	0008053	biological_process	mitochondrial fusion
E	0009117	biological_process	nucleotide metabolic process
E	0009142	biological_process	nucleoside triphosphate biosynthetic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019003	molecular_function	GDP binding
E	0030552	molecular_function	cAMP binding
E	0034214	biological_process	protein hexamerization
E	0036064	cellular_component	ciliary basal body
E	0042995	cellular_component	cell projection
E	0043531	molecular_function	ADP binding
E	0046872	molecular_function	metal ion binding
E	0070300	molecular_function	phosphatidic acid binding
E	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
E	1990626	biological_process	mitochondrial outer membrane fusion
F	0000166	molecular_function	nucleotide binding
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006183	biological_process	GTP biosynthetic process
F	0006228	biological_process	UTP biosynthetic process
F	0006235	biological_process	dTTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006281	biological_process	DNA repair
F	0006915	biological_process	apoptotic process
F	0008053	biological_process	mitochondrial fusion
F	0009117	biological_process	nucleotide metabolic process
F	0009142	biological_process	nucleoside triphosphate biosynthetic process
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0019003	molecular_function	GDP binding
F	0030552	molecular_function	cAMP binding
F	0034214	biological_process	protein hexamerization
F	0036064	cellular_component	ciliary basal body
F	0042995	cellular_component	cell projection
F	0043531	molecular_function	ADP binding
F	0046872	molecular_function	metal ion binding
F	0070300	molecular_function	phosphatidic acid binding
F	0160204	molecular_function	mitochondrion-mitochondrion outer membrane tether activity
F	1990626	biological_process	mitochondrial outer membrane fusion

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NliHGSDSV

Chain	Residue	Details
A	ASN132-VAL140

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000250|UniProtKB:P22392

Chain	Residue	Details
A	HIS135
B	HIS135
C	HIS135
D	HIS135
E	HIS135
F	HIS135

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269|Ref.5, ECO:0007744|PDB:1ZS6

Chain	Residue	Details
A	LYS29
B	ARG122
B	VAL129
B	ASN132
C	LYS29
C	ARG105
C	THR111
C	ARG122
C	VAL129
C	ASN132
D	LYS29
A	ARG105
D	ARG105
D	THR111
D	ARG122
D	VAL129
D	ASN132
E	LYS29
E	ARG105
E	THR111
E	ARG122
E	VAL129
A	THR111
E	ASN132
F	LYS29
F	ARG105
F	THR111
F	ARG122
F	VAL129
F	ASN132
A	ARG122
A	VAL129
A	ASN132
B	LYS29
B	ARG105
B	THR111

---