8QSL

Cryo-EM structure of human SLC15A4 dimer in outward open state in LMNG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0005290	molecular_function	L-histidine transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006857	biological_process	oligopeptide transport
A	0010008	cellular_component	endosome membrane
A	0015031	biological_process	protein transport
A	0015293	molecular_function	symporter activity
A	0015333	molecular_function	peptide:proton symporter activity
A	0015647	molecular_function	peptidoglycan transmembrane transporter activity
A	0015817	biological_process	histidine transport
A	0015833	biological_process	peptide transport
A	0015835	biological_process	peptidoglycan transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031901	cellular_component	early endosome membrane
A	0033023	biological_process	mast cell homeostasis
A	0034157	biological_process	positive regulation of toll-like receptor 7 signaling pathway
A	0034161	biological_process	positive regulation of toll-like receptor 8 signaling pathway
A	0034165	biological_process	positive regulation of toll-like receptor 9 signaling pathway
A	0035579	cellular_component	specific granule membrane
A	0035672	biological_process	oligopeptide transmembrane transport
A	0036020	cellular_component	endolysosome membrane
A	0045087	biological_process	innate immune response
A	0045089	biological_process	positive regulation of innate immune response
A	0048302	biological_process	regulation of isotype switching to IgG isotypes
A	0055085	biological_process	transmembrane transport
A	0070424	biological_process	regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A	0070430	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
A	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
A	0071916	molecular_function	dipeptide transmembrane transporter activity
A	0089708	biological_process	L-histidine transmembrane export from vacuole
A	0140206	biological_process	dipeptide import across plasma membrane
A	1902600	biological_process	proton transmembrane transport
C	0002376	biological_process	immune system process
C	0005290	molecular_function	L-histidine transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005886	cellular_component	plasma membrane
C	0006857	biological_process	oligopeptide transport
C	0010008	cellular_component	endosome membrane
C	0015031	biological_process	protein transport
C	0015293	molecular_function	symporter activity
C	0015333	molecular_function	peptide:proton symporter activity
C	0015647	molecular_function	peptidoglycan transmembrane transporter activity
C	0015817	biological_process	histidine transport
C	0015833	biological_process	peptide transport
C	0015835	biological_process	peptidoglycan transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0031901	cellular_component	early endosome membrane
C	0033023	biological_process	mast cell homeostasis
C	0034157	biological_process	positive regulation of toll-like receptor 7 signaling pathway
C	0034161	biological_process	positive regulation of toll-like receptor 8 signaling pathway
C	0034165	biological_process	positive regulation of toll-like receptor 9 signaling pathway
C	0035579	cellular_component	specific granule membrane
C	0035672	biological_process	oligopeptide transmembrane transport
C	0036020	cellular_component	endolysosome membrane
C	0045087	biological_process	innate immune response
C	0045089	biological_process	positive regulation of innate immune response
C	0048302	biological_process	regulation of isotype switching to IgG isotypes
C	0055085	biological_process	transmembrane transport
C	0070424	biological_process	regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
C	0070430	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
C	0070434	biological_process	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
C	0071916	molecular_function	dipeptide transmembrane transporter activity
C	0089708	biological_process	L-histidine transmembrane export from vacuole
C	0140206	biological_process	dipeptide import across plasma membrane
C	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GlFfFfSgVGsfVgSGLlalV

Chain	Residue	Details
A	GLY490-VAL510

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site_id	PS01023
Number of Residues	13
Details	PTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FnwFYWsINLGAI

Chain	Residue	Details
A	PHE195-ILE207

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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