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8QS3

Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 23 (1083848)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0022407biological_processregulation of cell-cell adhesion
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0032880biological_processregulation of protein localization
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051715biological_processcytolysis in another organism
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A0141156biological_processcAMP/PKA signal transduction
A0160075biological_processnon-canonical inflammasome complex assembly
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1903829biological_processpositive regulation of protein localization
A2000647biological_processnegative regulation of stem cell proliferation
M0000122biological_processnegative regulation of transcription by RNA polymerase II
M0001836biological_processrelease of cytochrome c from mitochondria
M0003334biological_processkeratinocyte development
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0006469biological_processnegative regulation of protein kinase activity
M0006611biological_processprotein export from nucleus
M0007165biological_processsignal transduction
M0008104biological_processprotein localization
M0008426molecular_functionprotein kinase C inhibitor activity
M0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
M0010482biological_processregulation of epidermal cell division
M0010839biological_processnegative regulation of keratinocyte proliferation
M0019901molecular_functionprotein kinase binding
M0022407biological_processregulation of cell-cell adhesion
M0030216biological_processkeratinocyte differentiation
M0030307biological_processpositive regulation of cell growth
M0031424biological_processkeratinization
M0032880biological_processregulation of protein localization
M0042742biological_processdefense response to bacterium
M0042802molecular_functionidentical protein binding
M0043588biological_processskin development
M0043616biological_processkeratinocyte proliferation
M0045296molecular_functioncadherin binding
M0045606biological_processpositive regulation of epidermal cell differentiation
M0045785biological_processpositive regulation of cell adhesion
M0045824biological_processnegative regulation of innate immune response
M0046827biological_processpositive regulation of protein export from nucleus
M0050815molecular_functionphosphoserine residue binding
M0051219molecular_functionphosphoprotein binding
M0051715biological_processcytolysis in another organism
M0051726biological_processregulation of cell cycle
M0061436biological_processestablishment of skin barrier
M0070062cellular_componentextracellular exosome
M0072089biological_processstem cell proliferation
M0140311molecular_functionprotein sequestering activity
M0141156biological_processcAMP/PKA signal transduction
M0160075biological_processnon-canonical inflammasome complex assembly
M1903077biological_processnegative regulation of protein localization to plasma membrane
M1903829biological_processpositive regulation of protein localization
M2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
AARG56
AARG129
MARG56
MARG129

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER5
MSER5

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
MSER74

236620

PDB entries from 2025-05-28

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