8QQL
Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1) - R312H mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005242 | molecular_function | inward rectifier potassium channel activity |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| B | 0005242 | molecular_function | inward rectifier potassium channel activity |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| C | 0005242 | molecular_function | inward rectifier potassium channel activity |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| D | 0005242 | molecular_function | inward rectifier potassium channel activity |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=M1 => ECO:0000250 |
| Chain | Residue | Details |
| B | ARG82-ILE106 | |
| C | ARG82-ILE106 | |
| D | ARG82-ILE106 | |
| A | ARG82-ILE106 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 116 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA107-SER128 | |
| B | ARG148-ILE156 | |
| C | ALA107-SER128 | |
| C | ARG148-ILE156 | |
| D | ALA107-SER128 | |
| D | ARG148-ILE156 | |
| A | ALA107-SER128 | |
| A | ARG148-ILE156 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | INTRAMEM: Helical; Pore-forming; Name=H5 => ECO:0000250 |
| Chain | Residue | Details |
| B | PHE129-GLN140 | |
| C | PHE129-GLN140 | |
| D | PHE129-GLN140 | |
| A | PHE129-GLN140 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | INTRAMEM: Pore-forming => ECO:0000250 |
| Chain | Residue | Details |
| B | THR141-PHE147 | |
| C | THR141-PHE147 | |
| D | THR141-PHE147 | |
| A | THR141-PHE147 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=M2 => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA157-ALA178 | |
| C | ALA157-ALA178 | |
| D | ALA157-ALA178 | |
| A | ALA157-ALA178 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36149965, ECO:0007744|PDB:7ZDZ |
| Chain | Residue | Details |
| B | ASP255 | |
| C | ASP255 | |
| D | ASP255 | |
| A | ASP255 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | SITE: Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium => ECO:0000250 |
| Chain | Residue | Details |
| B | ASP172 | |
| C | ASP172 | |
| D | ASP172 | |
| A | ASP172 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:19608980 |
| Chain | Residue | Details |
| B | CYS76 | |
| C | CYS76 | |
| D | CYS76 | |
| A | CYS76 |
