8QN1
OPR3 variant - R283D
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR190 | |
| C | TYR190 | |
| B | TYR190 | |
| D | TYR190 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16983071, ECO:0000269|PubMed:19660473 |
| Chain | Residue | Details |
| A | PRO31 | |
| C | GLY321 | |
| B | PRO31 | |
| B | GLY64 | |
| B | GLN106 | |
| B | ARG237 | |
| B | GLY321 | |
| D | PRO31 | |
| D | GLY64 | |
| D | GLN106 | |
| D | ARG237 | |
| A | GLY64 | |
| D | GLY321 | |
| A | GLN106 | |
| A | ARG237 | |
| A | GLY321 | |
| C | PRO31 | |
| C | GLY64 | |
| C | GLN106 | |
| C | ARG237 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS185 | |
| D | HIS185 | |
| D | ASP283 | |
| D | GLY342 | |
| A | ASP283 | |
| A | GLY342 | |
| C | HIS185 | |
| C | ASP283 | |
| C | GLY342 | |
| B | HIS185 | |
| B | ASP283 | |
| B | GLY342 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 697 |
| Chain | Residue | Details |
| A | HIS185 | electrostatic stabiliser |
| A | HIS188 | electrostatic stabiliser |
| A | TYR190 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 697 |
| Chain | Residue | Details |
| C | HIS185 | electrostatic stabiliser |
| C | HIS188 | electrostatic stabiliser |
| C | TYR190 | proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 697 |
| Chain | Residue | Details |
| B | HIS185 | electrostatic stabiliser |
| B | HIS188 | electrostatic stabiliser |
| B | TYR190 | proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 697 |
| Chain | Residue | Details |
| D | HIS185 | electrostatic stabiliser |
| D | HIS188 | electrostatic stabiliser |
| D | TYR190 | proton shuttle (general acid/base) |
