8QMT

Succinic semialdehyde dehydrogenase from E. coli with Q262R substitution and bound NAD+, succinic semialdehyde

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
A	0006099	biological_process	tricarboxylic acid cycle
A	0006527	biological_process	L-arginine catabolic process
A	0009013	molecular_function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
A	0009447	biological_process	putrescine catabolic process
A	0009450	biological_process	gamma-aminobutyric acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0036243	molecular_function	succinate-semialdehyde dehydrogenase (NADP+) activity
A	0042803	molecular_function	protein homodimerization activity
A	0070458	biological_process	cellular detoxification of nitrogen compound
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
B	0006099	biological_process	tricarboxylic acid cycle
B	0006527	biological_process	L-arginine catabolic process
B	0009013	molecular_function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
B	0009447	biological_process	putrescine catabolic process
B	0009450	biological_process	gamma-aminobutyric acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0036243	molecular_function	succinate-semialdehyde dehydrogenase (NADP+) activity
B	0042803	molecular_function	protein homodimerization activity
B	0070458	biological_process	cellular detoxification of nitrogen compound
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
C	0006099	biological_process	tricarboxylic acid cycle
C	0006527	biological_process	L-arginine catabolic process
C	0009013	molecular_function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
C	0009447	biological_process	putrescine catabolic process
C	0009450	biological_process	gamma-aminobutyric acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0036243	molecular_function	succinate-semialdehyde dehydrogenase (NADP+) activity
C	0042803	molecular_function	protein homodimerization activity
C	0070458	biological_process	cellular detoxification of nitrogen compound
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0004777	molecular_function	succinate-semialdehyde dehydrogenase (NAD+) activity
D	0006099	biological_process	tricarboxylic acid cycle
D	0006527	biological_process	L-arginine catabolic process
D	0009013	molecular_function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity
D	0009447	biological_process	putrescine catabolic process
D	0009450	biological_process	gamma-aminobutyric acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0036243	molecular_function	succinate-semialdehyde dehydrogenase (NADP+) activity
D	0042803	molecular_function	protein homodimerization activity
D	0070458	biological_process	cellular detoxification of nitrogen compound

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YrNTGQVCAAAK

Chain	Residue	Details
A	TYR261-LYS272

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	GLU234
B	GLU234
C	GLU234
D	GLU234

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	CYS268
B	CYS268
C	CYS268
D	CYS268

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P25526

Chain	Residue	Details
A	TRP136
B	GLU365
C	TRP136
C	LYS160
C	GLY212
C	LEU235
C	GLU365
D	TRP136
D	LYS160
D	GLY212
D	LEU235
A	LYS160
D	GLU365
A	GLY212
A	LEU235
A	GLU365
B	TRP136
B	LYS160
B	GLY212
B	LEU235

---