8QKV

SWR1-nucleosome complex in configuration 2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000500	cellular_component	RNA polymerase I upstream activating factor complex
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006878	biological_process	intracellular copper ion homeostasis
A	0008823	molecular_function	cupric reductase (NADH) activity
A	0009060	biological_process	aerobic respiration
A	0009303	biological_process	rRNA transcription
A	0030527	molecular_function	structural constituent of chromatin
A	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
A	0043505	cellular_component	CENP-A containing nucleosome
A	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
A	0045943	biological_process	positive regulation of transcription by RNA polymerase I
A	0046982	molecular_function	protein heterodimerization activity
A	0070911	biological_process	global genome nucleotide-excision repair
B	0000500	cellular_component	RNA polymerase I upstream activating factor complex
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006878	biological_process	intracellular copper ion homeostasis
B	0008823	molecular_function	cupric reductase (NADH) activity
B	0009060	biological_process	aerobic respiration
B	0009303	biological_process	rRNA transcription
B	0030527	molecular_function	structural constituent of chromatin
B	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
B	0043505	cellular_component	CENP-A containing nucleosome
B	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
B	0045943	biological_process	positive regulation of transcription by RNA polymerase I
B	0046982	molecular_function	protein heterodimerization activity
B	0070911	biological_process	global genome nucleotide-excision repair
C	0000500	cellular_component	RNA polymerase I upstream activating factor complex
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006355	biological_process	regulation of DNA-templated transcription
C	0030527	molecular_function	structural constituent of chromatin
C	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
C	0042802	molecular_function	identical protein binding
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0046982	molecular_function	protein heterodimerization activity
D	0000500	cellular_component	RNA polymerase I upstream activating factor complex
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0006355	biological_process	regulation of DNA-templated transcription
D	0030527	molecular_function	structural constituent of chromatin
D	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
D	0042802	molecular_function	identical protein binding
D	0045943	biological_process	positive regulation of transcription by RNA polymerase I
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006974	biological_process	DNA damage response
E	0030527	molecular_function	structural constituent of chromatin
E	0031507	biological_process	heterochromatin formation
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006281	biological_process	DNA repair
F	0006325	biological_process	chromatin organization
F	0006974	biological_process	DNA damage response
F	0030527	molecular_function	structural constituent of chromatin
F	0031507	biological_process	heterochromatin formation
F	0046982	molecular_function	protein heterodimerization activity
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006301	biological_process	DNA damage tolerance
G	0006325	biological_process	chromatin organization
G	0006355	biological_process	regulation of DNA-templated transcription
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006301	biological_process	DNA damage tolerance
H	0006325	biological_process	chromatin organization
H	0006355	biological_process	regulation of DNA-templated transcription
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
M	0000166	molecular_function	nucleotide binding
M	0000725	biological_process	recombinational repair
M	0000785	cellular_component	chromatin
M	0000812	cellular_component	Swr1 complex
M	0003677	molecular_function	DNA binding
M	0003678	molecular_function	DNA helicase activity
M	0004386	molecular_function	helicase activity
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005829	cellular_component	cytosol
M	0006325	biological_process	chromatin organization
M	0006338	biological_process	chromatin remodeling
M	0006355	biological_process	regulation of DNA-templated transcription
M	0016787	molecular_function	hydrolase activity
M	0016887	molecular_function	ATP hydrolysis activity
M	0031492	molecular_function	nucleosomal DNA binding
M	0042393	molecular_function	histone binding
M	0045815	biological_process	transcription initiation-coupled chromatin remodeling
M	0060090	molecular_function	molecular adaptor activity
M	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
R	0000785	cellular_component	chromatin
R	0000812	cellular_component	Swr1 complex
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0006325	biological_process	chromatin organization
R	0006338	biological_process	chromatin remodeling
R	0006355	biological_process	regulation of DNA-templated transcription
R	0031491	molecular_function	nucleosome binding
R	0034399	cellular_component	nuclear periphery
S	0000785	cellular_component	chromatin
S	0000812	cellular_component	Swr1 complex
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0006325	biological_process	chromatin organization
S	0006338	biological_process	chromatin remodeling
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006623	biological_process	protein targeting to vacuole
S	0008270	molecular_function	zinc ion binding
S	0031491	molecular_function	nucleosome binding
S	0046872	molecular_function	metal ion binding
T	0000166	molecular_function	nucleotide binding
T	0000492	biological_process	box C/D snoRNP assembly
T	0000785	cellular_component	chromatin
T	0000812	cellular_component	Swr1 complex
T	0003678	molecular_function	DNA helicase activity
T	0004386	molecular_function	helicase activity
T	0005515	molecular_function	protein binding
T	0005524	molecular_function	ATP binding
T	0005634	cellular_component	nucleus
T	0006281	biological_process	DNA repair
T	0006325	biological_process	chromatin organization
T	0006338	biological_process	chromatin remodeling
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006357	biological_process	regulation of transcription by RNA polymerase II
T	0006974	biological_process	DNA damage response
T	0008094	molecular_function	ATP-dependent activity, acting on DNA
T	0016787	molecular_function	hydrolase activity
T	0016887	molecular_function	ATP hydrolysis activity
T	0031011	cellular_component	Ino80 complex
T	0035267	cellular_component	NuA4 histone acetyltransferase complex
T	0043138	molecular_function	3'-5' DNA helicase activity
T	0043139	molecular_function	5'-3' DNA helicase activity
T	0050821	biological_process	protein stabilization
T	0097255	cellular_component	R2TP complex
T	0110078	cellular_component	TTT Hsp90 cochaperone complex
U	0000166	molecular_function	nucleotide binding
U	0000492	biological_process	box C/D snoRNP assembly
U	0000785	cellular_component	chromatin
U	0000812	cellular_component	Swr1 complex
U	0003678	molecular_function	DNA helicase activity
U	0004386	molecular_function	helicase activity
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006281	biological_process	DNA repair
U	0006325	biological_process	chromatin organization
U	0006338	biological_process	chromatin remodeling
U	0006355	biological_process	regulation of DNA-templated transcription
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0006364	biological_process	rRNA processing
U	0006974	biological_process	DNA damage response
U	0008094	molecular_function	ATP-dependent activity, acting on DNA
U	0016787	molecular_function	hydrolase activity
U	0016887	molecular_function	ATP hydrolysis activity
U	0031011	cellular_component	Ino80 complex
U	0035267	cellular_component	NuA4 histone acetyltransferase complex
U	0043138	molecular_function	3'-5' DNA helicase activity
U	0043139	molecular_function	5'-3' DNA helicase activity
U	0050821	biological_process	protein stabilization
U	0097255	cellular_component	R2TP complex
U	0110078	cellular_component	TTT Hsp90 cochaperone complex
V	0000166	molecular_function	nucleotide binding
V	0000492	biological_process	box C/D snoRNP assembly
V	0000785	cellular_component	chromatin
V	0000812	cellular_component	Swr1 complex
V	0003678	molecular_function	DNA helicase activity
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0006281	biological_process	DNA repair
V	0006325	biological_process	chromatin organization
V	0006338	biological_process	chromatin remodeling
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0006974	biological_process	DNA damage response
V	0008094	molecular_function	ATP-dependent activity, acting on DNA
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0031011	cellular_component	Ino80 complex
V	0035267	cellular_component	NuA4 histone acetyltransferase complex
V	0043138	molecular_function	3'-5' DNA helicase activity
V	0043139	molecular_function	5'-3' DNA helicase activity
V	0050821	biological_process	protein stabilization
V	0097255	cellular_component	R2TP complex
V	0110078	cellular_component	TTT Hsp90 cochaperone complex
W	0000166	molecular_function	nucleotide binding
W	0000492	biological_process	box C/D snoRNP assembly
W	0000785	cellular_component	chromatin
W	0000812	cellular_component	Swr1 complex
W	0003678	molecular_function	DNA helicase activity
W	0004386	molecular_function	helicase activity
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0006281	biological_process	DNA repair
W	0006325	biological_process	chromatin organization
W	0006338	biological_process	chromatin remodeling
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006364	biological_process	rRNA processing
W	0006974	biological_process	DNA damage response
W	0008094	molecular_function	ATP-dependent activity, acting on DNA
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0031011	cellular_component	Ino80 complex
W	0035267	cellular_component	NuA4 histone acetyltransferase complex
W	0043138	molecular_function	3'-5' DNA helicase activity
W	0043139	molecular_function	5'-3' DNA helicase activity
W	0050821	biological_process	protein stabilization
W	0097255	cellular_component	R2TP complex
W	0110078	cellular_component	TTT Hsp90 cochaperone complex
X	0000166	molecular_function	nucleotide binding
X	0000492	biological_process	box C/D snoRNP assembly
X	0000785	cellular_component	chromatin
X	0000812	cellular_component	Swr1 complex
X	0003678	molecular_function	DNA helicase activity
X	0004386	molecular_function	helicase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0006281	biological_process	DNA repair
X	0006325	biological_process	chromatin organization
X	0006338	biological_process	chromatin remodeling
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006357	biological_process	regulation of transcription by RNA polymerase II
X	0006974	biological_process	DNA damage response
X	0008094	molecular_function	ATP-dependent activity, acting on DNA
X	0016787	molecular_function	hydrolase activity
X	0016887	molecular_function	ATP hydrolysis activity
X	0031011	cellular_component	Ino80 complex
X	0035267	cellular_component	NuA4 histone acetyltransferase complex
X	0043138	molecular_function	3'-5' DNA helicase activity
X	0043139	molecular_function	5'-3' DNA helicase activity
X	0050821	biological_process	protein stabilization
X	0097255	cellular_component	R2TP complex
X	0110078	cellular_component	TTT Hsp90 cochaperone complex
Y	0000166	molecular_function	nucleotide binding
Y	0000492	biological_process	box C/D snoRNP assembly
Y	0000785	cellular_component	chromatin
Y	0000812	cellular_component	Swr1 complex
Y	0003678	molecular_function	DNA helicase activity
Y	0004386	molecular_function	helicase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006281	biological_process	DNA repair
Y	0006325	biological_process	chromatin organization
Y	0006338	biological_process	chromatin remodeling
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0006364	biological_process	rRNA processing
Y	0006974	biological_process	DNA damage response
Y	0008094	molecular_function	ATP-dependent activity, acting on DNA
Y	0016787	molecular_function	hydrolase activity
Y	0016887	molecular_function	ATP hydrolysis activity
Y	0031011	cellular_component	Ino80 complex
Y	0035267	cellular_component	NuA4 histone acetyltransferase complex
Y	0043138	molecular_function	3'-5' DNA helicase activity
Y	0043139	molecular_function	5'-3' DNA helicase activity
Y	0050821	biological_process	protein stabilization
Y	0097255	cellular_component	R2TP complex
Y	0110078	cellular_component	TTT Hsp90 cochaperone complex

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLtFPV

Chain	Residue	Details
F	ALA22-VAL28

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
C	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
B	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG

Chain	Residue	Details
G	ARG95-GLY117

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
B	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16432255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	77
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	13
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	165
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	33
Details	Zinc finger: {"description":"HIT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00453","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00453","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---