8QJH

Connexin-32 gap junction channel in complex with mefloquine

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCnsVCYD

Chain	Residue	Details
A	CYS53-ASP66

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cdvy.PCpntVDCFVSRP

Chain	Residue	Details
A	CYS168-PRO184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1476
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:2460334

Chain	Residue	Details
A	MET1-ARG22
D	MET1-ARG22
D	ALA96-THR130
D	ARG215-CYS283
E	MET1-ARG22
E	ALA96-THR130
E	ARG215-CYS283
F	MET1-ARG22
F	ALA96-THR130
F	ARG215-CYS283
G	MET1-ARG22
A	ALA96-THR130
G	ALA96-THR130
G	ARG215-CYS283
H	MET1-ARG22
H	ALA96-THR130
H	ARG215-CYS283
I	MET1-ARG22
I	ALA96-THR130
I	ARG215-CYS283
J	MET1-ARG22
J	ALA96-THR130
A	ARG215-CYS283
J	ARG215-CYS283
K	MET1-ARG22
K	ALA96-THR130
K	ARG215-CYS283
L	MET1-ARG22
L	ALA96-THR130
L	ARG215-CYS283
B	MET1-ARG22
B	ALA96-THR130
B	ARG215-CYS283
C	MET1-ARG22
C	ALA96-THR130
C	ARG215-CYS283

---

site_id	SWS_FT_FI2
Number of Residues	1020
Details	TRANSMEM: Helical => ECO:0000305

Chain	Residue	Details
A	VAL23-GLY45
C	LEU76-VAL95
C	LEU131-PHE153
C	VAL192-ILE214
D	VAL23-GLY45
D	LEU76-VAL95
D	LEU131-PHE153
D	VAL192-ILE214
E	VAL23-GLY45
E	LEU76-VAL95
E	LEU131-PHE153
A	LEU76-VAL95
E	VAL192-ILE214
F	VAL23-GLY45
F	LEU76-VAL95
F	LEU131-PHE153
F	VAL192-ILE214
G	VAL23-GLY45
G	LEU76-VAL95
G	LEU131-PHE153
G	VAL192-ILE214
H	VAL23-GLY45
A	LEU131-PHE153
H	LEU76-VAL95
H	LEU131-PHE153
H	VAL192-ILE214
I	VAL23-GLY45
I	LEU76-VAL95
I	LEU131-PHE153
I	VAL192-ILE214
J	VAL23-GLY45
J	LEU76-VAL95
J	LEU131-PHE153
A	VAL192-ILE214
J	VAL192-ILE214
K	VAL23-GLY45
K	LEU76-VAL95
K	LEU131-PHE153
K	VAL192-ILE214
L	VAL23-GLY45
L	LEU76-VAL95
L	LEU131-PHE153
L	VAL192-ILE214
B	VAL23-GLY45
B	LEU76-VAL95
B	LEU131-PHE153
B	VAL192-ILE214
C	VAL23-GLY45

---

site_id	SWS_FT_FI3
Number of Residues	792
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:2460334

Chain	Residue	Details
A	ASP46-ARG75
E	TYR154-THR191
F	ASP46-ARG75
F	TYR154-THR191
G	ASP46-ARG75
G	TYR154-THR191
H	ASP46-ARG75
H	TYR154-THR191
I	ASP46-ARG75
I	TYR154-THR191
J	ASP46-ARG75
A	TYR154-THR191
J	TYR154-THR191
K	ASP46-ARG75
K	TYR154-THR191
L	ASP46-ARG75
L	TYR154-THR191
B	ASP46-ARG75
B	TYR154-THR191
C	ASP46-ARG75
C	TYR154-THR191
D	ASP46-ARG75
D	TYR154-THR191
E	ASP46-ARG75

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08033

Chain	Residue	Details
A	SER233
J	SER233
K	SER233
L	SER233
B	SER233
C	SER233
D	SER233
E	SER233
F	SER233
G	SER233
H	SER233
I	SER233

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER258
D	SER258
D	SER266
D	SER277
E	SER258
E	SER266
E	SER277
F	SER258
F	SER266
F	SER277
G	SER258
A	SER266
G	SER266
G	SER277
H	SER258
H	SER266
H	SER277
I	SER258
I	SER266
I	SER277
J	SER258
J	SER266
A	SER277
J	SER277
K	SER258
K	SER266
K	SER277
L	SER258
L	SER266
L	SER277
B	SER258
B	SER266
B	SER277
C	SER258
C	SER266
C	SER277

---