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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8QFC

UFL1 E3 ligase bound 60S ribosome

Functional Information from GO Data
ChainGOidnamespacecontents
A0002181biological_processcytoplasmic translation
A0003723molecular_functionRNA binding
A0003735molecular_functionstructural constituent of ribosome
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005840cellular_componentribosome
A0005925cellular_componentfocal adhesion
A0006412biological_processtranslation
A0014069cellular_componentpostsynaptic density
A0015934cellular_componentlarge ribosomal subunit
A0016020cellular_componentmembrane
A0022625cellular_componentcytosolic large ribosomal subunit
A0022626cellular_componentcytosolic ribosome
A0045471biological_processresponse to ethanol
A0070062cellular_componentextracellular exosome
A1990904cellular_componentribonucleoprotein complex
B0000077biological_processDNA damage checkpoint signaling
B0000724biological_processdouble-strand break repair via homologous recombination
B0000729biological_processDNA double-strand break processing
B0001649biological_processosteoblast differentiation
B0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
B0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006974biological_processDNA damage response
B0008015biological_processblood circulation
B0008284biological_processpositive regulation of cell population proliferation
B0010468biological_processregulation of gene expression
B0010508biological_processpositive regulation of autophagy
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0019901molecular_functionprotein kinase binding
B0030218biological_processerythrocyte differentiation
B0030330biological_processDNA damage response, signal transduction by p53 class mediator
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031397biological_processnegative regulation of protein ubiquitination
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
B0032790biological_processribosome disassembly
B0032880biological_processregulation of protein localization
B0032991cellular_componentprotein-containing complex
B0033146biological_processregulation of intracellular estrogen receptor signaling pathway
B0034976biological_processresponse to endoplasmic reticulum stress
B0035861cellular_componentsite of double-strand break
B0043005cellular_componentneuron projection
B0043122biological_processregulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044546biological_processNLRP3 inflammasome complex assembly
B0050727biological_processregulation of inflammatory response
B0050821biological_processprotein stabilization
B0050868biological_processnegative regulation of T cell activation
B0050870biological_processpositive regulation of T cell activation
B0060218biological_processhematopoietic stem cell differentiation
B0060252biological_processpositive regulation of glial cell proliferation
B0061666molecular_functionUFM1 ligase activity
B0061709biological_processreticulophagy
B0071568molecular_functionUFM1 transferase activity
B0071569biological_processprotein ufmylation
B0072344biological_processrescue of stalled ribosome
B0140374biological_processantiviral innate immune response
B0140501biological_processpositive regulation of reticulophagy
B1901797biological_processnegative regulation of signal transduction by p53 class mediator
B1902065biological_processresponse to L-glutamate
B1903052biological_processpositive regulation of proteolysis involved in protein catabolic process
B1903895biological_processnegative regulation of IRE1-mediated unfolded protein response
B1990592biological_processprotein K69-linked ufmylation
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0001889biological_processliver development
C0001933biological_processnegative regulation of protein phosphorylation
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0007095biological_processmitotic G2 DNA damage checkpoint signaling
C0007346biological_processregulation of mitotic cell cycle
C0007420biological_processbrain development
C0008015biological_processblood circulation
C0008283biological_processcell population proliferation
C0010921biological_processregulation of phosphatase activity
C0012505cellular_componentendomembrane system
C0016020cellular_componentmembrane
C0019901molecular_functionprotein kinase binding
C0030262biological_processapoptotic nuclear changes
C0030332molecular_functioncyclin binding
C0030968biological_processendoplasmic reticulum unfolded protein response
C0031398biological_processpositive regulation of protein ubiquitination
C0032088biological_processnegative regulation of NF-kappaB transcription factor activity
C0032790biological_processribosome disassembly
C0032991cellular_componentprotein-containing complex
C0034976biological_processresponse to endoplasmic reticulum stress
C0042177biological_processnegative regulation of protein catabolic process
C0043407biological_processnegative regulation of MAP kinase activity
C0044387biological_processnegative regulation of protein kinase activity by regulation of protein phosphorylation
C0044389molecular_functionubiquitin-like protein ligase binding
C0044818biological_processmitotic G2/M transition checkpoint
C0045664biological_processregulation of neuron differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0051019molecular_functionmitogen-activated protein kinase binding
C0051059molecular_functionNF-kappaB binding
C0060318biological_processdefinitive erythrocyte differentiation
C0071569biological_processprotein ufmylation
C0071901biological_processnegative regulation of protein serine/threonine kinase activity
C0072344biological_processrescue of stalled ribosome
C0097371molecular_functionMDM2/MDM4 family protein binding
C0140501biological_processpositive regulation of reticulophagy
C1900182biological_processpositive regulation of protein localization to nucleus
C1901798biological_processpositive regulation of signal transduction by p53 class mediator
C1903052biological_processpositive regulation of proteolysis involved in protein catabolic process
C1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
C2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
D0005515molecular_functionprotein binding
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0008015biological_processblood circulation
D0008284biological_processpositive regulation of cell population proliferation
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0016020cellular_componentmembrane
D0030335biological_processpositive regulation of cell migration
D0031647biological_processregulation of protein stability
D0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032790biological_processribosome disassembly
D0033146biological_processregulation of intracellular estrogen receptor signaling pathway
D0034976biological_processresponse to endoplasmic reticulum stress
D0043066biological_processnegative regulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044389molecular_functionubiquitin-like protein ligase binding
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051216biological_processcartilage development
D0061709biological_processreticulophagy
D0070972biological_processprotein localization to endoplasmic reticulum
D0071569biological_processprotein ufmylation
D0072344biological_processrescue of stalled ribosome
D0140501biological_processpositive regulation of reticulophagy
D0141185molecular_functionUFM1-modified protein reader activity
D1900100biological_processpositive regulation of plasma cell differentiation
D1901800biological_processpositive regulation of proteasomal protein catabolic process
D1902808biological_processpositive regulation of cell cycle G1/S phase transition
D1903052biological_processpositive regulation of proteolysis involved in protein catabolic process
D1903721biological_processpositive regulation of I-kappaB phosphorylation
D1903895biological_processnegative regulation of IRE1-mediated unfolded protein response
D1903898biological_processnegative regulation of PERK-mediated unfolded protein response
D1905552biological_processpositive regulation of protein localization to endoplasmic reticulum
D1990592biological_processprotein K69-linked ufmylation
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0007420biological_processbrain development
E0033146biological_processregulation of intracellular estrogen receptor signaling pathway
E0034976biological_processresponse to endoplasmic reticulum stress
E0042308biological_processnegative regulation of protein import into nucleus
E0043066biological_processnegative regulation of apoptotic process
E0061709biological_processreticulophagy
E0071569biological_processprotein ufmylation
E1990592biological_processprotein K69-linked ufmylation
Functional Information from PROSITE/UniProt
site_idPS01199
Number of Residues20
DetailsRIBOSOMAL_L1 Ribosomal protein L1 signature. IkqIpriLGpgLNKAGkFPS
ChainResidueDetails
AILE117-SER136
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"12962325","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P53026","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P53026","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues194
DetailsRegion: {"description":"Mediates interaction with CDK5RAP3","evidences":[{"source":"UniProtKB","id":"B2GV24","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"PubMed","id":"38377992","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues15
DetailsRegion: {"description":"RPL10a-binding domain (RBD)","evidences":[{"source":"PubMed","id":"38383789","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues44
DetailsDomain: {"description":"PCI"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues14
DetailsMotif: {"description":"UFM1-interacting motif (UFIM)","evidences":[{"source":"PubMed","id":"37595036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38383785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38383789","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues62
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"27926783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20018847","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28128204","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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