Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QBY

Respiratory complex I from Paracoccus denitrificans in MSP2N2 nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0030964	cellular_component	NADH dehydrogenase complex
A	0048038	molecular_function	quinone binding
A	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
A	1902600	biological_process	proton transmembrane transport
B	0005506	molecular_function	iron ion binding
B	0005886	cellular_component	plasma membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0009060	biological_process	aerobic respiration
B	0015990	biological_process	electron transport coupled proton transport
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0005886	cellular_component	plasma membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0048038	molecular_function	quinone binding
C	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
D	0051287	molecular_function	NAD binding
E	0003954	molecular_function	NADH dehydrogenase activity
E	0008324	molecular_function	monoatomic cation transmembrane transporter activity
E	0016491	molecular_function	oxidoreductase activity
E	0022804	molecular_function	active transmembrane transporter activity
E	0031090	cellular_component	organelle membrane
E	0031967	cellular_component	organelle envelope
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0055085	biological_process	transmembrane transport
E	0098655	biological_process	monoatomic cation transmembrane transport
E	0098796	cellular_component	membrane protein complex
E	1902494	cellular_component	catalytic complex
F	0000166	molecular_function	nucleotide binding
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
F	0048038	molecular_function	quinone binding
F	0051287	molecular_function	NAD binding
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009055	molecular_function	electron transfer activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0046872	molecular_function	metal ion binding
G	0048038	molecular_function	quinone binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005886	cellular_component	plasma membrane
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0048038	molecular_function	quinone binding
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005506	molecular_function	iron ion binding
I	0005886	cellular_component	plasma membrane
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0046872	molecular_function	metal ion binding
I	0048038	molecular_function	quinone binding
I	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0048038	molecular_function	quinone binding
J	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
L	0003954	molecular_function	NADH dehydrogenase activity
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0012505	cellular_component	endomembrane system
L	0015990	biological_process	electron transport coupled proton transport
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0042773	biological_process	ATP synthesis coupled electron transport
M	0003954	molecular_function	NADH dehydrogenase activity
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0012505	cellular_component	endomembrane system
M	0015990	biological_process	electron transport coupled proton transport
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0046872	molecular_function	metal ion binding
M	0048039	molecular_function	ubiquinone binding
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0048038	molecular_function	quinone binding
N	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
N	1902600	biological_process	proton transmembrane transport
q	0006979	biological_process	response to oxidative stress
q	0016020	cellular_component	membrane
q	0045271	cellular_component	respiratory chain complex I
Q	0016020	cellular_component	membrane
Q	0022900	biological_process	electron transport chain
Q	0022904	biological_process	respiratory electron transport chain
R	0046872	molecular_function	metal ion binding
t	0004719	molecular_function	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
t	0005737	cellular_component	cytoplasm
t	0008168	molecular_function	methyltransferase activity
t	0016740	molecular_function	transferase activity
t	0032259	biological_process	methylation
t	0036211	biological_process	protein modification process

Functional Information from PROSITE/UniProt

site_id	PS00036
Number of Residues	15
Details	BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. Kpa.RNAmQSGTaRTR

Chain	Residue	Details
Q	LYS7-ARG21

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS64-PRO75
I	CYS103-PRO114

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLmEsR

Chain	Residue	Details
D	LEU63-ARG74

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvfDLFgilfsgHsdlRrIL

Chain	Residue	Details
C	GLU118-LEU139

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsiaGnCRmC

Chain	Residue	Details
G	PRO34-CYS51

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS110-GLN122

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIsCtRCVrF

Chain	Residue	Details
G	ARG157-PHE167

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLES

Chain	Residue	Details
F	GLY167-SER182

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU344-GLY355

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQtFaDALKYIvKE

Chain	Residue	Details
H	GLY57-GLU72

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLVEAEseLVa.G

Chain	Residue	Details
H	PRO217-GLY230

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DgrFSweeveCLGaCtnAP

Chain	Residue	Details
E	ASP127-PRO145

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY135-PRO151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	440
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	30
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01351","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	162
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01350","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01356","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)