Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8Q1B

III2-IV1 respiratory supercomplex from S. pombe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006508	biological_process	proteolysis
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016787	molecular_function	hydrolase activity
A	0017087	cellular_component	mitochondrial processing peptidase complex
A	0046872	molecular_function	metal ion binding
B	0005198	molecular_function	structural molecule activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0016020	cellular_component	membrane
B	0045275	cellular_component	respiratory chain complex III
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0045275	cellular_component	respiratory chain complex III
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0045275	cellular_component	respiratory chain complex III
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0016020	cellular_component	membrane
F	0045275	cellular_component	respiratory chain complex III
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0016020	cellular_component	membrane
G	0045275	cellular_component	respiratory chain complex III
G	1902600	biological_process	proton transmembrane transport
H	0003674	molecular_function	molecular_function
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0016020	cellular_component	membrane
H	0045275	cellular_component	respiratory chain complex III
I	0003674	molecular_function	molecular_function
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0016020	cellular_component	membrane
I	0045275	cellular_component	respiratory chain complex III
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
J	1902600	biological_process	proton transmembrane transport
L	0004222	molecular_function	metalloendopeptidase activity
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006508	biological_process	proteolysis
L	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
L	0008233	molecular_function	peptidase activity
L	0008237	molecular_function	metallopeptidase activity
L	0016787	molecular_function	hydrolase activity
L	0017087	cellular_component	mitochondrial processing peptidase complex
L	0046872	molecular_function	metal ion binding
M	0005198	molecular_function	structural molecule activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
M	0016020	cellular_component	membrane
M	0045275	cellular_component	respiratory chain complex III
M	0046872	molecular_function	metal ion binding
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
O	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0016020	cellular_component	membrane
O	0020037	molecular_function	heme binding
O	0045275	cellular_component	respiratory chain complex III
O	0046872	molecular_function	metal ion binding
O	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	0051536	molecular_function	iron-sulfur cluster binding
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0016020	cellular_component	membrane
Q	0045275	cellular_component	respiratory chain complex III
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0045275	cellular_component	respiratory chain complex III
R	1902600	biological_process	proton transmembrane transport
S	0003674	molecular_function	molecular_function
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0016020	cellular_component	membrane
S	0045275	cellular_component	respiratory chain complex III
T	0003674	molecular_function	molecular_function
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0016020	cellular_component	membrane
T	0045275	cellular_component	respiratory chain complex III
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0016020	cellular_component	membrane
U	0045275	cellular_component	respiratory chain complex III
U	1902600	biological_process	proton transmembrane transport
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0009060	biological_process	aerobic respiration
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0045277	cellular_component	respiratory chain complex IV
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0045277	cellular_component	respiratory chain complex IV
b	0046872	molecular_function	metal ion binding
b	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045277	cellular_component	respiratory chain complex IV
c	1902600	biological_process	proton transmembrane transport
d	0004129	molecular_function	cytochrome-c oxidase activity
d	0005739	cellular_component	mitochondrion
d	0005740	cellular_component	mitochondrial envelope
d	0005743	cellular_component	mitochondrial inner membrane
d	0006119	biological_process	oxidative phosphorylation
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
d	0016020	cellular_component	membrane
d	0045277	cellular_component	respiratory chain complex IV
d	0046872	molecular_function	metal ion binding
d	1902600	biological_process	proton transmembrane transport
e	0004129	molecular_function	cytochrome-c oxidase activity
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0006119	biological_process	oxidative phosphorylation
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0016020	cellular_component	membrane
e	0016491	molecular_function	oxidoreductase activity
e	0045277	cellular_component	respiratory chain complex IV
e	1902600	biological_process	proton transmembrane transport
f	0004129	molecular_function	cytochrome-c oxidase activity
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0006119	biological_process	oxidative phosphorylation
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0016020	cellular_component	membrane
f	0045277	cellular_component	respiratory chain complex IV
f	0046872	molecular_function	metal ion binding
f	1902600	biological_process	proton transmembrane transport
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016020	cellular_component	membrane
g	0016491	molecular_function	oxidoreductase activity
g	0045277	cellular_component	respiratory chain complex IV
g	1902600	biological_process	proton transmembrane transport
h	0004129	molecular_function	cytochrome-c oxidase activity
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0006119	biological_process	oxidative phosphorylation
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
h	0016020	cellular_component	membrane
h	0016491	molecular_function	oxidoreductase activity
h	0045277	cellular_component	respiratory chain complex IV
h	1902600	biological_process	proton transmembrane transport
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016020	cellular_component	membrane
i	0016491	molecular_function	oxidoreductase activity
i	0045277	cellular_component	respiratory chain complex IV
i	1902600	biological_process	proton transmembrane transport
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016020	cellular_component	membrane
j	0045277	cellular_component	respiratory chain complex IV
j	1902600	biological_process	proton transmembrane transport
k	0004129	molecular_function	cytochrome-c oxidase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0006119	biological_process	oxidative phosphorylation
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
k	0016020	cellular_component	membrane
k	0016491	molecular_function	oxidoreductase activity
k	0030234	molecular_function	enzyme regulator activity
k	0045277	cellular_component	respiratory chain complex IV
k	1902600	biological_process	proton transmembrane transport
l	0004129	molecular_function	cytochrome-c oxidase activity
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0016020	cellular_component	membrane
l	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
l	0045277	cellular_component	respiratory chain complex IV
l	0098803	cellular_component	respiratory chain complex
l	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyilimpafgvvshiipslahkpifgkegmlwamlsiallglmvws..HH

Chain	Residue	Details
a	TRP243-HIS297

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswavpslgikcdcipgrlnqvslsidreglfygq......CselCgvlHssM

Chain	Residue	Details
b	VAL180-MET228

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsraetaknnGaAHFLEHLaFkGT

Chain	Residue	Details
A	GLY53-THR76

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. LIWmtvykdklrrCpeCGsvYKL

Chain	Residue	Details
d	LEU130-LEU152

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. LRfKkYpWGDGsKTlFwN

Chain	Residue	Details
k	LEU102-ASN119

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:37939086

Chain	Residue	Details
I	MET1-PHE17
N	PHE76-GLY98
N	THR113-CYS133
N	PHE179-ILE199
N	TYR225-PHE245
N	GLN289-ASP309
N	PHE321-GLY341
N	PHE348-PRO368
T	MET1-PHE17
C	THR113-CYS133
C	PHE179-ILE199
C	TYR225-PHE245
C	GLN289-ASP309
C	PHE321-GLY341
C	PHE348-PRO368
N	PHE32-CYS52

site_id	SWS_FT_FI2
Number of Residues	50
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:37939086

Chain	Residue	Details
I	TYR18-ALA43
T	TYR18-ALA43
C	HIS183
C	HIS197
N	HIS82
N	HIS96
N	HIS183
N	HIS197
a	PRO448

site_id	SWS_FT_FI3
Number of Residues	46
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:37939086

Chain	Residue	Details
I	ASN44-GLU67
T	ASN44-GLU67
a	HIS385

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00628

Chain	Residue	Details
E	CYS172
E	HIS174
E	CYS191
E	HIS194
P	CYS172
P	HIS174
P	CYS191
P	HIS194

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000250\|UniProtKB:P07143

Chain	Residue	Details
D	HIS106
D	MET225
O	HIS106
O	MET225

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)