8PZY

Intracellular leucine aminopeptidase of Pseudomonas aeruginosa PA14 - hexameric assembly with manganese bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0008235	molecular_function	metalloexopeptidase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0004177	molecular_function	aminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0008235	molecular_function	metalloexopeptidase activity
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0004177	molecular_function	aminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0008235	molecular_function	metalloexopeptidase activity
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0004177	molecular_function	aminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0008235	molecular_function	metalloexopeptidase activity
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0004177	molecular_function	aminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0008235	molecular_function	metalloexopeptidase activity
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0004177	molecular_function	aminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0008235	molecular_function	metalloexopeptidase activity
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN367-LEU374

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00181

Chain	Residue	Details
A	LYS299
E	ARG373
F	LYS299
F	ARG373
A	ARG373
B	LYS299
B	ARG373
C	LYS299
C	ARG373
D	LYS299
D	ARG373
E	LYS299

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site_id	SWS_FT_FI2
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00181

Chain	Residue	Details
A	LYS287
B	GLU371
C	LYS287
C	ASP292
C	ASP310
C	ASP369
C	GLU371
D	LYS287
D	ASP292
D	ASP310
D	ASP369
A	ASP292
D	GLU371
E	LYS287
E	ASP292
E	ASP310
E	ASP369
E	GLU371
F	LYS287
F	ASP292
F	ASP310
F	ASP369
A	ASP310
F	GLU371
A	ASP369
A	GLU371
B	LYS287
B	ASP292
B	ASP310
B	ASP369

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