Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PR2

Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005078	molecular_function	MAP-kinase scaffold activity
C	0005078	molecular_function	MAP-kinase scaffold activity
f	0000166	molecular_function	nucleotide binding
f	0001673	cellular_component	male germ cell nucleus
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005576	cellular_component	extracellular region
f	0005737	cellular_component	cytoplasm
f	0005813	cellular_component	centrosome
f	0005829	cellular_component	cytosol
f	0005856	cellular_component	cytoskeleton
f	0005868	cellular_component	cytoplasmic dynein complex
f	0005874	cellular_component	microtubule
f	0005881	cellular_component	cytoplasmic microtubule
f	0005938	cellular_component	cell cortex
f	0007018	biological_process	microtubule-based movement
f	0007052	biological_process	mitotic spindle organization
f	0007097	biological_process	nuclear migration
f	0008090	biological_process	retrograde axonal transport
f	0008569	molecular_function	minus-end-directed microtubule motor activity
f	0016020	cellular_component	membrane
f	0030175	cellular_component	filopodium
f	0030286	cellular_component	dynein complex
f	0031122	biological_process	cytoplasmic microtubule organization
f	0032388	biological_process	positive regulation of intracellular transport
f	0033962	biological_process	P-body assembly
f	0034063	biological_process	stress granule assembly
f	0035578	cellular_component	azurophil granule lumen
f	0042802	molecular_function	identical protein binding
f	0045505	molecular_function	dynein intermediate chain binding
f	0051293	biological_process	establishment of spindle localization
f	0051301	biological_process	cell division
f	0051959	molecular_function	dynein light intermediate chain binding
f	0060236	biological_process	regulation of mitotic spindle organization
f	0070062	cellular_component	extracellular exosome
f	0090235	biological_process	regulation of metaphase plate congression
f	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
f	0120162	biological_process	positive regulation of cold-induced thermogenesis
f	1904115	cellular_component	axon cytoplasm
f	1905832	biological_process	positive regulation of spindle assembly
h	0001673	cellular_component	male germ cell nucleus
h	0003777	molecular_function	microtubule motor activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005813	cellular_component	centrosome
h	0005829	cellular_component	cytosol
h	0005856	cellular_component	cytoskeleton
h	0005868	cellular_component	cytoplasmic dynein complex
h	0005874	cellular_component	microtubule
h	0007018	biological_process	microtubule-based movement
h	0010970	biological_process	transport along microtubule
h	0030286	cellular_component	dynein complex
h	0031982	cellular_component	vesicle
h	0032388	biological_process	positive regulation of intracellular transport
h	0045503	molecular_function	dynein light chain binding
h	0045504	molecular_function	dynein heavy chain binding
h	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
j	0000166	molecular_function	nucleotide binding
j	0000226	biological_process	microtubule cytoskeleton organization
j	0000776	cellular_component	kinetochore
j	0001673	cellular_component	male germ cell nucleus
j	0005515	molecular_function	protein binding
j	0005524	molecular_function	ATP binding
j	0005770	cellular_component	late endosome
j	0005813	cellular_component	centrosome
j	0005829	cellular_component	cytosol
j	0005856	cellular_component	cytoskeleton
j	0005868	cellular_component	cytoplasmic dynein complex
j	0005874	cellular_component	microtubule
j	0007018	biological_process	microtubule-based movement
j	0016020	cellular_component	membrane
j	0030286	cellular_component	dynein complex
j	0032388	biological_process	positive regulation of intracellular transport
j	0042802	molecular_function	identical protein binding
j	0045504	molecular_function	dynein heavy chain binding
j	1990090	biological_process	cellular response to nerve growth factor stimulus
m	0000166	molecular_function	nucleotide binding
m	0001673	cellular_component	male germ cell nucleus
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005524	molecular_function	ATP binding
m	0005576	cellular_component	extracellular region
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005829	cellular_component	cytosol
m	0005856	cellular_component	cytoskeleton
m	0005868	cellular_component	cytoplasmic dynein complex
m	0005874	cellular_component	microtubule
m	0005881	cellular_component	cytoplasmic microtubule
m	0005938	cellular_component	cell cortex
m	0007018	biological_process	microtubule-based movement
m	0007052	biological_process	mitotic spindle organization
m	0007097	biological_process	nuclear migration
m	0008090	biological_process	retrograde axonal transport
m	0008569	molecular_function	minus-end-directed microtubule motor activity
m	0016020	cellular_component	membrane
m	0030175	cellular_component	filopodium
m	0030286	cellular_component	dynein complex
m	0031122	biological_process	cytoplasmic microtubule organization
m	0032388	biological_process	positive regulation of intracellular transport
m	0033962	biological_process	P-body assembly
m	0034063	biological_process	stress granule assembly
m	0035578	cellular_component	azurophil granule lumen
m	0042802	molecular_function	identical protein binding
m	0045505	molecular_function	dynein intermediate chain binding
m	0051293	biological_process	establishment of spindle localization
m	0051301	biological_process	cell division
m	0051959	molecular_function	dynein light intermediate chain binding
m	0060236	biological_process	regulation of mitotic spindle organization
m	0070062	cellular_component	extracellular exosome
m	0090235	biological_process	regulation of metaphase plate congression
m	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
m	0120162	biological_process	positive regulation of cold-induced thermogenesis
m	1904115	cellular_component	axon cytoplasm
m	1905832	biological_process	positive regulation of spindle assembly

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
f	ILE2216-SER2226

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	151
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	113
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	49
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	41
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	45
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	39
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)