Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PPR

Structure of the human outer kinetochore KMN network complex

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000444	cellular_component	MIS12/MIND type complex
D	0000776	cellular_component	kinetochore
D	0000922	cellular_component	spindle pole
D	0000940	cellular_component	outer kinetochore
D	0001650	cellular_component	fibrillar center
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0007059	biological_process	chromosome segregation
D	0008608	biological_process	attachment of spindle microtubules to kinetochore
D	0016604	cellular_component	nuclear body
D	0035578	cellular_component	azurophil granule lumen
D	0051301	biological_process	cell division
F	0000776	cellular_component	kinetochore
F	0000940	cellular_component	outer kinetochore
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005829	cellular_component	cytosol
F	0007059	biological_process	chromosome segregation
F	0007094	biological_process	mitotic spindle assembly checkpoint signaling
F	0008017	molecular_function	microtubule binding
F	0008608	biological_process	attachment of spindle microtubules to kinetochore
F	0031262	cellular_component	Ndc80 complex
F	0051301	biological_process	cell division
G	0000776	cellular_component	kinetochore
G	0000940	cellular_component	outer kinetochore
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0007052	biological_process	mitotic spindle organization
G	0007059	biological_process	chromosome segregation
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0008608	biological_process	attachment of spindle microtubules to kinetochore
G	0031262	cellular_component	Ndc80 complex
G	0051301	biological_process	cell division
K	0000070	biological_process	mitotic sister chromatid segregation
K	0000776	cellular_component	kinetochore
K	0000940	cellular_component	outer kinetochore
K	0001669	cellular_component	acrosomal vesicle
K	0001675	biological_process	acrosome assembly
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007059	biological_process	chromosome segregation
K	0008017	molecular_function	microtubule binding
K	0008608	biological_process	attachment of spindle microtubules to kinetochore
K	0016604	cellular_component	nuclear body
K	0031619	biological_process	homologous chromosome orientation in meiotic metaphase I
K	0034501	biological_process	protein localization to kinetochore
K	0051301	biological_process	cell division
K	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
K	0180019	cellular_component	Knl1/Spc105 complex
K	1905326	biological_process	positive regulation of meiosis I spindle assembly checkpoint
M	0000070	biological_process	mitotic sister chromatid segregation
M	0000278	biological_process	mitotic cell cycle
M	0000444	cellular_component	MIS12/MIND type complex
M	0000775	cellular_component	chromosome, centromeric region
M	0000776	cellular_component	kinetochore
M	0000922	cellular_component	spindle pole
M	0000940	cellular_component	outer kinetochore
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005829	cellular_component	cytosol
M	0007059	biological_process	chromosome segregation
M	0008608	biological_process	attachment of spindle microtubules to kinetochore
M	0051301	biological_process	cell division
M	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
M	0051382	biological_process	kinetochore assembly
N	0000070	biological_process	mitotic sister chromatid segregation
N	0000444	cellular_component	MIS12/MIND type complex
N	0000776	cellular_component	kinetochore
N	0000922	cellular_component	spindle pole
N	0000940	cellular_component	outer kinetochore
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005829	cellular_component	cytosol
N	0007059	biological_process	chromosome segregation
N	0008608	biological_process	attachment of spindle microtubules to kinetochore
N	0016607	cellular_component	nuclear speck
N	0051301	biological_process	cell division
P	0000444	cellular_component	MIS12/MIND type complex
P	0000776	cellular_component	kinetochore
P	0000922	cellular_component	spindle pole
P	0000940	cellular_component	outer kinetochore
P	0003713	molecular_function	transcription coactivator activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005667	cellular_component	transcription regulator complex
P	0005829	cellular_component	cytosol
P	0006351	biological_process	DNA-templated transcription
P	0006366	biological_process	transcription by RNA polymerase II
P	0007059	biological_process	chromosome segregation
P	0008608	biological_process	attachment of spindle microtubules to kinetochore
P	0043522	molecular_function	leucine zipper domain binding
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0051301	biological_process	cell division
Z	0000070	biological_process	mitotic sister chromatid segregation
Z	0000776	cellular_component	kinetochore
Z	0000940	cellular_component	outer kinetochore
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0007093	biological_process	mitotic cell cycle checkpoint signaling
Z	0007094	biological_process	mitotic spindle assembly checkpoint signaling
Z	0016604	cellular_component	nuclear body
Z	0030425	cellular_component	dendrite
Z	0031619	biological_process	homologous chromosome orientation in meiotic metaphase I
Z	0051301	biological_process	cell division
Z	0051649	biological_process	establishment of localization in cell
Z	0180019	cellular_component	Knl1/Spc105 complex
Z	1905325	biological_process	regulation of meiosis I spindle assembly checkpoint

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VVLDPPW

Chain	Residue	Details
N	VAL8-TRP14

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	149
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	65
Details	Region: {"description":"Interaction with the C-terminus of SPBC25"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	79
Details	Region: {"description":"Interaction with the C-terminus of SPBC24"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)