8PP7

human RYBP-PRC1 bound to mononucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005700	cellular_component	polytene chromosome
A	0006334	biological_process	nucleosome assembly
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0032991	cellular_component	protein-containing complex
A	0035059	cellular_component	RCAF complex
A	0046982	molecular_function	protein heterodimerization activity
B	0000228	cellular_component	nuclear chromosome
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0035059	cellular_component	RCAF complex
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005700	cellular_component	polytene chromosome
C	0005704	cellular_component	polytene chromosome band
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0007526	biological_process	larval somatic muscle development
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0030527	molecular_function	structural constituent of chromatin
D	0044877	molecular_function	protein-containing complex binding
D	0046982	molecular_function	protein heterodimerization activity
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005700	cellular_component	polytene chromosome
E	0006334	biological_process	nucleosome assembly
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0032991	cellular_component	protein-containing complex
E	0035059	cellular_component	RCAF complex
E	0046982	molecular_function	protein heterodimerization activity
F	0000228	cellular_component	nuclear chromosome
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0035059	cellular_component	RCAF complex
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005700	cellular_component	polytene chromosome
G	0005704	cellular_component	polytene chromosome band
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0007526	biological_process	larval somatic muscle development
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0030527	molecular_function	structural constituent of chromatin
H	0044877	molecular_function	protein-containing complex binding
H	0046982	molecular_function	protein heterodimerization activity
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000151	cellular_component	ubiquitin ligase complex
K	0000785	cellular_component	chromatin
K	0000792	cellular_component	heterochromatin
K	0003682	molecular_function	chromatin binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006351	biological_process	DNA-templated transcription
K	0007379	biological_process	segment specification
K	0008270	molecular_function	zinc ion binding
K	0010468	biological_process	regulation of gene expression
K	0016604	cellular_component	nuclear body
K	0030097	biological_process	hemopoiesis
K	0030890	biological_process	positive regulation of B cell proliferation
K	0031507	biological_process	heterochromatin formation
K	0031519	cellular_component	PcG protein complex
K	0033092	biological_process	positive regulation of immature T cell proliferation in thymus
K	0035102	cellular_component	PRC1 complex
K	0045814	biological_process	negative regulation of gene expression, epigenetic
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding
K	0048146	biological_process	positive regulation of fibroblast proliferation
K	0051443	biological_process	positive regulation of ubiquitin-protein transferase activity
K	0071535	molecular_function	RING-like zinc finger domain binding
K	0097027	molecular_function	ubiquitin-protein transferase activator activity
K	1990841	molecular_function	promoter-specific chromatin binding
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000151	cellular_component	ubiquitin ligase complex
L	0000785	cellular_component	chromatin
L	0000791	cellular_component	euchromatin
L	0000792	cellular_component	heterochromatin
L	0001739	cellular_component	sex chromatin
L	0003682	molecular_function	chromatin binding
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0006338	biological_process	chromatin remodeling
L	0006351	biological_process	DNA-templated transcription
L	0007281	biological_process	germ cell development
L	0008270	molecular_function	zinc ion binding
L	0016567	biological_process	protein ubiquitination
L	0016604	cellular_component	nuclear body
L	0016740	molecular_function	transferase activity
L	0031507	biological_process	heterochromatin formation
L	0031519	cellular_component	PcG protein complex
L	0035102	cellular_component	PRC1 complex
L	0040029	biological_process	epigenetic regulation of gene expression
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0046872	molecular_function	metal ion binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0071339	cellular_component	MLL1 complex
L	0071535	molecular_function	RING-like zinc finger domain binding
L	0140862	molecular_function	histone H2AK119 ubiquitin ligase activity
L	1990904	cellular_component	ribonucleoprotein complex
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000151	cellular_component	ubiquitin ligase complex
M	0000785	cellular_component	chromatin
M	0000792	cellular_component	heterochromatin
M	0003682	molecular_function	chromatin binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0006325	biological_process	chromatin organization
M	0006338	biological_process	chromatin remodeling
M	0006351	biological_process	DNA-templated transcription
M	0007379	biological_process	segment specification
M	0008270	molecular_function	zinc ion binding
M	0010468	biological_process	regulation of gene expression
M	0016604	cellular_component	nuclear body
M	0030097	biological_process	hemopoiesis
M	0030890	biological_process	positive regulation of B cell proliferation
M	0031507	biological_process	heterochromatin formation
M	0031519	cellular_component	PcG protein complex
M	0033092	biological_process	positive regulation of immature T cell proliferation in thymus
M	0035102	cellular_component	PRC1 complex
M	0045814	biological_process	negative regulation of gene expression, epigenetic
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0046872	molecular_function	metal ion binding
M	0048146	biological_process	positive regulation of fibroblast proliferation
M	0051443	biological_process	positive regulation of ubiquitin-protein transferase activity
M	0071535	molecular_function	RING-like zinc finger domain binding
M	0097027	molecular_function	ubiquitin-protein transferase activator activity
M	1990841	molecular_function	promoter-specific chromatin binding
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000151	cellular_component	ubiquitin ligase complex
N	0000785	cellular_component	chromatin
N	0000791	cellular_component	euchromatin
N	0000792	cellular_component	heterochromatin
N	0001739	cellular_component	sex chromatin
N	0003682	molecular_function	chromatin binding
N	0004842	molecular_function	ubiquitin-protein transferase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0006338	biological_process	chromatin remodeling
N	0006351	biological_process	DNA-templated transcription
N	0007281	biological_process	germ cell development
N	0008270	molecular_function	zinc ion binding
N	0016567	biological_process	protein ubiquitination
N	0016604	cellular_component	nuclear body
N	0016740	molecular_function	transferase activity
N	0031507	biological_process	heterochromatin formation
N	0031519	cellular_component	PcG protein complex
N	0035102	cellular_component	PRC1 complex
N	0040029	biological_process	epigenetic regulation of gene expression
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0046872	molecular_function	metal ion binding
N	0061630	molecular_function	ubiquitin protein ligase activity
N	0071339	cellular_component	MLL1 complex
N	0071535	molecular_function	RING-like zinc finger domain binding
N	0140862	molecular_function	histone H2AK119 ubiquitin ligase activity
N	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA20-VAL26

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. ClHrFCadCI

Chain	Residue	Details
L	CYS67-ILE76
K	CYS34-ILE43

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	158
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B","evidences":[{"source":"PubMed","id":"25355358","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25519132","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9CQJ4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"14732680","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18327897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21764853","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18188155","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---