Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8PP6

human RYBP-PRC1 bound to H2AK118ub1 nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005700	cellular_component	polytene chromosome
A	0006334	biological_process	nucleosome assembly
A	0031492	molecular_function	nucleosomal DNA binding
A	0035059	cellular_component	RCAF complex
B	0000228	cellular_component	nuclear chromosome
B	0000786	cellular_component	nucleosome
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0035059	cellular_component	RCAF complex
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005700	cellular_component	polytene chromosome
C	0005704	cellular_component	polytene chromosome band
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0007526	biological_process	larval somatic muscle development
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0044877	molecular_function	protein-containing complex binding
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005700	cellular_component	polytene chromosome
E	0006334	biological_process	nucleosome assembly
E	0031492	molecular_function	nucleosomal DNA binding
E	0035059	cellular_component	RCAF complex
F	0000228	cellular_component	nuclear chromosome
F	0000786	cellular_component	nucleosome
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0035059	cellular_component	RCAF complex
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005700	cellular_component	polytene chromosome
G	0005704	cellular_component	polytene chromosome band
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0007526	biological_process	larval somatic muscle development
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0044877	molecular_function	protein-containing complex binding
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0003676	molecular_function	nucleic acid binding
K	0003677	molecular_function	DNA binding
K	0003712	molecular_function	transcription coregulator activity
K	0003714	molecular_function	transcription corepressor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006915	biological_process	apoptotic process
K	0031519	cellular_component	PcG protein complex
K	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0043065	biological_process	positive regulation of apoptotic process
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA20-VAL26

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
M	LYS27-ASP52

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

site_id	PS01358
Number of Residues	20
Details	ZF_RANBP2_1 Zinc finger RanBP2-type signature. WdCsv..CtfrNsaeafkCsiC

Chain	Residue	Details
K	TRP25-CYS44

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	DNA_BIND:

Chain	Residue	Details
B	LYS16-LYS20
F	LYS16-LYS20

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:16230526

Chain	Residue	Details
B	LYS5
B	LYS12
F	LYS5
F	LYS12
H	LYS113
H	LYS117

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
B	LYS31
E	LYS37
B	LYS77
B	LYS79
B	LYS91
F	LYS31
F	LYS77
F	LYS79
F	LYS91
E	LYS36

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:18327897

Chain	Residue	Details
B	THR80
B	THR82
F	THR80
F	THR82

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:14732680

Chain	Residue	Details
A	LYS18
A	LYS23
E	LYS18
E	LYS23

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS56
E	LYS56

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:22389435

Chain	Residue	Details
A	LYS79
E	LYS79

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)