8PP6

human RYBP-PRC1 bound to H2AK118ub1 nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0005634	cellular_component	nucleus
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005700	cellular_component	polytene chromosome
C	0005704	cellular_component	polytene chromosome band
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0007526	biological_process	larval somatic muscle development
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0044877	molecular_function	protein-containing complex binding
E	0000786	cellular_component	nucleosome
E	0005634	cellular_component	nucleus
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005700	cellular_component	polytene chromosome
G	0005704	cellular_component	polytene chromosome band
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0007526	biological_process	larval somatic muscle development
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0044877	molecular_function	protein-containing complex binding
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0003676	molecular_function	nucleic acid binding
K	0003677	molecular_function	DNA binding
K	0003712	molecular_function	transcription coregulator activity
K	0003714	molecular_function	transcription corepressor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006338	biological_process	chromatin remodeling
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006915	biological_process	apoptotic process
K	0031519	cellular_component	PcG protein complex
K	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0043065	biological_process	positive regulation of apoptotic process
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

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site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
M	LYS27-ASP52

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site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA20-VAL26

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site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

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site_id	PS01358
Number of Residues	20
Details	ZF_RANBP2_1 Zinc finger RanBP2-type signature. WdCsv..CtfrNsaeafkCsiC

Chain	Residue	Details
K	TRP25-CYS44

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	29
Details	ZN_FING: RanBP2-type => ECO:0000255|PROSITE-ProRule:PRU00322

Chain	Residue	Details
K	ASP21-THR50
H	PRO1

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER99
D	LYS113
D	LYS117
H	LYS43
H	LYS113
H	LYS117

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER123
H	SER109

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER127
G	THR119
H	LYS117

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER130
G	LYS118

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
K	SER227

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
K	LYS77

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