Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8PNT

Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000245biological_processspliceosomal complex assembly
A0000339molecular_functionRNA cap binding
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000380biological_processalternative mRNA splicing, via spliceosome
A0000398biological_processmRNA splicing, via spliceosome
A0002191biological_processcap-dependent translational initiation
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005846cellular_componentnuclear cap binding complex
A0006370biological_process7-methylguanosine mRNA capping
A0006397biological_processmRNA processing
A0006401biological_processRNA catabolic process
A0006406biological_processmRNA export from nucleus
A0006408biological_processsnRNA export from nucleus
A0006417biological_processregulation of translation
A0006446biological_processregulation of translational initiation
A0008334biological_processhistone mRNA metabolic process
A0008380biological_processRNA splicing
A0016070biological_processRNA metabolic process
A0016071biological_processmRNA metabolic process
A0030307biological_processpositive regulation of cell growth
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031053biological_processprimary miRNA processing
A0031124biological_processmRNA 3'-end processing
A0031442biological_processpositive regulation of mRNA 3'-end processing
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034518cellular_componentRNA cap binding complex
A0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
A0035195biological_processmiRNA-mediated post-transcriptional gene silencing
A0042789biological_processmRNA transcription by RNA polymerase II
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0050684biological_processregulation of mRNA processing
A0051028biological_processmRNA transport
A0051607biological_processdefense response to virus
A0060090molecular_functionmolecular adaptor activity
A1990904cellular_componentribonucleoprotein complex
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000339molecular_functionRNA cap binding
B0000340molecular_functionRNA 7-methylguanosine cap binding
B0000380biological_processalternative mRNA splicing, via spliceosome
B0000398biological_processmRNA splicing, via spliceosome
B0002191biological_processcap-dependent translational initiation
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005846cellular_componentnuclear cap binding complex
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006408biological_processsnRNA export from nucleus
B0006417biological_processregulation of translation
B0006446biological_processregulation of translational initiation
B0008334biological_processhistone mRNA metabolic process
B0008380biological_processRNA splicing
B0016071biological_processmRNA metabolic process
B0017069molecular_functionsnRNA binding
B0031047biological_processregulatory ncRNA-mediated gene silencing
B0031053biological_processprimary miRNA processing
B0031124biological_processmRNA 3'-end processing
B0031442biological_processpositive regulation of mRNA 3'-end processing
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034518cellular_componentRNA cap binding complex
B0035194biological_processregulatory ncRNA-mediated post-transcriptional gene silencing
B0035195biological_processmiRNA-mediated post-transcriptional gene silencing
B0042789biological_processmRNA transcription by RNA polymerase II
B0045292biological_processmRNA cis splicing, via spliceosome
B0046833biological_processpositive regulation of RNA export from nucleus
B0051028biological_processmRNA transport
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006408biological_processsnRNA export from nucleus
C0015030cellular_componentCajal body
C0015031biological_processprotein transport
C0015643molecular_functiontoxic substance binding
C0043025cellular_componentneuronal cell body
C0043489biological_processRNA stabilization
C0140262molecular_functionmRNA cap binding complex binding
C1990904cellular_componentribonucleoprotein complex
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006408biological_processsnRNA export from nucleus
D0015030cellular_componentCajal body
D0015031biological_processprotein transport
D0015643molecular_functiontoxic substance binding
D0043025cellular_componentneuronal cell body
D0043489biological_processRNA stabilization
D0140262molecular_functionmRNA cap binding complex binding
D1990904cellular_componentribonucleoprotein complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"MIF4G"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues78
DetailsDomain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues10
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12374755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12434151","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues9
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

PDB statisticsPDBj update infoContact PDBjnumon