8PNL

Outward-open conformation of a Major Facilitator Superfamily (MFS) transporter MHAS2168, a homologue of Rv1410 from M. tuberculosis, in complex with an alpaca nanobody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	17
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGRASDRFGRKlliqi.S

Chain	Residue	Details
A	LEU78-SER94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM22","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	212
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=TMA","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=TMB","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	18
Details	Region: {"description":"Beta-hairpin","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Site: {"description":"Protonation/deprotonation site","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Site: {"description":"Forms salt bridge with Arg-426, probably closes bottom of cavity","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Site: {"description":"Forms salt bridge with Gln-157, probably closes bottom of cavity","evidences":[{"source":"PubMed","id":"37833269","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---