8PMD
Nucleotide-bound BSEP in nanodiscs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006699 | biological_process | bile acid biosynthetic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008206 | biological_process | bile acid metabolic process |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009986 | cellular_component | cell surface |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015126 | molecular_function | canalicular bile acid transmembrane transporter activity |
| A | 0015432 | molecular_function | ABC-type bile acid transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015722 | biological_process | canalicular bile acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031998 | biological_process | regulation of fatty acid beta-oxidation |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0046618 | biological_process | xenobiotic export from cell |
| A | 0046691 | cellular_component | intracellular canaliculus |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0055091 | biological_process | phospholipid homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0120189 | biological_process | positive regulation of bile acid secretion |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1904251 | biological_process | regulation of bile acid metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. MSGGQKQRVAIARAL |
| Chain | Residue | Details |
| A | MET559-LEU573 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 952 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-MET62 | |
| A | ARG169-ASP215 | |
| A | SER262-GLY319 | |
| A | ASN375-MET755 | |
| A | GLN816-GLN869 | |
| A | ALA912-ASN979 | |
| A | ARG1033-SER1321 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | PHE63-PHE83 | |
| A | ILE891-LEU911 | |
| A | ILE980-TYR1000 | |
| A | LEU1012-GLY1032 | |
| A | ILE148-ALA168 | |
| A | GLN216-PHE236 | |
| A | LEU241-LEU261 | |
| A | ILE320-ALA340 | |
| A | TYR354-GLY374 | |
| A | LEU756-PHE776 | |
| A | ILE795-LEU815 | |
| A | GLY870-MET890 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 105 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY84-GLY147 | |
| A | ARG237-LYS240 | |
| A | PHE341-GLU353 | |
| A | SER777-GLN794 | |
| A | ARG1001-GLY1011 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY455 | |
| A | GLY1113 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR586 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER587 | |
| A | SER704 | |
| A | SER1214 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QY30 |
| Chain | Residue | Details |
| A | SER690 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70127 |
| Chain | Residue | Details |
| A | SER701 | |
| A | SER1321 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17082223 |
| Chain | Residue | Details |
| A | ASN109 | |
| A | ASN116 | |
| A | ASN122 | |
| A | ASN125 |
