8PKA
Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (without frataxin)
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| C | ASP32-LEU47 |
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDLMsiSGHKiygpk.GvGaI |
| Chain | Residue | Details |
| A | ILE249-ILE268 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:Q9D7P6 |
| Chain | Residue | Details |
| D | CYS69 | |
| B | LYS44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:O29689 |
| Chain | Residue | Details |
| D | CYS138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31101807, ECO:0007744|PDB:6NZU |
| Chain | Residue | Details |
| D | ASP71 | |
| D | CYS95 | |
| D | CYS138 | |
| A | HIS257 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Mediates ISCU dimerization and de novo [2Fe-2S] cluster assembly => ECO:0000269|PubMed:34824239 |
| Chain | Residue | Details |
| D | TYR35 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000250|UniProtKB:Q9D7P6 |
| Chain | Residue | Details |
| D | CYS69 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:24971490 |
| Chain | Residue | Details |
| D | CYS138 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:18650437, ECO:0000305|PubMed:23593335 |
| Chain | Residue | Details |
| A | CYS381 |
