8PK9
Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on NFS1 and ISCU2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016604 | cellular_component | nuclear body |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044571 | biological_process | [2Fe-2S] cluster assembly |
| B | 0044572 | biological_process | [4Fe-4S] cluster assembly |
| B | 0099128 | cellular_component | mitochondrial [2Fe-2S] assembly complex |
| B | 1990221 | cellular_component | L-cysteine desulfurase complex |
| B | 1990229 | cellular_component | iron-sulfur cluster assembly complex |
| C | 0000035 | molecular_function | acyl binding |
| C | 0000036 | molecular_function | acyl carrier activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0008289 | molecular_function | lipid binding |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| C | ASP32-LEU47 |
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDLMsiSGHKiygpk.GvGaI |
| Chain | Residue | Details |
| A | ILE249-ILE268 |
| site_id | PS01344 |
| Number of Residues | 15 |
| Details | FRATAXIN_1 Frataxin family signature. VINKQtPnkQIWlSS |
| Chain | Residue | Details |
| E | VAL144-SER158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:Q9D7P6 |
| Chain | Residue | Details |
| D | CYS69 | |
| B | LYS44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:O29689 |
| Chain | Residue | Details |
| D | CSS138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31101807, ECO:0007744|PDB:6NZU |
| Chain | Residue | Details |
| D | ASP71 | |
| D | CYS95 | |
| D | CSS138 | |
| A | HIS257 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Mediates ISCU dimerization and de novo [2Fe-2S] cluster assembly => ECO:0000269|PubMed:34824239 |
| Chain | Residue | Details |
| D | TYR35 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000250|UniProtKB:Q9D7P6 |
| Chain | Residue | Details |
| D | CYS69 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:24971490 |
| Chain | Residue | Details |
| D | CSS138 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:18650437, ECO:0000305|PubMed:23593335 |
| Chain | Residue | Details |
| A | CSS381 |
