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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8P7C

CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006400biological_processtRNA modification
A0019899molecular_functionenzyme binding
A0030488biological_processtRNA methylation
A0043527cellular_componenttRNA methyltransferase complex
A0052735molecular_functiontRNA (cytidine-N3)-methyltransferase activity
A0106217biological_processtRNA C3-cytosine methylation
B0000049molecular_functiontRNA binding
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000166molecular_functionnucleotide binding
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0001514biological_processselenocysteine incorporation
B0001887biological_processselenium compound metabolic process
B0002181biological_processcytoplasmic translation
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004828molecular_functionserine-tRNA ligase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006400biological_processtRNA modification
B0006412biological_processtranslation
B0006418biological_processtRNA aminoacylation for protein translation
B0006434biological_processseryl-tRNA aminoacylation
B0016525biological_processnegative regulation of angiogenesis
B0019899molecular_functionenzyme binding
B0042803molecular_functionprotein homodimerization activity
B0043527cellular_componenttRNA methyltransferase complex
B0060090molecular_functionmolecular adaptor activity
B0070062cellular_componentextracellular exosome
B0098619molecular_functionselenocysteine-tRNA ligase activity
B0106217biological_processtRNA C3-cytosine methylation
B1904046biological_processnegative regulation of vascular endothelial growth factor production
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0006400biological_processtRNA modification
C0019899molecular_functionenzyme binding
C0030488biological_processtRNA methylation
C0043527cellular_componenttRNA methyltransferase complex
C0052735molecular_functiontRNA (cytidine-N3)-methyltransferase activity
C0106217biological_processtRNA C3-cytosine methylation
D0000049molecular_functiontRNA binding
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0001514biological_processselenocysteine incorporation
D0001887biological_processselenium compound metabolic process
D0002181biological_processcytoplasmic translation
D0004812molecular_functionaminoacyl-tRNA ligase activity
D0004828molecular_functionserine-tRNA ligase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006400biological_processtRNA modification
D0006412biological_processtranslation
D0006418biological_processtRNA aminoacylation for protein translation
D0006434biological_processseryl-tRNA aminoacylation
D0016525biological_processnegative regulation of angiogenesis
D0019899molecular_functionenzyme binding
D0042803molecular_functionprotein homodimerization activity
D0043527cellular_componenttRNA methyltransferase complex
D0060090molecular_functionmolecular adaptor activity
D0070062cellular_componentextracellular exosome
D0098619molecular_functionselenocysteine-tRNA ligase activity
D0106217biological_processtRNA C3-cytosine methylation
D1904046biological_processnegative regulation of vascular endothelial growth factor production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues104
DetailsRegion: {"description":"Interaction with tRNA","evidences":[{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsSite: {"description":"Important for serine binding","evidences":[{"source":"PubMed","id":"28236339","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34922197","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F1E","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34862464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EZG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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