8P5U

Single particle cryo-EM structure of homohexameric 2-oxoglutarate dehydrogenase OdhA from Corynebacterium glutamicum with Coenzyme A bound to the E2o domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
A	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
B	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006099	biological_process	tricarboxylic acid cycle
B	0016491	molecular_function	oxidoreductase activity
B	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
C	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006099	biological_process	tricarboxylic acid cycle
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
D	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006099	biological_process	tricarboxylic acid cycle
D	0016491	molecular_function	oxidoreductase activity
D	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
E	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
F	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006099	biological_process	tricarboxylic acid cycle
F	0016491	molecular_function	oxidoreductase activity
F	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton acceptor; for succinyltransferase activity","evidences":[{"source":"PubMed","id":"20675489","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	90
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A0R2B1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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