8P5R

Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
A	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0008683	molecular_function	2-oxoglutarate decarboxylase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0046872	molecular_function	metal ion binding
A	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
B	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
B	0005829	cellular_component	cytosol
B	0006099	biological_process	tricarboxylic acid cycle
B	0008683	molecular_function	2-oxoglutarate decarboxylase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0046872	molecular_function	metal ion binding
B	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
C	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
C	0005829	cellular_component	cytosol
C	0006099	biological_process	tricarboxylic acid cycle
C	0008683	molecular_function	2-oxoglutarate decarboxylase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0046872	molecular_function	metal ion binding
C	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
D	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
D	0005829	cellular_component	cytosol
D	0006099	biological_process	tricarboxylic acid cycle
D	0008683	molecular_function	2-oxoglutarate decarboxylase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0046872	molecular_function	metal ion binding
D	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
E	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0008683	molecular_function	2-oxoglutarate decarboxylase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0046872	molecular_function	metal ion binding
E	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
F	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
F	0005829	cellular_component	cytosol
F	0006099	biological_process	tricarboxylic acid cycle
F	0008683	molecular_function	2-oxoglutarate decarboxylase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0046872	molecular_function	metal ion binding
F	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
N	0000287	molecular_function	magnesium ion binding
N	0003824	molecular_function	catalytic activity
N	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
N	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
N	0005829	cellular_component	cytosol
N	0006099	biological_process	tricarboxylic acid cycle
N	0008683	molecular_function	2-oxoglutarate decarboxylase activity
N	0016491	molecular_function	oxidoreductase activity
N	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N	0016740	molecular_function	transferase activity
N	0016746	molecular_function	acyltransferase activity
N	0016829	molecular_function	lyase activity
N	0016831	molecular_function	carboxy-lyase activity
N	0030976	molecular_function	thiamine pyrophosphate binding
N	0045252	cellular_component	oxoglutarate dehydrogenase complex
N	0046872	molecular_function	metal ion binding
N	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
O	0000287	molecular_function	magnesium ion binding
O	0003824	molecular_function	catalytic activity
O	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
O	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
O	0005829	cellular_component	cytosol
O	0006099	biological_process	tricarboxylic acid cycle
O	0008683	molecular_function	2-oxoglutarate decarboxylase activity
O	0016491	molecular_function	oxidoreductase activity
O	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O	0016740	molecular_function	transferase activity
O	0016746	molecular_function	acyltransferase activity
O	0016829	molecular_function	lyase activity
O	0016831	molecular_function	carboxy-lyase activity
O	0030976	molecular_function	thiamine pyrophosphate binding
O	0045252	cellular_component	oxoglutarate dehydrogenase complex
O	0046872	molecular_function	metal ion binding
O	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
P	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
P	0005829	cellular_component	cytosol
P	0006099	biological_process	tricarboxylic acid cycle
P	0008683	molecular_function	2-oxoglutarate decarboxylase activity
P	0016491	molecular_function	oxidoreductase activity
P	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P	0016740	molecular_function	transferase activity
P	0016746	molecular_function	acyltransferase activity
P	0016829	molecular_function	lyase activity
P	0016831	molecular_function	carboxy-lyase activity
P	0030976	molecular_function	thiamine pyrophosphate binding
P	0045252	cellular_component	oxoglutarate dehydrogenase complex
P	0046872	molecular_function	metal ion binding
P	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
Q	0000287	molecular_function	magnesium ion binding
Q	0003824	molecular_function	catalytic activity
Q	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Q	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
Q	0005829	cellular_component	cytosol
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0008683	molecular_function	2-oxoglutarate decarboxylase activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Q	0016740	molecular_function	transferase activity
Q	0016746	molecular_function	acyltransferase activity
Q	0016829	molecular_function	lyase activity
Q	0016831	molecular_function	carboxy-lyase activity
Q	0030976	molecular_function	thiamine pyrophosphate binding
Q	0045252	cellular_component	oxoglutarate dehydrogenase complex
Q	0046872	molecular_function	metal ion binding
Q	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	186
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton acceptor; for succinyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	90
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21867916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21867916","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2Y0P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	56
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	294
Details	Domain: {"description":"FHA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00086","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---