Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8P5R

Crystal structure of full-length, homohexameric 2-oxoglutarate dehydrogenase KGD from Mycobacterium smegmatis in complex with GarA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
A	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0008683	molecular_function	2-oxoglutarate decarboxylase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A	0016746	molecular_function	acyltransferase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0046872	molecular_function	metal ion binding
A	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
B	0000287	molecular_function	magnesium ion binding
B	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
B	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
B	0005829	cellular_component	cytosol
B	0006099	biological_process	tricarboxylic acid cycle
B	0008683	molecular_function	2-oxoglutarate decarboxylase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B	0016746	molecular_function	acyltransferase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0030976	molecular_function	thiamine pyrophosphate binding
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0046872	molecular_function	metal ion binding
B	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
C	0000287	molecular_function	magnesium ion binding
C	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
C	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
C	0005829	cellular_component	cytosol
C	0006099	biological_process	tricarboxylic acid cycle
C	0008683	molecular_function	2-oxoglutarate decarboxylase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C	0016746	molecular_function	acyltransferase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0030976	molecular_function	thiamine pyrophosphate binding
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0046872	molecular_function	metal ion binding
C	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
D	0000287	molecular_function	magnesium ion binding
D	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
D	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
D	0005829	cellular_component	cytosol
D	0006099	biological_process	tricarboxylic acid cycle
D	0008683	molecular_function	2-oxoglutarate decarboxylase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D	0016746	molecular_function	acyltransferase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0030976	molecular_function	thiamine pyrophosphate binding
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0046872	molecular_function	metal ion binding
D	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
E	0000287	molecular_function	magnesium ion binding
E	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
E	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0008683	molecular_function	2-oxoglutarate decarboxylase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E	0016746	molecular_function	acyltransferase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0030976	molecular_function	thiamine pyrophosphate binding
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0046872	molecular_function	metal ion binding
E	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
F	0000287	molecular_function	magnesium ion binding
F	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
F	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
F	0005829	cellular_component	cytosol
F	0006099	biological_process	tricarboxylic acid cycle
F	0008683	molecular_function	2-oxoglutarate decarboxylase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F	0016746	molecular_function	acyltransferase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0030976	molecular_function	thiamine pyrophosphate binding
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0046872	molecular_function	metal ion binding
F	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
G	0003729	molecular_function	mRNA binding
H	0003729	molecular_function	mRNA binding
I	0003729	molecular_function	mRNA binding
J	0003729	molecular_function	mRNA binding
K	0003729	molecular_function	mRNA binding
L	0003729	molecular_function	mRNA binding
N	0000287	molecular_function	magnesium ion binding
N	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
N	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
N	0005829	cellular_component	cytosol
N	0006099	biological_process	tricarboxylic acid cycle
N	0008683	molecular_function	2-oxoglutarate decarboxylase activity
N	0016491	molecular_function	oxidoreductase activity
N	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N	0016746	molecular_function	acyltransferase activity
N	0016831	molecular_function	carboxy-lyase activity
N	0030976	molecular_function	thiamine pyrophosphate binding
N	0045252	cellular_component	oxoglutarate dehydrogenase complex
N	0046872	molecular_function	metal ion binding
N	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
O	0000287	molecular_function	magnesium ion binding
O	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
O	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
O	0005829	cellular_component	cytosol
O	0006099	biological_process	tricarboxylic acid cycle
O	0008683	molecular_function	2-oxoglutarate decarboxylase activity
O	0016491	molecular_function	oxidoreductase activity
O	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O	0016746	molecular_function	acyltransferase activity
O	0016831	molecular_function	carboxy-lyase activity
O	0030976	molecular_function	thiamine pyrophosphate binding
O	0045252	cellular_component	oxoglutarate dehydrogenase complex
O	0046872	molecular_function	metal ion binding
O	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
P	0000287	molecular_function	magnesium ion binding
P	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
P	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
P	0005829	cellular_component	cytosol
P	0006099	biological_process	tricarboxylic acid cycle
P	0008683	molecular_function	2-oxoglutarate decarboxylase activity
P	0016491	molecular_function	oxidoreductase activity
P	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P	0016746	molecular_function	acyltransferase activity
P	0016831	molecular_function	carboxy-lyase activity
P	0030976	molecular_function	thiamine pyrophosphate binding
P	0045252	cellular_component	oxoglutarate dehydrogenase complex
P	0046872	molecular_function	metal ion binding
P	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity
Q	0000287	molecular_function	magnesium ion binding
Q	0004149	molecular_function	dihydrolipoyllysine-residue succinyltransferase activity
Q	0004591	molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity
Q	0005829	cellular_component	cytosol
Q	0006099	biological_process	tricarboxylic acid cycle
Q	0008683	molecular_function	2-oxoglutarate decarboxylase activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016624	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Q	0016746	molecular_function	acyltransferase activity
Q	0016831	molecular_function	carboxy-lyase activity
Q	0030976	molecular_function	thiamine pyrophosphate binding
Q	0045252	cellular_component	oxoglutarate dehydrogenase complex
Q	0046872	molecular_function	metal ion binding
Q	0050439	molecular_function	2-hydroxy-3-oxoadipate synthase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by PknG => ECO:0000269\|PubMed:19019160

Chain	Residue	Details
G	THR20
H	THR20
I	THR20
J	THR20
K	THR20
L	THR20
N	HIS314
O	HIS314
P	HIS314
Q	HIS314

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by PknB => ECO:0000250

Chain	Residue	Details
G	THR21
H	THR21
I	THR21
J	THR21
K	THR21
L	THR21
A	ASN678
A	ILE680
A	THR1038
A	ARG1054
A	LYS1089
A	SER1092
A	GLN1142
A	ARG1149
A	ARG1150
B	ARG540
B	SER604
B	LEU606
B	ASP645
B	ALA646
B	ALA647
B	ASN678
B	ILE680
B	THR1038
B	ARG1054
B	LYS1089
B	SER1092
B	GLN1142
B	ARG1149
B	ARG1150
C	ARG540
C	SER604
C	LEU606
C	ASP645
C	ALA646
C	ALA647
C	ASN678
C	ILE680
C	THR1038
C	ARG1054
C	LYS1089
C	SER1092
C	GLN1142
C	ARG1149
C	ARG1150
D	ARG540
D	SER604
D	LEU606
D	ASP645
D	ALA646
D	ALA647
D	ASN678
D	ILE680
D	THR1038
D	ARG1054
D	LYS1089
D	SER1092
D	GLN1142
D	ARG1149
D	ARG1150
E	ARG540
E	SER604
E	LEU606
E	ASP645
E	ALA646
E	ALA647
E	ASN678
E	ILE680
E	THR1038
E	ARG1054
E	LYS1089
E	SER1092
E	GLN1142
E	ARG1149
E	ARG1150
F	ARG540
F	SER604
F	LEU606
F	ASP645
F	ALA646
F	ALA647
F	ASN678
F	ILE680
F	THR1038
F	ARG1054
F	LYS1089
F	SER1092
F	GLN1142
F	ARG1149
F	ARG1150
N	ARG540
N	SER604
N	LEU606
N	ASP645
N	ALA646
N	ALA647
N	ASN678
N	ILE680
N	THR1038
N	ARG1054
N	LYS1089
N	SER1092
N	GLN1142
N	ARG1149
N	ARG1150
O	ARG540
O	SER604
O	LEU606
O	ASP645
O	ALA646
O	ALA647
O	ASN678
O	ILE680
O	THR1038
O	ARG1054
O	LYS1089
O	SER1092
O	GLN1142
O	ARG1149
O	ARG1150
P	ARG540
P	SER604
P	LEU606
P	ASP645
P	ALA646
P	ALA647
P	ASN678
P	ILE680
P	THR1038
P	ARG1054
P	LYS1089
P	SER1092
P	GLN1142
P	ARG1149
P	ARG1150
Q	ARG540
Q	SER604
Q	LEU606
Q	ASP645
Q	ALA646
Q	ALA647
Q	ASN678
Q	ILE680
Q	THR1038
Q	ARG1054
Q	LYS1089
Q	SER1092
Q	GLN1142
Q	ARG1149
Q	ARG1150

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000305\|PubMed:21867916, ECO:0007744\|PDB:2Y0P

Chain	Residue	Details
A	HIS579
A	HIS1020
B	HIS579
B	HIS1020
C	HIS579
C	HIS1020
D	HIS579
D	HIS1020
E	HIS579
E	HIS1020
F	HIS579
F	HIS1020
N	HIS579
N	HIS1020
O	HIS579
O	HIS1020
P	HIS579
P	HIS1020
Q	HIS579
Q	HIS1020

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)