8P3Y

Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005246	molecular_function	calcium channel regulator activity
E	0005262	molecular_function	calcium channel activity
E	0005515	molecular_function	protein binding
E	0005891	cellular_component	voltage-gated calcium channel complex
E	0006612	biological_process	protein targeting to membrane
E	0006816	biological_process	calcium ion transport
E	0007528	biological_process	neuromuscular junction development
E	0009986	cellular_component	cell surface
E	0014069	cellular_component	postsynaptic density
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0019226	biological_process	transmission of nerve impulse
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0034702	cellular_component	monoatomic ion channel complex
E	0035255	molecular_function	ionotropic glutamate receptor binding
E	0036477	cellular_component	somatodendritic compartment
E	0042391	biological_process	regulation of membrane potential
E	0043005	cellular_component	neuron projection
E	0044300	cellular_component	cerebellar mossy fiber
E	0045202	cellular_component	synapse
E	0050877	biological_process	nervous system process
E	0051592	biological_process	response to calcium ion
E	0051899	biological_process	membrane depolarization
E	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
E	0060081	biological_process	membrane hyperpolarization
E	0060082	biological_process	eye blink reflex
E	0070588	biological_process	calcium ion transmembrane transport
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098839	cellular_component	postsynaptic density membrane
E	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
E	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0099590	biological_process	neurotransmitter receptor internalization
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
E	2000311	biological_process	regulation of AMPA receptor activity
F	0005245	molecular_function	voltage-gated calcium channel activity
F	0005246	molecular_function	calcium channel regulator activity
F	0005262	molecular_function	calcium channel activity
F	0005515	molecular_function	protein binding
F	0005891	cellular_component	voltage-gated calcium channel complex
F	0006612	biological_process	protein targeting to membrane
F	0006816	biological_process	calcium ion transport
F	0007528	biological_process	neuromuscular junction development
F	0009986	cellular_component	cell surface
F	0014069	cellular_component	postsynaptic density
F	0016020	cellular_component	membrane
F	0016247	molecular_function	channel regulator activity
F	0019226	biological_process	transmission of nerve impulse
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0034702	cellular_component	monoatomic ion channel complex
F	0035255	molecular_function	ionotropic glutamate receptor binding
F	0036477	cellular_component	somatodendritic compartment
F	0042391	biological_process	regulation of membrane potential
F	0043005	cellular_component	neuron projection
F	0044300	cellular_component	cerebellar mossy fiber
F	0045202	cellular_component	synapse
F	0050877	biological_process	nervous system process
F	0051592	biological_process	response to calcium ion
F	0051899	biological_process	membrane depolarization
F	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
F	0060081	biological_process	membrane hyperpolarization
F	0060082	biological_process	eye blink reflex
F	0070588	biological_process	calcium ion transmembrane transport
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
F	0098839	cellular_component	postsynaptic density membrane
F	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
F	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
F	0098978	cellular_component	glutamatergic synapse
F	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
F	0099590	biological_process	neurotransmitter receptor internalization
F	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
F	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
F	2000311	biological_process	regulation of AMPA receptor activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005246	molecular_function	calcium channel regulator activity
G	0005262	molecular_function	calcium channel activity
G	0005515	molecular_function	protein binding
G	0005891	cellular_component	voltage-gated calcium channel complex
G	0006612	biological_process	protein targeting to membrane
G	0006816	biological_process	calcium ion transport
G	0007528	biological_process	neuromuscular junction development
G	0009986	cellular_component	cell surface
G	0014069	cellular_component	postsynaptic density
G	0016020	cellular_component	membrane
G	0016247	molecular_function	channel regulator activity
G	0019226	biological_process	transmission of nerve impulse
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0034702	cellular_component	monoatomic ion channel complex
G	0035255	molecular_function	ionotropic glutamate receptor binding
G	0036477	cellular_component	somatodendritic compartment
G	0042391	biological_process	regulation of membrane potential
G	0043005	cellular_component	neuron projection
G	0044300	cellular_component	cerebellar mossy fiber
G	0045202	cellular_component	synapse
G	0050877	biological_process	nervous system process
G	0051592	biological_process	response to calcium ion
G	0051899	biological_process	membrane depolarization
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0060081	biological_process	membrane hyperpolarization
G	0060082	biological_process	eye blink reflex
G	0070588	biological_process	calcium ion transmembrane transport
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
G	0098839	cellular_component	postsynaptic density membrane
G	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
G	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	0099590	biological_process	neurotransmitter receptor internalization
G	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
G	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
G	2000311	biological_process	regulation of AMPA receptor activity
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005246	molecular_function	calcium channel regulator activity
H	0005262	molecular_function	calcium channel activity
H	0005515	molecular_function	protein binding
H	0005891	cellular_component	voltage-gated calcium channel complex
H	0006612	biological_process	protein targeting to membrane
H	0006816	biological_process	calcium ion transport
H	0007528	biological_process	neuromuscular junction development
H	0009986	cellular_component	cell surface
H	0014069	cellular_component	postsynaptic density
H	0016020	cellular_component	membrane
H	0016247	molecular_function	channel regulator activity
H	0019226	biological_process	transmission of nerve impulse
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0034702	cellular_component	monoatomic ion channel complex
H	0035255	molecular_function	ionotropic glutamate receptor binding
H	0036477	cellular_component	somatodendritic compartment
H	0042391	biological_process	regulation of membrane potential
H	0043005	cellular_component	neuron projection
H	0044300	cellular_component	cerebellar mossy fiber
H	0045202	cellular_component	synapse
H	0050877	biological_process	nervous system process
H	0051592	biological_process	response to calcium ion
H	0051899	biological_process	membrane depolarization
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0060081	biological_process	membrane hyperpolarization
H	0060082	biological_process	eye blink reflex
H	0070588	biological_process	calcium ion transmembrane transport
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
H	0098839	cellular_component	postsynaptic density membrane
H	0098943	biological_process	neurotransmitter receptor transport, postsynaptic endosome to lysosome
H	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	0099590	biological_process	neurotransmitter receptor internalization
H	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
H	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
H	2000311	biological_process	regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
E	MET10-THR30
E	SER104-ALA124
E	ILE134-ILE154
E	PHE182-ILE202
F	MET10-THR30
F	SER104-ALA124
F	ILE134-ILE154
F	PHE182-ILE202
G	MET10-THR30
G	SER104-ALA124
G	ILE134-ILE154
G	PHE182-ILE202
H	MET10-THR30
H	SER104-ALA124
H	ILE134-ILE154
H	PHE182-ILE202

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
E	SER253
F	SER253
G	SER253
H	SER253
C	ILE525-ARG545
C	GLY598-ALA618
D	ILE525-ARG545
D	GLY598-ALA618

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O88602

Chain	Residue	Details
E	TYR271
F	TYR271
H	TYR271
B	SER592-SER597
C	PHE546-GLY572
C	SER592-SER597
D	PHE546-GLY572
D	SER592-SER597
G	TYR271

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000250|UniProtKB:O88602

Chain	Residue	Details
E	THR321
F	THR321
G	THR321
H	THR321

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN48
F	ASN48
G	ASN48
H	ASN48

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=M4

Chain	Residue	Details
A	GLY794-PHE814
B	GLY794-PHE814
C	GLY794-PHE814
D	GLY794-PHE814

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
A	ALA452
A	GLU487
A	THR707
B	ALA452
B	GLU487
B	THR707
C	ALA452
C	GLU487
C	THR707
D	ALA452
D	GLU487
D	THR707

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	THR480
B	THR480
C	THR480
D	THR480

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	THR482
A	LYS656
A	GLU657
B	THR482
B	LYS656
B	GLU657
C	THR482
C	LYS656
C	GLU657
D	THR482
D	LYS656
D	GLU657

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ALA455
A	SER662
A	SER754
B	ALA455
B	SER662
B	SER754
C	ALA455
C	SER662
C	SER754
D	ALA455
D	SER662
D	SER754

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	SER635
B	SER635
C	SER635
D	SER635

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	ILE664
B	ILE664
C	ILE664
D	ILE664

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	GLY698
B	GLY698
C	GLY698
D	GLY698

---

site_id	SWS_FT_FI14
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819

Chain	Residue	Details
A	ASN841
A	ASN844
A	LYS861
B	ASN841
B	ASN844
B	LYS861
C	ASN841
C	ASN844
C	LYS861
D	ASN841
D	ASN844
D	LYS861

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15240807, ECO:0000269|PubMed:20547133

Chain	Residue	Details
A	ILE857
B	ILE857
C	ILE857
D	ILE857

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	ILE591
A	LYS817
B	ILE591
B	LYS817
C	ILE591
C	LYS817
D	ILE591
D	LYS817

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873

Chain	Residue	Details
A	SER237
B	SER237
C	SER237
D	SER237

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	THR351
B	THR351
C	THR351
D	THR351

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	THR387
A	THR394
B	THR387
B	THR394
C	THR387
C	THR394
D	THR387
D	THR394

---