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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8P2X

Structure of human SIT1:ACE2 complex (open PD conformation)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001618molecular_functionvirus receptor activity
A0001817biological_processregulation of cytokine production
A0002003biological_processangiotensin maturation
A0003051biological_processangiotensin-mediated drinking behavior
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0004181molecular_functionmetallocarboxypeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0009986cellular_componentcell surface
A0015827biological_processtryptophan transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0019058biological_processviral life cycle
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019229biological_processregulation of vasoconstriction
A0030666cellular_componentendocytic vesicle membrane
A0031526cellular_componentbrush border membrane
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0045121cellular_componentmembrane raft
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0046872molecular_functionmetal ion binding
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0051957biological_processpositive regulation of amino acid transport
A0060135biological_processmaternal process involved in female pregnancy
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0097746biological_processblood vessel diameter maintenance
A0098670biological_processentry receptor-mediated virion attachment to host cell
A0141109molecular_functiontransporter activator activity
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1905737biological_processpositive regulation of L-proline import across plasma membrane
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001618molecular_functionvirus receptor activity
B0001817biological_processregulation of cytokine production
B0002003biological_processangiotensin maturation
B0003051biological_processangiotensin-mediated drinking behavior
B0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
B0004175molecular_functionendopeptidase activity
B0004180molecular_functioncarboxypeptidase activity
B0004181molecular_functionmetallocarboxypeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008241molecular_functionpeptidyl-dipeptidase activity
B0008270molecular_functionzinc ion binding
B0009986cellular_componentcell surface
B0015827biological_processtryptophan transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0019058biological_processviral life cycle
B0019065biological_processreceptor-mediated endocytosis of virus by host cell
B0019229biological_processregulation of vasoconstriction
B0030666cellular_componentendocytic vesicle membrane
B0031526cellular_componentbrush border membrane
B0042127biological_processregulation of cell population proliferation
B0042802molecular_functionidentical protein binding
B0045121cellular_componentmembrane raft
B0046718biological_processsymbiont entry into host cell
B0046813biological_processreceptor-mediated virion attachment to host cell
B0046872molecular_functionmetal ion binding
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050727biological_processregulation of inflammatory response
B0051957biological_processpositive regulation of amino acid transport
B0060135biological_processmaternal process involved in female pregnancy
B0060452biological_processpositive regulation of cardiac muscle contraction
B0061025biological_processmembrane fusion
B0070062cellular_componentextracellular exosome
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0097746biological_processblood vessel diameter maintenance
B0098670biological_processentry receptor-mediated virion attachment to host cell
B0141109molecular_functiontransporter activator activity
B1903598biological_processpositive regulation of gap junction assembly
B1903779biological_processregulation of cardiac conduction
B1905737biological_processpositive regulation of L-proline import across plasma membrane
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0005298molecular_functionproline:sodium symporter activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006865biological_processamino acid transport
C0015171molecular_functionamino acid transmembrane transporter activity
C0015175molecular_functionneutral L-amino acid transmembrane transporter activity
C0015188molecular_functionL-isoleucine transmembrane transporter activity
C0015193molecular_functionL-proline transmembrane transporter activity
C0015199molecular_functionamino-acid betaine transmembrane transporter activity
C0015293molecular_functionsymporter activity
C0015370molecular_functionsolute:sodium symporter activity
C0015816biological_processglycine transport
C0015824biological_processproline transport
C0015838biological_processamino-acid betaine transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0022857molecular_functiontransmembrane transporter activity
C0035725biological_processsodium ion transmembrane transport
C0089718biological_processamino acid import across plasma membrane
C0150104biological_processtransport across blood-brain barrier
C1903804biological_processglycine import across plasma membrane
C1903806biological_processL-isoleucine import across plasma membrane
C1904271biological_processL-proline import across plasma membrane
C1905647biological_processproline import across plasma membrane
D0005298molecular_functionproline:sodium symporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006865biological_processamino acid transport
D0015171molecular_functionamino acid transmembrane transporter activity
D0015175molecular_functionneutral L-amino acid transmembrane transporter activity
D0015188molecular_functionL-isoleucine transmembrane transporter activity
D0015193molecular_functionL-proline transmembrane transporter activity
D0015199molecular_functionamino-acid betaine transmembrane transporter activity
D0015293molecular_functionsymporter activity
D0015370molecular_functionsolute:sodium symporter activity
D0015816biological_processglycine transport
D0015824biological_processproline transport
D0015838biological_processamino-acid betaine transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0035725biological_processsodium ion transmembrane transport
D0089718biological_processamino acid import across plasma membrane
D0150104biological_processtransport across blood-brain barrier
D1903804biological_processglycine import across plasma membrane
D1903806biological_processL-isoleucine import across plasma membrane
D1904271biological_processL-proline import across plasma membrane
D1905647biological_processproline import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
ATHR371-GLN380
site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqmYGGGsF
ChainResidueDetails
CTRP29-PHE43
site_idPS00754
Number of Residues21
DetailsNA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfhSFQdpLPWsvCplngNH
ChainResidueDetails
CTYR112-HIS132
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01354","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsRegion: {"description":"Interaction with SARS-CoV spike glycoprotein","evidences":[{"source":"PubMed","id":"15791205","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues14
DetailsRegion: {"description":"Essential for cleavage by ADAM17","evidences":[{"source":"PubMed","id":"24227843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues38
DetailsRegion: {"description":"Essential for cleavage by TMPRSS11D and TMPRSS2","evidences":[{"source":"PubMed","id":"24227843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27217402","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19021774","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues470
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues144
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-11-05

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