8P12
Cryo-EM structure of Rhodopsin-Gi bound to antibody fragment Fab13
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005938 | cellular_component | cell cortex |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0007198 | biological_process | adenylate cyclase-inhibiting serotonin receptor signaling pathway |
| A | 0007218 | biological_process | neuropeptide signaling pathway |
| A | 0010855 | molecular_function | adenylate cyclase inhibitor activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0019003 | molecular_function | GDP binding |
| A | 0030496 | cellular_component | midbody |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| A | 0031749 | molecular_function | D2 dopamine receptor binding |
| A | 0031821 | molecular_function | G protein-coupled serotonin receptor binding |
| A | 0034695 | biological_process | response to prostaglandin E |
| A | 0036064 | cellular_component | ciliary basal body |
| A | 0043303 | biological_process | mast cell degranulation |
| A | 0043434 | biological_process | response to peptide hormone |
| A | 0045542 | biological_process | positive regulation of cholesterol biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0060236 | biological_process | regulation of mitotic spindle organization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070098 | biological_process | chemokine-mediated signaling pathway |
| A | 0072678 | biological_process | T cell migration |
| A | 1901082 | biological_process | positive regulation of relaxation of smooth muscle |
| A | 1903998 | biological_process | regulation of eating behavior |
| A | 1904322 | biological_process | cellular response to forskolin |
| A | 1904778 | biological_process | positive regulation of protein localization to cell cortex |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007165 | biological_process | signal transduction |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0016020 | cellular_component | membrane |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| G | 0097381 | cellular_component | photoreceptor disc membrane |
| R | 0000139 | cellular_component | Golgi membrane |
| R | 0001750 | cellular_component | photoreceptor outer segment |
| R | 0001917 | cellular_component | photoreceptor inner segment |
| R | 0001965 | molecular_function | G-protein alpha-subunit binding |
| R | 0002046 | molecular_function | opsin binding |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| R | 0005502 | molecular_function | 11-cis retinal binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005794 | cellular_component | Golgi apparatus |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0005911 | cellular_component | cell-cell junction |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007601 | biological_process | visual perception |
| R | 0007602 | biological_process | phototransduction |
| R | 0007603 | biological_process | phototransduction, visible light |
| R | 0008020 | molecular_function | G protein-coupled photoreceptor activity |
| R | 0008270 | molecular_function | zinc ion binding |
| R | 0009416 | biological_process | response to light stimulus |
| R | 0009881 | molecular_function | photoreceptor activity |
| R | 0016020 | cellular_component | membrane |
| R | 0016038 | biological_process | absorption of visible light |
| R | 0016056 | biological_process | G protein-coupled opsin signaling pathway |
| R | 0019867 | cellular_component | outer membrane |
| R | 0042622 | cellular_component | photoreceptor outer segment membrane |
| R | 0042802 | molecular_function | identical protein binding |
| R | 0046872 | molecular_function | metal ion binding |
| R | 0060342 | cellular_component | photoreceptor inner segment membrane |
| R | 0071482 | biological_process | cellular response to light stimulus |
| R | 0097225 | cellular_component | sperm midpiece |
| R | 0097381 | cellular_component | photoreceptor disc membrane |
| R | 0097648 | cellular_component | G protein-coupled receptor complex |
| R | 0141190 | biological_process | transducin-mediated opsin signaling pathway |
| R | 1990763 | molecular_function | arrestin family protein binding |
| R | 1990913 | cellular_component | sperm head plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. IALwSLVVLAIERYVvV |
| Chain | Residue | Details |
| R | ILE123-VAL139 |
| site_id | PS00238 |
| Number of Residues | 17 |
| Details | OPSIN Visual pigments (opsins) retinal binding site. IPaFfAKTSAvyNPviY |
| Chain | Residue | Details |
| R | ILE290-TYR306 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR216-HIS222 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 87 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Motif: {"description":"'Ionic lock' involved in activated form stabilization","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Plays an important role in the conformation switch to the active conformation","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-(retinylidene)lysine","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23303210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6870827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TE3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 9 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18434541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22383884","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"PubMed","id":"12486123","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
