8OUE

The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
C	0000495	biological_process	box H/ACA sno(s)RNA 3'-end processing
C	0001522	biological_process	pseudouridine synthesis
C	0001650	cellular_component	fibrillar center
C	0003720	molecular_function	telomerase activity
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005697	cellular_component	telomerase holoenzyme complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0007004	biological_process	telomere maintenance via telomerase
C	0009451	biological_process	RNA modification
C	0009982	molecular_function	pseudouridine synthase activity
C	0015030	cellular_component	Cajal body
C	0016853	molecular_function	isomerase activity
C	0031118	biological_process	rRNA pseudouridine synthesis
C	0031120	biological_process	snRNA pseudouridine synthesis
C	0031429	cellular_component	box H/ACA snoRNP complex
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0033979	biological_process	box H/ACA sno(s)RNA metabolic process
C	0034513	molecular_function	box H/ACA snoRNA binding
C	0042254	biological_process	ribosome biogenesis
C	0070034	molecular_function	telomerase RNA binding
C	0072589	cellular_component	box H/ACA scaRNP complex
C	0090661	cellular_component	box H/ACA telomerase RNP complex
C	0090666	biological_process	scaRNA localization to Cajal body
C	0090669	biological_process	telomerase RNA stabilization
C	1904867	biological_process	protein localization to Cajal body
C	1904872	biological_process	regulation of telomerase RNA localization to Cajal body
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
C	1905323	biological_process	telomerase holoenzyme complex assembly
C	1990481	biological_process	mRNA pseudouridine synthesis
C	1990904	cellular_component	ribonucleoprotein complex
D	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
D	0000781	cellular_component	chromosome, telomeric region
D	0001522	biological_process	pseudouridine synthesis
D	0001650	cellular_component	fibrillar center
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005697	cellular_component	telomerase holoenzyme complex
D	0005730	cellular_component	nucleolus
D	0006364	biological_process	rRNA processing
D	0007004	biological_process	telomere maintenance via telomerase
D	0015030	cellular_component	Cajal body
D	0031429	cellular_component	box H/ACA snoRNP complex
D	0034513	molecular_function	box H/ACA snoRNA binding
D	0042254	biological_process	ribosome biogenesis
D	0070034	molecular_function	telomerase RNA binding
D	0072589	cellular_component	box H/ACA scaRNP complex
D	0090661	cellular_component	box H/ACA telomerase RNP complex
D	1990904	cellular_component	ribonucleoprotein complex
E	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
E	0000781	cellular_component	chromosome, telomeric region
E	0003723	molecular_function	RNA binding
E	0003730	molecular_function	mRNA 3'-UTR binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005697	cellular_component	telomerase holoenzyme complex
E	0005730	cellular_component	nucleolus
E	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
E	0006364	biological_process	rRNA processing
E	0007004	biological_process	telomere maintenance via telomerase
E	0015030	cellular_component	Cajal body
E	0031118	biological_process	rRNA pseudouridine synthesis
E	0031120	biological_process	snRNA pseudouridine synthesis
E	0031429	cellular_component	box H/ACA snoRNP complex
E	0034511	molecular_function	U3 snoRNA binding
E	0034513	molecular_function	box H/ACA snoRNA binding
E	0042254	biological_process	ribosome biogenesis
E	0070034	molecular_function	telomerase RNA binding
E	0072589	cellular_component	box H/ACA scaRNP complex
E	0090661	cellular_component	box H/ACA telomerase RNP complex
E	0090671	biological_process	telomerase RNA localization to Cajal body
E	1990904	cellular_component	ribonucleoprotein complex
F	0001522	biological_process	pseudouridine synthesis
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005697	cellular_component	telomerase holoenzyme complex
F	0005730	cellular_component	nucleolus
F	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
F	0006364	biological_process	rRNA processing
F	0007004	biological_process	telomere maintenance via telomerase
F	0015030	cellular_component	Cajal body
F	0016604	cellular_component	nuclear body
F	0030515	molecular_function	snoRNA binding
F	0031118	biological_process	rRNA pseudouridine synthesis
F	0031120	biological_process	snRNA pseudouridine synthesis
F	0031429	cellular_component	box H/ACA snoRNP complex
F	0034513	molecular_function	box H/ACA snoRNA binding
F	0042254	biological_process	ribosome biogenesis
F	0070034	molecular_function	telomerase RNA binding
F	0072589	cellular_component	box H/ACA scaRNP complex
F	0090661	cellular_component	box H/ACA telomerase RNP complex
F	0090671	biological_process	telomerase RNA localization to Cajal body
F	1990904	cellular_component	ribonucleoprotein complex
G	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
G	0000495	biological_process	box H/ACA sno(s)RNA 3'-end processing
G	0001522	biological_process	pseudouridine synthesis
G	0001650	cellular_component	fibrillar center
G	0003720	molecular_function	telomerase activity
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005697	cellular_component	telomerase holoenzyme complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006364	biological_process	rRNA processing
G	0006396	biological_process	RNA processing
G	0007004	biological_process	telomere maintenance via telomerase
G	0009451	biological_process	RNA modification
G	0009982	molecular_function	pseudouridine synthase activity
G	0015030	cellular_component	Cajal body
G	0016853	molecular_function	isomerase activity
G	0031118	biological_process	rRNA pseudouridine synthesis
G	0031120	biological_process	snRNA pseudouridine synthesis
G	0031429	cellular_component	box H/ACA snoRNP complex
G	0032212	biological_process	positive regulation of telomere maintenance via telomerase
G	0033979	biological_process	box H/ACA sno(s)RNA metabolic process
G	0034513	molecular_function	box H/ACA snoRNA binding
G	0042254	biological_process	ribosome biogenesis
G	0070034	molecular_function	telomerase RNA binding
G	0072589	cellular_component	box H/ACA scaRNP complex
G	0090661	cellular_component	box H/ACA telomerase RNP complex
G	0090666	biological_process	scaRNA localization to Cajal body
G	0090669	biological_process	telomerase RNA stabilization
G	1904867	biological_process	protein localization to Cajal body
G	1904872	biological_process	regulation of telomerase RNA localization to Cajal body
G	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
G	1905323	biological_process	telomerase holoenzyme complex assembly
G	1990481	biological_process	mRNA pseudouridine synthesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
H	0000781	cellular_component	chromosome, telomeric region
H	0001522	biological_process	pseudouridine synthesis
H	0001650	cellular_component	fibrillar center
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005697	cellular_component	telomerase holoenzyme complex
H	0005730	cellular_component	nucleolus
H	0006364	biological_process	rRNA processing
H	0007004	biological_process	telomere maintenance via telomerase
H	0015030	cellular_component	Cajal body
H	0031429	cellular_component	box H/ACA snoRNP complex
H	0034513	molecular_function	box H/ACA snoRNA binding
H	0042254	biological_process	ribosome biogenesis
H	0070034	molecular_function	telomerase RNA binding
H	0072589	cellular_component	box H/ACA scaRNP complex
H	0090661	cellular_component	box H/ACA telomerase RNP complex
H	1990904	cellular_component	ribonucleoprotein complex
I	0000454	biological_process	snoRNA guided rRNA pseudouridine synthesis
I	0000781	cellular_component	chromosome, telomeric region
I	0003723	molecular_function	RNA binding
I	0003730	molecular_function	mRNA 3'-UTR binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005697	cellular_component	telomerase holoenzyme complex
I	0005730	cellular_component	nucleolus
I	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
I	0006364	biological_process	rRNA processing
I	0007004	biological_process	telomere maintenance via telomerase
I	0015030	cellular_component	Cajal body
I	0031118	biological_process	rRNA pseudouridine synthesis
I	0031120	biological_process	snRNA pseudouridine synthesis
I	0031429	cellular_component	box H/ACA snoRNP complex
I	0034511	molecular_function	U3 snoRNA binding
I	0034513	molecular_function	box H/ACA snoRNA binding
I	0042254	biological_process	ribosome biogenesis
I	0070034	molecular_function	telomerase RNA binding
I	0072589	cellular_component	box H/ACA scaRNP complex
I	0090661	cellular_component	box H/ACA telomerase RNP complex
I	0090671	biological_process	telomerase RNA localization to Cajal body
I	1990904	cellular_component	ribonucleoprotein complex
J	0001522	biological_process	pseudouridine synthesis
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005697	cellular_component	telomerase holoenzyme complex
J	0005730	cellular_component	nucleolus
J	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
J	0006364	biological_process	rRNA processing
J	0007004	biological_process	telomere maintenance via telomerase
J	0015030	cellular_component	Cajal body
J	0016604	cellular_component	nuclear body
J	0030515	molecular_function	snoRNA binding
J	0031118	biological_process	rRNA pseudouridine synthesis
J	0031120	biological_process	snRNA pseudouridine synthesis
J	0031429	cellular_component	box H/ACA snoRNP complex
J	0034513	molecular_function	box H/ACA snoRNA binding
J	0042254	biological_process	ribosome biogenesis
J	0070034	molecular_function	telomerase RNA binding
J	0072589	cellular_component	box H/ACA scaRNP complex
J	0090661	cellular_component	box H/ACA telomerase RNP complex
J	0090671	biological_process	telomerase RNA localization to Cajal body
J	1990904	cellular_component	ribonucleoprotein complex
K	0000781	cellular_component	chromosome, telomeric region
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005697	cellular_component	telomerase holoenzyme complex
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006974	biological_process	DNA damage response
K	0007004	biological_process	telomere maintenance via telomerase
K	0015030	cellular_component	Cajal body
K	0016604	cellular_component	nuclear body
K	0030576	biological_process	Cajal body organization
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032203	biological_process	telomere formation via telomerase
K	0032212	biological_process	positive regulation of telomere maintenance via telomerase
K	0034337	biological_process	RNA folding
K	0035861	cellular_component	site of double-strand break
K	0042393	molecular_function	histone binding
K	0042802	molecular_function	identical protein binding
K	0044877	molecular_function	protein-containing complex binding
K	0045739	biological_process	positive regulation of DNA repair
K	0051087	molecular_function	protein-folding chaperone binding
K	0070034	molecular_function	telomerase RNA binding
K	0090666	biological_process	scaRNA localization to Cajal body
K	0090671	biological_process	telomerase RNA localization to Cajal body
K	0140597	molecular_function	protein carrier chaperone
K	0140691	molecular_function	RNA folding chaperone
K	1904851	biological_process	positive regulation of establishment of protein localization to telomere
K	1904867	biological_process	protein localization to Cajal body
K	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
K	2000781	biological_process	positive regulation of double-strand break repair
K	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"PUA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00161","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P60340","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	41
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---