8OO3

X-ray structure of the adduct formed upon reaction of cisplatin with human angiogenin after 5 days soaking

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0001525	biological_process	angiogenesis
AAA	0001541	biological_process	ovarian follicle development
AAA	0001556	biological_process	oocyte maturation
AAA	0001666	biological_process	response to hypoxia
AAA	0001890	biological_process	placenta development
AAA	0001938	biological_process	positive regulation of endothelial cell proliferation
AAA	0002181	biological_process	cytoplasmic translation
AAA	0003676	molecular_function	nucleic acid binding
AAA	0003677	molecular_function	DNA binding
AAA	0003779	molecular_function	actin binding
AAA	0004518	molecular_function	nuclease activity
AAA	0004519	molecular_function	endonuclease activity
AAA	0004521	molecular_function	RNA endonuclease activity
AAA	0004540	molecular_function	RNA nuclease activity
AAA	0004549	molecular_function	tRNA-specific ribonuclease activity
AAA	0005102	molecular_function	signaling receptor binding
AAA	0005507	molecular_function	copper ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005576	cellular_component	extracellular region
AAA	0005604	cellular_component	basement membrane
AAA	0005615	cellular_component	extracellular space
AAA	0005634	cellular_component	nucleus
AAA	0005694	cellular_component	chromosome
AAA	0005730	cellular_component	nucleolus
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006898	biological_process	receptor-mediated endocytosis
AAA	0007154	biological_process	cell communication
AAA	0007165	biological_process	signal transduction
AAA	0008201	molecular_function	heparin binding
AAA	0009303	biological_process	rRNA transcription
AAA	0009725	biological_process	response to hormone
AAA	0010494	cellular_component	cytoplasmic stress granule
AAA	0015629	cellular_component	actin cytoskeleton
AAA	0016078	biological_process	tRNA decay
AAA	0016477	biological_process	cell migration
AAA	0016787	molecular_function	hydrolase activity
AAA	0017148	biological_process	negative regulation of translation
AAA	0019731	biological_process	antibacterial humoral response
AAA	0019843	molecular_function	rRNA binding
AAA	0023052	biological_process	signaling
AAA	0030041	biological_process	actin filament polymerization
AAA	0030139	cellular_component	endocytic vesicle
AAA	0030154	biological_process	cell differentiation
AAA	0030426	cellular_component	growth cone
AAA	0032055	biological_process	negative regulation of translation in response to stress
AAA	0032311	cellular_component	angiogenin-PRI complex
AAA	0033554	biological_process	cellular response to stress
AAA	0034063	biological_process	stress granule assembly
AAA	0036416	biological_process	tRNA stabilization
AAA	0042277	molecular_function	peptide binding
AAA	0042327	biological_process	positive regulation of phosphorylation
AAA	0042592	biological_process	homeostatic process
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0043022	molecular_function	ribosome binding
AAA	0043025	cellular_component	neuronal cell body
AAA	0043066	biological_process	negative regulation of apoptotic process
AAA	0045087	biological_process	innate immune response
AAA	0048018	molecular_function	receptor ligand activity
AAA	0048662	biological_process	negative regulation of smooth muscle cell proliferation
AAA	0050714	biological_process	positive regulation of protein secretion
AAA	0050830	biological_process	defense response to Gram-positive bacterium
AAA	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
AAA	0071425	biological_process	hematopoietic stem cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF

Chain	Residue	Details
AAA	CYS39-PHE45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:38718836, ECO:0000269|PubMed:9918722

Chain	Residue	Details
AAA	HIS13

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:38718836, ECO:0000269|PubMed:9918722

Chain	Residue	Details
AAA	HIS114

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:38718836

Chain	Residue	Details
AAA	ARG21
AAA	ASP22
AAA	CYS81
AAA	VAL103

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2866794

Chain	Residue	Details
AAA	GLN1

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 564

Chain

Residue

Details

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