8KIB
NADP+-dependent cytosolic isocitrate dehydrogenase complexed with oxaloacetate
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NYDGDVqSDsvAqgy.GSLGM |
| Chain | Residue | Details |
| A | ASN271-MET290 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29923039, ECO:0007744|PDB:5YZH, ECO:0007744|PDB:5YZI |
| Chain | Residue | Details |
| A | THR75 | |
| B | ASN328 | |
| C | THR75 | |
| C | ARG82 | |
| C | LYS260 | |
| C | GLY310 | |
| C | ASN328 | |
| D | THR75 | |
| D | ARG82 | |
| D | LYS260 | |
| D | GLY310 | |
| A | ARG82 | |
| D | ASN328 | |
| A | LYS260 | |
| A | GLY310 | |
| A | ASN328 | |
| B | THR75 | |
| B | ARG82 | |
| B | LYS260 | |
| B | GLY310 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:29923039, ECO:0007744|PDB:5YZI |
| Chain | Residue | Details |
| A | THR77 | |
| C | SER94 | |
| C | ARG109 | |
| C | ARG132 | |
| D | THR77 | |
| D | SER94 | |
| D | ARG109 | |
| D | ARG132 | |
| A | SER94 | |
| A | ARG109 | |
| A | ARG132 | |
| B | THR77 | |
| B | SER94 | |
| B | ARG109 | |
| B | ARG132 | |
| C | THR77 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29923039, ECO:0007744|PDB:5YZI |
| Chain | Residue | Details |
| A | LYS212 | |
| B | LYS212 | |
| C | LYS212 | |
| D | LYS212 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:29923039 |
| Chain | Residue | Details |
| A | ASP252 | |
| B | ASP252 | |
| C | ASP252 | |
| D | ASP252 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: in other chain => ECO:0000305|PubMed:29923039 |
| Chain | Residue | Details |
| A | ASP275 | |
| A | ASP279 | |
| B | ASP275 | |
| B | ASP279 | |
| C | ASP275 | |
| C | ASP279 | |
| D | ASP275 | |
| D | ASP279 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | SITE: Critical for catalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR139 | |
| A | LYS212 | |
| B | TYR139 | |
| B | LYS212 | |
| C | TYR139 | |
| C | LYS212 | |
| D | TYR139 | |
| D | LYS212 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:O75874 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 | |
| C | SER2 | |
| D | SER2 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:O75874 |
| Chain | Residue | Details |
| A | TYR42 | |
| B | TYR42 | |
| C | TYR42 | |
| D | TYR42 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23576753 |
| Chain | Residue | Details |
| A | LYS81 | |
| C | LYS224 | |
| C | LYS233 | |
| C | LYS243 | |
| D | LYS81 | |
| D | LYS224 | |
| D | LYS233 | |
| D | LYS243 | |
| A | LYS224 | |
| A | LYS233 | |
| A | LYS243 | |
| B | LYS81 | |
| B | LYS224 | |
| B | LYS233 | |
| B | LYS243 | |
| C | LYS81 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS126 | |
| A | LYS400 | |
| B | LYS126 | |
| B | LYS400 | |
| C | LYS126 | |
| C | LYS400 | |
| D | LYS126 | |
| D | LYS400 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O75874 |
| Chain | Residue | Details |
| A | LYS321 | |
| B | LYS321 | |
| C | LYS321 | |
| D | LYS321 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER389 | |
| B | SER389 | |
| C | SER389 | |
| D | SER389 |
