8KE7
Crystal structure of DNA binding and cleavage core of human topoisomerase 2-beta in a DNA binding-competent conformation
Functional Information from PROSITE/UniProt
site_id | PS00177 |
Number of Residues | 9 |
Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS |
Chain | Residue | Details |
A | LEU475-SER483 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:21778401 |
Chain | Residue | Details |
A | TYR821 | |
B | TYR821 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995 |
Chain | Residue | Details |
A | GLU477 | |
B | GLU477 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:21778401 |
Chain | Residue | Details |
A | ASP557 | |
A | ASP559 | |
B | ASP557 | |
B | ASP559 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | LYS505 | |
B | LYS678 | |
B | LYS739 | |
B | TRP947 | |
A | ASN508 | |
A | ARG677 | |
A | LYS678 | |
A | LYS739 | |
A | TRP947 | |
B | LYS505 | |
B | ASN508 | |
B | ARG677 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 |
Chain | Residue | Details |
A | TYR773 | |
B | TYR773 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | ARG820 | |
B | ARG820 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Important for DNA bending; intercalates between base pairs of target DNA |
Chain | Residue | Details |
A | ILE872 | |
B | ILE872 |
site_id | SWS_FT_FI8 |
Number of Residues | 14 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS595 | |
B | LYS630 | |
B | LYS641 | |
B | LYS671 | |
B | LYS707 | |
B | LYS1087 | |
A | LYS630 | |
A | LYS641 | |
A | LYS671 | |
A | LYS707 | |
A | LYS1087 | |
B | LYS595 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS600 | |
A | LYS638 | |
B | LYS600 | |
B | LYS638 |