Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8KC3

Cryo-EM structure of human C-terminally bound ATG9A-ATG2A-WIPI4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000139	cellular_component	Golgi membrane
A	0000407	cellular_component	phagophore assembly site
A	0000421	cellular_component	autophagosome membrane
A	0000423	biological_process	mitophagy
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005768	cellular_component	endosome
A	0005770	cellular_component	late endosome
A	0005776	cellular_component	autophagosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0006869	biological_process	lipid transport
A	0006914	biological_process	autophagy
A	0010936	biological_process	negative regulation of macrophage cytokine production
A	0016020	cellular_component	membrane
A	0017121	biological_process	plasma membrane phospholipid scrambling
A	0017128	molecular_function	phospholipid scramblase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0031966	cellular_component	mitochondrial membrane
A	0032688	biological_process	negative regulation of interferon-beta production
A	0034045	cellular_component	phagophore assembly site membrane
A	0034067	biological_process	protein localization to Golgi apparatus
A	0034497	biological_process	protein localization to phagophore assembly site
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0045087	biological_process	innate immune response
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0060349	biological_process	bone morphogenesis
A	0061709	biological_process	reticulophagy
A	0097060	cellular_component	synaptic membrane
A	0097300	biological_process	programmed necrotic cell death
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0000407	cellular_component	phagophore assembly site
B	0000421	cellular_component	autophagosome membrane
B	0000423	biological_process	mitophagy
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005768	cellular_component	endosome
B	0005770	cellular_component	late endosome
B	0005776	cellular_component	autophagosome
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0006869	biological_process	lipid transport
B	0006914	biological_process	autophagy
B	0010936	biological_process	negative regulation of macrophage cytokine production
B	0016020	cellular_component	membrane
B	0017121	biological_process	plasma membrane phospholipid scrambling
B	0017128	molecular_function	phospholipid scramblase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0031902	cellular_component	late endosome membrane
B	0031966	cellular_component	mitochondrial membrane
B	0032688	biological_process	negative regulation of interferon-beta production
B	0034045	cellular_component	phagophore assembly site membrane
B	0034067	biological_process	protein localization to Golgi apparatus
B	0034497	biological_process	protein localization to phagophore assembly site
B	0034727	biological_process	piecemeal microautophagy of the nucleus
B	0045087	biological_process	innate immune response
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0060349	biological_process	bone morphogenesis
B	0061709	biological_process	reticulophagy
B	0097060	cellular_component	synaptic membrane
B	0097300	biological_process	programmed necrotic cell death
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000407	cellular_component	phagophore assembly site
C	0000421	cellular_component	autophagosome membrane
C	0000423	biological_process	mitophagy
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005768	cellular_component	endosome
C	0005770	cellular_component	late endosome
C	0005776	cellular_component	autophagosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005802	cellular_component	trans-Golgi network
C	0006869	biological_process	lipid transport
C	0006914	biological_process	autophagy
C	0010936	biological_process	negative regulation of macrophage cytokine production
C	0016020	cellular_component	membrane
C	0017121	biological_process	plasma membrane phospholipid scrambling
C	0017128	molecular_function	phospholipid scramblase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0031902	cellular_component	late endosome membrane
C	0031966	cellular_component	mitochondrial membrane
C	0032688	biological_process	negative regulation of interferon-beta production
C	0034045	cellular_component	phagophore assembly site membrane
C	0034067	biological_process	protein localization to Golgi apparatus
C	0034497	biological_process	protein localization to phagophore assembly site
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0045087	biological_process	innate immune response
C	0055037	cellular_component	recycling endosome
C	0055038	cellular_component	recycling endosome membrane
C	0060349	biological_process	bone morphogenesis
C	0061709	biological_process	reticulophagy
C	0097060	cellular_component	synaptic membrane
C	0097300	biological_process	programmed necrotic cell death
D	0000045	biological_process	autophagosome assembly
D	0000407	cellular_component	phagophore assembly site
D	0000422	biological_process	autophagy of mitochondrion
D	0000425	biological_process	pexophagy
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006914	biological_process	autophagy
D	0008289	molecular_function	lipid binding
D	0009267	biological_process	cellular response to starvation
D	0019901	molecular_function	protein kinase binding
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
D	0034045	cellular_component	phagophore assembly site membrane
D	0034497	biological_process	protein localization to phagophore assembly site
D	0044804	biological_process	nucleophagy
D	0061723	biological_process	glycophagy
D	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
D	1901981	molecular_function	phosphatidylinositol phosphate binding
D	2000786	biological_process	positive regulation of autophagosome assembly
E	0000045	biological_process	autophagosome assembly
E	0000407	cellular_component	phagophore assembly site
E	0000422	biological_process	autophagy of mitochondrion
E	0000425	biological_process	pexophagy
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005811	cellular_component	lipid droplet
E	0006869	biological_process	lipid transport
E	0006914	biological_process	autophagy
E	0010508	biological_process	positive regulation of autophagy
E	0016020	cellular_component	membrane
E	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
E	0034045	cellular_component	phagophore assembly site membrane
E	0034727	biological_process	piecemeal microautophagy of the nucleus
E	0043495	molecular_function	membrane-membrane adaptor activity
E	0044232	cellular_component	organelle membrane contact site
E	0061709	biological_process	reticulophagy
E	0061723	biological_process	glycophagy
E	0061908	cellular_component	phagophore
E	0120009	biological_process	intermembrane lipid transfer
E	0120013	molecular_function	lipid transfer activity
E	2000786	biological_process	positive regulation of autophagosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEqKGLtgavGgvI

Chain	Residue	Details
E	GLY1876-ILE1890

site_id	PS00862
Number of Residues	34
Details	OX2_COVAL_FAD Oxygen oxidoreductases covalent FAD-binding site. PpvetaliNqrDLadaLldterslre...LaqpSGGH

Chain	Residue	Details
E	PRO1271-HIS1304

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	267
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	723
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WR4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	27
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"32610138","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33106659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JLP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	33
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	44
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	36
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	39
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	45
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Motif: {"description":"L/FRRG motif","evidences":[{"source":"UniProtKB","id":"Q9Y4P8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)