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8K9K

Full agonist-bound mu-type opioid receptor-G protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0016239biological_processpositive regulation of macroautophagy
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0046039biological_processGTP metabolic process
A0051301biological_processcell division
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0042597cellular_componentperiplasmic space
R0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIwTLCTMSVDRYIaV
ChainResidueDetails
RTHR155-VAL171

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2
RILE49

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphohistidine => ECO:0000250|UniProtKB:P62871
ChainResidueDetails
BHIS266

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
RASP166-ASN185
RLEU256-ARG279

site_idSWS_FT_FI4
Number of Residues24
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RILE107-LEU131

site_idSWS_FT_FI5
Number of Residues39
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RMET132-CYS142
RALA208-TRP230
RLEU307-THR314

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RLYS143-VAL165

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RALA186-MET207

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RGLU231-GLY255

site_idSWS_FT_FI9
Number of Residues26
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RILE280-ALA306

site_idSWS_FT_FI10
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P42866
ChainResidueDetails
RPHE315-TYR338

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P33535
ChainResidueDetails
RTYR168

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS353

224201

PDB entries from 2024-08-28

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