Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8K3L

SOD1 and Nanobody3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0000303	biological_process	response to superoxide
A	0001541	biological_process	ovarian follicle development
A	0001819	biological_process	positive regulation of cytokine production
A	0001890	biological_process	placenta development
A	0001895	biological_process	retina homeostasis
A	0002262	biological_process	myeloid cell homeostasis
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006749	biological_process	glutathione metabolic process
A	0006801	biological_process	superoxide metabolic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006915	biological_process	apoptotic process
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0007566	biological_process	embryo implantation
A	0007605	biological_process	sensory perception of sound
A	0007626	biological_process	locomotory behavior
A	0008089	biological_process	anterograde axonal transport
A	0008090	biological_process	retrograde axonal transport
A	0008217	biological_process	regulation of blood pressure
A	0008270	molecular_function	zinc ion binding
A	0008340	biological_process	determination of adult lifespan
A	0009408	biological_process	response to heat
A	0009410	biological_process	response to xenobiotic stimulus
A	0010467	biological_process	gene expression
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019226	biological_process	transmission of nerve impulse
A	0019228	biological_process	neuronal action potential
A	0019430	biological_process	removal of superoxide radicals
A	0030346	molecular_function	protein phosphatase 2B binding
A	0031267	molecular_function	small GTPase binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0032287	biological_process	peripheral nervous system myelin maintenance
A	0032839	cellular_component	dendrite cytoplasm
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032991	cellular_component	protein-containing complex
A	0033081	biological_process	regulation of T cell differentiation in thymus
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0040014	biological_process	regulation of multicellular organism growth
A	0042542	biological_process	response to hydrogen peroxide
A	0042554	biological_process	superoxide anion generation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043087	biological_process	regulation of GTPase activity
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045471	biological_process	response to ethanol
A	0046620	biological_process	regulation of organ growth
A	0046716	biological_process	muscle cell cellular homeostasis
A	0046872	molecular_function	metal ion binding
A	0048538	biological_process	thymus development
A	0048678	biological_process	response to axon injury
A	0050665	biological_process	hydrogen peroxide biosynthetic process
A	0050728	biological_process	negative regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0051087	molecular_function	protein-folding chaperone binding
A	0051093	biological_process	negative regulation of developmental process
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0060047	biological_process	heart contraction
A	0060052	biological_process	neurofilament cytoskeleton organization
A	0060087	biological_process	relaxation of vascular associated smooth muscle
A	0060088	biological_process	auditory receptor cell stereocilium organization
A	0070062	cellular_component	extracellular exosome
A	0072593	biological_process	reactive oxygen species metabolic process
A	0099610	biological_process	action potential initiation
A	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1904115	cellular_component	axon cytoplasm
A	2000242	biological_process	negative regulation of reproductive process
C	0000302	biological_process	response to reactive oxygen species
C	0000303	biological_process	response to superoxide
C	0001541	biological_process	ovarian follicle development
C	0001819	biological_process	positive regulation of cytokine production
C	0001890	biological_process	placenta development
C	0001895	biological_process	retina homeostasis
C	0002262	biological_process	myeloid cell homeostasis
C	0004784	molecular_function	superoxide dismutase activity
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006749	biological_process	glutathione metabolic process
C	0006801	biological_process	superoxide metabolic process
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006915	biological_process	apoptotic process
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0007566	biological_process	embryo implantation
C	0007605	biological_process	sensory perception of sound
C	0007626	biological_process	locomotory behavior
C	0008089	biological_process	anterograde axonal transport
C	0008090	biological_process	retrograde axonal transport
C	0008217	biological_process	regulation of blood pressure
C	0008270	molecular_function	zinc ion binding
C	0008340	biological_process	determination of adult lifespan
C	0009408	biological_process	response to heat
C	0009410	biological_process	response to xenobiotic stimulus
C	0010467	biological_process	gene expression
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019226	biological_process	transmission of nerve impulse
C	0019228	biological_process	neuronal action potential
C	0019430	biological_process	removal of superoxide radicals
C	0030346	molecular_function	protein phosphatase 2B binding
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0032287	biological_process	peripheral nervous system myelin maintenance
C	0032839	cellular_component	dendrite cytoplasm
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0032991	cellular_component	protein-containing complex
C	0033081	biological_process	regulation of T cell differentiation in thymus
C	0035234	biological_process	ectopic germ cell programmed cell death
C	0040014	biological_process	regulation of multicellular organism growth
C	0042542	biological_process	response to hydrogen peroxide
C	0042554	biological_process	superoxide anion generation
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043025	cellular_component	neuronal cell body
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043087	biological_process	regulation of GTPase activity
C	0043410	biological_process	positive regulation of MAPK cascade
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045471	biological_process	response to ethanol
C	0046620	biological_process	regulation of organ growth
C	0046716	biological_process	muscle cell cellular homeostasis
C	0046872	molecular_function	metal ion binding
C	0048538	biological_process	thymus development
C	0048678	biological_process	response to axon injury
C	0050665	biological_process	hydrogen peroxide biosynthetic process
C	0050728	biological_process	negative regulation of inflammatory response
C	0050766	biological_process	positive regulation of phagocytosis
C	0051087	molecular_function	protein-folding chaperone binding
C	0051093	biological_process	negative regulation of developmental process
C	0051881	biological_process	regulation of mitochondrial membrane potential
C	0060047	biological_process	heart contraction
C	0060052	biological_process	neurofilament cytoskeleton organization
C	0060087	biological_process	relaxation of vascular associated smooth muscle
C	0060088	biological_process	auditory receptor cell stereocilium organization
C	0070062	cellular_component	extracellular exosome
C	0072593	biological_process	reactive oxygen species metabolic process
C	0099610	biological_process	action potential initiation
C	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1904115	cellular_component	axon cytoplasm
C	2000242	biological_process	negative regulation of reproductive process
E	0000302	biological_process	response to reactive oxygen species
E	0000303	biological_process	response to superoxide
E	0001541	biological_process	ovarian follicle development
E	0001819	biological_process	positive regulation of cytokine production
E	0001890	biological_process	placenta development
E	0001895	biological_process	retina homeostasis
E	0002262	biological_process	myeloid cell homeostasis
E	0004784	molecular_function	superoxide dismutase activity
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006749	biological_process	glutathione metabolic process
E	0006801	biological_process	superoxide metabolic process
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006915	biological_process	apoptotic process
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0007566	biological_process	embryo implantation
E	0007605	biological_process	sensory perception of sound
E	0007626	biological_process	locomotory behavior
E	0008089	biological_process	anterograde axonal transport
E	0008090	biological_process	retrograde axonal transport
E	0008217	biological_process	regulation of blood pressure
E	0008270	molecular_function	zinc ion binding
E	0008340	biological_process	determination of adult lifespan
E	0009408	biological_process	response to heat
E	0009410	biological_process	response to xenobiotic stimulus
E	0010467	biological_process	gene expression
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019226	biological_process	transmission of nerve impulse
E	0019228	biological_process	neuronal action potential
E	0019430	biological_process	removal of superoxide radicals
E	0030346	molecular_function	protein phosphatase 2B binding
E	0031267	molecular_function	small GTPase binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0032287	biological_process	peripheral nervous system myelin maintenance
E	0032839	cellular_component	dendrite cytoplasm
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032991	cellular_component	protein-containing complex
E	0033081	biological_process	regulation of T cell differentiation in thymus
E	0035234	biological_process	ectopic germ cell programmed cell death
E	0040014	biological_process	regulation of multicellular organism growth
E	0042542	biological_process	response to hydrogen peroxide
E	0042554	biological_process	superoxide anion generation
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043025	cellular_component	neuronal cell body
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043087	biological_process	regulation of GTPase activity
E	0043410	biological_process	positive regulation of MAPK cascade
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0045471	biological_process	response to ethanol
E	0046620	biological_process	regulation of organ growth
E	0046716	biological_process	muscle cell cellular homeostasis
E	0046872	molecular_function	metal ion binding
E	0048538	biological_process	thymus development
E	0048678	biological_process	response to axon injury
E	0050665	biological_process	hydrogen peroxide biosynthetic process
E	0050728	biological_process	negative regulation of inflammatory response
E	0050766	biological_process	positive regulation of phagocytosis
E	0051087	molecular_function	protein-folding chaperone binding
E	0051093	biological_process	negative regulation of developmental process
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0060047	biological_process	heart contraction
E	0060052	biological_process	neurofilament cytoskeleton organization
E	0060087	biological_process	relaxation of vascular associated smooth muscle
E	0060088	biological_process	auditory receptor cell stereocilium organization
E	0070062	cellular_component	extracellular exosome
E	0072593	biological_process	reactive oxygen species metabolic process
E	0099610	biological_process	action potential initiation
E	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1904115	cellular_component	axon cytoplasm
E	2000242	biological_process	negative regulation of reproductive process
G	0000302	biological_process	response to reactive oxygen species
G	0000303	biological_process	response to superoxide
G	0001541	biological_process	ovarian follicle development
G	0001819	biological_process	positive regulation of cytokine production
G	0001890	biological_process	placenta development
G	0001895	biological_process	retina homeostasis
G	0002262	biological_process	myeloid cell homeostasis
G	0004784	molecular_function	superoxide dismutase activity
G	0005507	molecular_function	copper ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005759	cellular_component	mitochondrial matrix
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006749	biological_process	glutathione metabolic process
G	0006801	biological_process	superoxide metabolic process
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006915	biological_process	apoptotic process
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0007566	biological_process	embryo implantation
G	0007605	biological_process	sensory perception of sound
G	0007626	biological_process	locomotory behavior
G	0008089	biological_process	anterograde axonal transport
G	0008090	biological_process	retrograde axonal transport
G	0008217	biological_process	regulation of blood pressure
G	0008270	molecular_function	zinc ion binding
G	0008340	biological_process	determination of adult lifespan
G	0009408	biological_process	response to heat
G	0009410	biological_process	response to xenobiotic stimulus
G	0010467	biological_process	gene expression
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019226	biological_process	transmission of nerve impulse
G	0019228	biological_process	neuronal action potential
G	0019430	biological_process	removal of superoxide radicals
G	0030346	molecular_function	protein phosphatase 2B binding
G	0031267	molecular_function	small GTPase binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0032287	biological_process	peripheral nervous system myelin maintenance
G	0032839	cellular_component	dendrite cytoplasm
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0032991	cellular_component	protein-containing complex
G	0033081	biological_process	regulation of T cell differentiation in thymus
G	0035234	biological_process	ectopic germ cell programmed cell death
G	0040014	biological_process	regulation of multicellular organism growth
G	0042542	biological_process	response to hydrogen peroxide
G	0042554	biological_process	superoxide anion generation
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043025	cellular_component	neuronal cell body
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043087	biological_process	regulation of GTPase activity
G	0043410	biological_process	positive regulation of MAPK cascade
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0045471	biological_process	response to ethanol
G	0046620	biological_process	regulation of organ growth
G	0046716	biological_process	muscle cell cellular homeostasis
G	0046872	molecular_function	metal ion binding
G	0048538	biological_process	thymus development
G	0048678	biological_process	response to axon injury
G	0050665	biological_process	hydrogen peroxide biosynthetic process
G	0050728	biological_process	negative regulation of inflammatory response
G	0050766	biological_process	positive regulation of phagocytosis
G	0051087	molecular_function	protein-folding chaperone binding
G	0051093	biological_process	negative regulation of developmental process
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0060047	biological_process	heart contraction
G	0060052	biological_process	neurofilament cytoskeleton organization
G	0060087	biological_process	relaxation of vascular associated smooth muscle
G	0060088	biological_process	auditory receptor cell stereocilium organization
G	0070062	cellular_component	extracellular exosome
G	0072593	biological_process	reactive oxygen species metabolic process
G	0099610	biological_process	action potential initiation
G	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G	1904115	cellular_component	axon cytoplasm
G	2000242	biological_process	negative regulation of reproductive process

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
A	GLY44-THR54

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
A	GLY138-ILE149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:12963370, ECO:0000269\|PubMed:17548825

Chain	Residue	Details
A	HIS46
G	HIS46
G	HIS48
G	HIS120
A	HIS48
A	HIS120
C	HIS46
C	HIS48
C	HIS120
E	HIS46
E	HIS48
E	HIS120

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:20727846

Chain	Residue	Details
A	HIS63
E	HIS71
E	HIS80
E	ASP83
G	HIS63
G	HIS71
G	HIS80
G	ASP83
A	HIS71
A	HIS80
A	ASP83
C	HIS63
C	HIS71
C	HIS80
C	ASP83
E	HIS63

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:1463506, ECO:0000269\|PubMed:7002610, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
A	ALA1
C	ALA1
E	ALA1
G	ALA1

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
A	LYS3
G	LYS3
G	LYS9
G	LYS91
A	LYS9
A	LYS91
C	LYS3
C	LYS9
C	LYS91
E	LYS3
E	LYS9
E	LYS91

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER98
C	SER98
E	SER98
G	SER98

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER102
C	SER102
E	SER102
G	SER102

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P07632

Chain	Residue	Details
A	SER105
C	SER105
E	SER105
G	SER105

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
A	SER107
C	SER107
E	SER107
G	SER107

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:24140062

Chain	Residue	Details
A	LYS122
C	LYS122
E	LYS122
G	LYS122

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P08228

Chain	Residue	Details
A	LYS136
C	LYS136
E	LYS136
G	LYS136

site_id	SWS_FT_FI11
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:22496122

Chain	Residue	Details
A	CYS6
C	CYS6
E	CYS6
G	CYS6

site_id	SWS_FT_FI12
Number of Residues	8
Details	CROSSLNK: 1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33) => ECO:0000269\|PubMed:20600836

Chain	Residue	Details
A	TRP32
C	TRP32
E	TRP32
G	TRP32

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)