8K1V
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR8 | |
| A | GLY129-ASN158 | |
| B | MET1-THR8 | |
| B | GLY129-ASN158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU9-LEU29 | |
| A | ALA108-LEU128 | |
| A | MET159-SER179 | |
| A | LEU219-LEU239 | |
| B | LEU9-LEU29 | |
| B | ALA108-LEU128 | |
| B | MET159-SER179 | |
| B | LEU219-LEU239 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 174 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU30-ILE88 | |
| A | GLY102-LYS107 | |
| A | GLN180-PHE194 | |
| A | LEU208-PRO218 | |
| B | GLU30-ILE88 | |
| B | GLY102-LYS107 | |
| B | GLN180-PHE194 | |
| B | LEU208-PRO218 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 1 => ECO:0000255 |
| Chain | Residue | Details |
| A | THR89-PRO101 | |
| B | THR89-PRO101 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE195-ALA207 | |
| B | ILE195-ALA207 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P57789 |
| Chain | Residue | Details |
| A | THR93 | |
| B | ILE94 | |
| B | GLY95 | |
| B | TYR96 | |
| B | THR199 | |
| B | ILE200 | |
| B | GLY201 | |
| B | PHE202 | |
| A | ILE94 | |
| A | GLY95 | |
| A | TYR96 | |
| A | THR199 | |
| A | ILE200 | |
| A | GLY201 | |
| A | PHE202 | |
| B | THR93 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Forms a cation-pi interaction with protonated H-98, stabilizing the C-type inactivated state => ECO:0000269|PubMed:38630723 |
| Chain | Residue | Details |
| A | TRP78 | |
| B | TRP78 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: pH sensor => ECO:0000269|PubMed:38630723 |
| Chain | Residue | Details |
| A | HIS98 | |
| B | HIS98 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN53 | |
| B | ASN53 |
