8JXL

Human 3-methylcrotonyl-CoA carboxylase in MCCU state with MCoA

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GDsLmvMiAMKMehtIkS

Chain	Residue	Details
F	GLY671-SER688

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FMEMNTRL

Chain	Residue	Details
F	PHE333-LEU340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P24182

Chain	Residue	Details
F	ARG339
I	LYS495
K	LYS70
K	LYS495
C	ARG339
E	ARG339
H	ARG339
J	ARG339
L	ARG339
G	LYS70
G	LYS495
I	LYS70

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P24182

Chain	Residue	Details
F	LYS163
C	HIS255
C	HIS282
C	GLU322
E	LYS163
E	LYS205
E	GLY211
E	HIS255
E	HIS282
E	GLU322
H	LYS163
F	LYS205
H	LYS205
H	GLY211
H	HIS255
H	HIS282
H	GLU322
J	LYS163
J	LYS205
J	GLY211
J	HIS255
J	HIS282
F	GLY211
J	GLU322
L	LYS163
L	LYS205
L	GLY211
L	HIS255
L	HIS282
L	GLU322
F	HIS255
F	HIS282
F	GLU322
C	LYS163
C	LYS205
C	GLY211

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99MR8

Chain	Residue	Details
F	LYS237
J	LYS494
L	LYS237
L	LYS494
F	LYS494
C	LYS237
C	LYS494
E	LYS237
E	LYS494
H	LYS237
H	LYS494
J	LYS237

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99MR8

Chain	Residue	Details
F	LYS581
C	LYS581
E	LYS581
H	LYS581
J	LYS581
L	LYS581

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-biotinyllysine => ECO:0000255|PROSITE-ProRule:PRU01066

Chain	Residue	Details
F	LYS681
C	LYS681
E	LYS681
H	LYS681
J	LYS681
L	LYS681

---