Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8JR0

Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with TBAJ-587

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005886	cellular_component	plasma membrane
1	0006754	biological_process	ATP biosynthetic process
1	0008289	molecular_function	lipid binding
1	0015078	molecular_function	proton transmembrane transporter activity
1	0015986	biological_process	proton motive force-driven ATP synthesis
1	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
1	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
1	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
1	1902600	biological_process	proton transmembrane transport
2	0005886	cellular_component	plasma membrane
2	0006754	biological_process	ATP biosynthetic process
2	0008289	molecular_function	lipid binding
2	0015078	molecular_function	proton transmembrane transporter activity
2	0015986	biological_process	proton motive force-driven ATP synthesis
2	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
2	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
2	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
2	1902600	biological_process	proton transmembrane transport
3	0005886	cellular_component	plasma membrane
3	0006754	biological_process	ATP biosynthetic process
3	0008289	molecular_function	lipid binding
3	0015078	molecular_function	proton transmembrane transporter activity
3	0015986	biological_process	proton motive force-driven ATP synthesis
3	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
3	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
3	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
3	1902600	biological_process	proton transmembrane transport
4	0005886	cellular_component	plasma membrane
4	0006754	biological_process	ATP biosynthetic process
4	0008289	molecular_function	lipid binding
4	0015078	molecular_function	proton transmembrane transporter activity
4	0015986	biological_process	proton motive force-driven ATP synthesis
4	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
4	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
4	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
4	1902600	biological_process	proton transmembrane transport
5	0005886	cellular_component	plasma membrane
5	0006754	biological_process	ATP biosynthetic process
5	0008289	molecular_function	lipid binding
5	0015078	molecular_function	proton transmembrane transporter activity
5	0015986	biological_process	proton motive force-driven ATP synthesis
5	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
5	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
5	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
5	1902600	biological_process	proton transmembrane transport
6	0005886	cellular_component	plasma membrane
6	0006754	biological_process	ATP biosynthetic process
6	0008289	molecular_function	lipid binding
6	0015078	molecular_function	proton transmembrane transporter activity
6	0015986	biological_process	proton motive force-driven ATP synthesis
6	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
6	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
6	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
6	1902600	biological_process	proton transmembrane transport
7	0005886	cellular_component	plasma membrane
7	0006754	biological_process	ATP biosynthetic process
7	0008289	molecular_function	lipid binding
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
7	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	1902600	biological_process	proton transmembrane transport
8	0005886	cellular_component	plasma membrane
8	0006754	biological_process	ATP biosynthetic process
8	0008289	molecular_function	lipid binding
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
8	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	1902600	biological_process	proton transmembrane transport
9	0005886	cellular_component	plasma membrane
9	0006754	biological_process	ATP biosynthetic process
9	0008289	molecular_function	lipid binding
9	0015078	molecular_function	proton transmembrane transporter activity
9	0015986	biological_process	proton motive force-driven ATP synthesis
9	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
9	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
9	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
9	1902600	biological_process	proton transmembrane transport
a	0005886	cellular_component	plasma membrane
a	0006754	biological_process	ATP biosynthetic process
a	0015078	molecular_function	proton transmembrane transporter activity
a	0015986	biological_process	proton motive force-driven ATP synthesis
a	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
a	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
a	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
a	1902600	biological_process	proton transmembrane transport
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
b	0005886	cellular_component	plasma membrane
b	0006754	biological_process	ATP biosynthetic process
b	0009274	cellular_component	peptidoglycan-based cell wall
b	0015078	molecular_function	proton transmembrane transporter activity
b	0015986	biological_process	proton motive force-driven ATP synthesis
b	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
b	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0003824	molecular_function	catalytic activity
d	0005886	cellular_component	plasma membrane
d	0006754	biological_process	ATP biosynthetic process
d	0009274	cellular_component	peptidoglycan-based cell wall
d	0015078	molecular_function	proton transmembrane transporter activity
d	0015986	biological_process	proton motive force-driven ATP synthesis
d	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
d	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
d	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006754	biological_process	ATP biosynthetic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016887	molecular_function	ATP hydrolysis activity
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006754	biological_process	ATP biosynthetic process
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006754	biological_process	ATP biosynthetic process
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006754	biological_process	ATP biosynthetic process
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006754	biological_process	ATP biosynthetic process
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLASSS

Chain	Residue	Details
D	PRO355-SER364
A	PRO366-SER375

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITqEisEivgGAnA

Chain	Residue	Details
G	ILE287-ALA300

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLSLRLFGNI

Chain	Residue	Details
a	SER182-ILE191

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARQPeaqgrLfTpfFItvgLvE

Chain	Residue	Details
1	ALA40-GLU61

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
d	PHE4-PRO24
5	VAL57-ALA77
6	ILE5-GLY25
6	VAL57-ALA77
7	ILE5-GLY25
7	VAL57-ALA77
8	ILE5-GLY25
8	VAL57-ALA77
9	ILE5-GLY25
9	VAL57-ALA77
a	PHE86-VAL106
a	ILE129-TRP149
a	ILE191-ALA211
a	PHE219-PHE239
3	VAL57-ALA77
4	ILE5-GLY25
4	VAL57-ALA77
5	ILE5-GLY25

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Reversibly protonated during proton transport => ECO:0000255\|HAMAP-Rule:MF_01396

Chain	Residue	Details
1	GLU61
2	GLU61
3	GLU61
4	GLU61
5	GLU61
6	GLU61
7	GLU61
8	GLU61
9	GLU61

site_id	SWS_FT_FI3
Number of Residues	6
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269\|PubMed:20066036

Chain	Residue	Details
A	LYS499
B	LYS499
C	LYS499

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)