8JQR
Structure of human TRPV1 in complex with antagonist
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2436 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | MET1-ARG433 | |
| C | GLN498-SER510 | |
| C | ARG557-LYS571 | |
| C | ASN688-LYS839 | |
| D | MET1-ARG433 | |
| D | GLN498-SER510 | |
| D | ARG557-LYS571 | |
| D | ASN688-LYS839 | |
| A | GLN498-SER510 | |
| A | ARG557-LYS571 | |
| A | ASN688-LYS839 | |
| B | MET1-ARG433 | |
| B | GLN498-SER510 | |
| B | ARG557-LYS571 | |
| B | ASN688-LYS839 | |
| C | MET1-ARG433 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 560 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | ILE434-TYR454 | |
| B | GLU536-THR556 | |
| B | MET572-ILE599 | |
| B | VAL659-VAL687 | |
| C | ILE434-TYR454 | |
| C | TYR472-LEU497 | |
| C | TYR511-PHE531 | |
| C | GLU536-THR556 | |
| C | MET572-ILE599 | |
| C | VAL659-VAL687 | |
| D | ILE434-TYR454 | |
| A | TYR472-LEU497 | |
| D | TYR472-LEU497 | |
| D | TYR511-PHE531 | |
| D | GLU536-THR556 | |
| D | MET572-ILE599 | |
| D | VAL659-VAL687 | |
| A | TYR511-PHE531 | |
| A | GLU536-THR556 | |
| A | MET572-ILE599 | |
| A | VAL659-VAL687 | |
| B | ILE434-TYR454 | |
| B | TYR472-LEU497 | |
| B | TYR511-PHE531 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 308 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | TYR455-ASP471 | |
| D | TYR455-ASP471 | |
| D | SER532-LYS535 | |
| D | GLU600-ALA658 | |
| A | SER532-LYS535 | |
| A | GLU600-ALA658 | |
| B | TYR455-ASP471 | |
| B | SER532-LYS535 | |
| B | GLU600-ALA658 | |
| C | TYR455-ASP471 | |
| C | SER532-LYS535 | |
| C | GLU600-ALA658 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | ARG116 | |
| B | ARG116 | |
| B | LYS156 | |
| B | LYS161 | |
| B | ASN165 | |
| B | TYR200 | |
| B | GLU211 | |
| B | TYR511 | |
| B | THR550 | |
| B | ARG557 | |
| C | ARG116 | |
| A | LYS156 | |
| C | LYS156 | |
| C | LYS161 | |
| C | ASN165 | |
| C | TYR200 | |
| C | GLU211 | |
| C | TYR511 | |
| C | THR550 | |
| C | ARG557 | |
| D | ARG116 | |
| D | LYS156 | |
| A | LYS161 | |
| D | LYS161 | |
| D | ASN165 | |
| D | TYR200 | |
| D | GLU211 | |
| D | TYR511 | |
| D | THR550 | |
| D | ARG557 | |
| A | ASN165 | |
| A | TYR200 | |
| A | GLU211 | |
| A | TYR511 | |
| A | THR550 | |
| A | ARG557 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
| Chain | Residue | Details |
| A | ASP647 | |
| B | ASP647 | |
| C | ASP647 | |
| D | ASP647 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | SER117 | |
| B | SER117 | |
| C | SER117 | |
| D | SER117 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | THR145 | |
| A | THR371 | |
| B | THR145 | |
| B | THR371 | |
| C | THR145 | |
| C | THR371 | |
| D | THR145 | |
| D | THR371 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | SER502 | |
| B | SER502 | |
| C | SER502 | |
| D | SER502 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | THR705 | |
| B | THR705 | |
| C | THR705 | |
| D | THR705 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | SER775 | |
| A | SER821 | |
| B | SER775 | |
| B | SER821 | |
| C | SER775 | |
| C | SER821 | |
| D | SER775 | |
| D | SER821 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCE and PKC/PRKCZ => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | SER801 | |
| B | SER801 | |
| C | SER801 | |
| D | SER801 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| A | ASN604 | |
| B | ASN604 | |
| C | ASN604 | |
| D | ASN604 |
