8JLI
Cryo-EM structure of SV2A dimer in complex levetiracetam
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LsGVGiGGsipivfsYfsEflaqekR |
| Chain | Residue | Details |
| A | LEU264-ARG289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE170-LEU190 | |
| A | MET206-ALA226 | |
| A | CYS234-GLY254 | |
| A | LEU263-PHE283 | |
| A | TRP295-ILE315 | |
| A | VAL335-PRO355 | |
| A | LEU448-PHE468 | |
| A | PHE599-MET619 | |
| A | MET627-SER647 | |
| A | ILE652-LEU672 | |
| A | PHE686-VAL708 | |
| A | ALA713-LEU731 | |
| B | PHE170-LEU190 | |
| B | MET206-ALA226 | |
| B | CYS234-GLY254 | |
| B | LEU263-PHE283 | |
| B | TRP295-ILE315 | |
| B | VAL335-PRO355 | |
| B | LEU448-PHE468 | |
| B | PHE599-MET619 | |
| B | MET627-SER647 | |
| B | ILE652-LEU672 | |
| B | PHE686-VAL708 | |
| B | ALA713-LEU731 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 348 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO191-GLY205 | |
| A | TYR255-ARG262 | |
| A | PRO316-ARG334 | |
| A | PRO469-TYR598 | |
| A | GLU648-MET651 | |
| A | GLY709-LYS712 | |
| B | PRO191-GLY205 | |
| B | TYR255-ARG262 | |
| B | PRO316-ARG334 | |
| B | PRO469-TYR598 | |
| B | GLU648-MET651 | |
| B | GLY709-LYS712 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 270 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP227-GLN233 | |
| A | LEU284-SER294 | |
| A | GLU356-THR447 | |
| A | ASP620-ARG626 | |
| A | THR673-ALA685 | |
| A | LYS732-GLN742 | |
| B | ASP227-GLN233 | |
| B | LEU284-SER294 | |
| B | GLU356-THR447 | |
| B | ASP620-ARG626 | |
| B | THR673-ALA685 | |
| B | LYS732-GLN742 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER80 | |
| A | SER81 | |
| B | SER80 | |
| B | SER81 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | THR84 | |
| B | THR84 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JIS5 |
| Chain | Residue | Details |
| A | SER127 | |
| B | SER127 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02563 |
| Chain | Residue | Details |
| A | SER393 | |
| B | SER393 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9JIS5 |
| Chain | Residue | Details |
| A | TYR480 | |
| B | TYR480 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN498 | |
| A | ASN548 | |
| A | ASN573 | |
| B | ASN498 | |
| B | ASN548 | |
| B | ASN573 |
