8JKT

Crystal structure of feline aminopeptidase N ectodomain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002003	biological_process	angiotensin maturation
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016285	molecular_function	alanyl aminopeptidase activity
A	0042277	molecular_function	peptide binding
A	0043171	biological_process	peptide catabolic process
A	0070006	molecular_function	metalloaminopeptidase activity
B	0002003	biological_process	angiotensin maturation
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0016020	cellular_component	membrane
B	0016285	molecular_function	alanyl aminopeptidase activity
B	0042277	molecular_function	peptide binding
B	0043171	biological_process	peptide catabolic process
B	0070006	molecular_function	metalloaminopeptidase activity
C	0002003	biological_process	angiotensin maturation
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0016020	cellular_component	membrane
C	0016285	molecular_function	alanyl aminopeptidase activity
C	0042277	molecular_function	peptide binding
C	0043171	biological_process	peptide catabolic process
C	0070006	molecular_function	metalloaminopeptidase activity
D	0002003	biological_process	angiotensin maturation
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0016020	cellular_component	membrane
D	0016285	molecular_function	alanyl aminopeptidase activity
D	0042277	molecular_function	peptide binding
D	0043171	biological_process	peptide catabolic process
D	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	900
Details	Region: {"description":"Metalloprotease"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	680
Details	Region: {"description":"Interaction with FCoV and TGEV spike glycoprotein","evidences":[{"source":"PubMed","id":"9634079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9782265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15144","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P15144","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---