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8JKT

Crystal structure of feline aminopeptidase N ectodomain

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001618molecular_functionvirus receptor activity
A0004177molecular_functionaminopeptidase activity
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0030154biological_processcell differentiation
A0042277molecular_functionpeptide binding
A0043171biological_processpeptide catabolic process
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0070006molecular_functionmetalloaminopeptidase activity
B0001525biological_processangiogenesis
B0001618molecular_functionvirus receptor activity
B0004177molecular_functionaminopeptidase activity
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0030154biological_processcell differentiation
B0042277molecular_functionpeptide binding
B0043171biological_processpeptide catabolic process
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0070006molecular_functionmetalloaminopeptidase activity
C0001525biological_processangiogenesis
C0001618molecular_functionvirus receptor activity
C0004177molecular_functionaminopeptidase activity
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0030154biological_processcell differentiation
C0042277molecular_functionpeptide binding
C0043171biological_processpeptide catabolic process
C0046718biological_processsymbiont entry into host cell
C0046872molecular_functionmetal ion binding
C0070006molecular_functionmetalloaminopeptidase activity
D0001525biological_processangiogenesis
D0001618molecular_functionvirus receptor activity
D0004177molecular_functionaminopeptidase activity
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0008237molecular_functionmetallopeptidase activity
D0008270molecular_functionzinc ion binding
D0030154biological_processcell differentiation
D0042277molecular_functionpeptide binding
D0043171biological_processpeptide catabolic process
D0046718biological_processsymbiont entry into host cell
D0046872molecular_functionmetal ion binding
D0070006molecular_functionmetalloaminopeptidase activity
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHELAHQW
ChainResidueDetails
AVAL321-TRP330

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:9782265
ChainResidueDetails
AMET-62-SER-55
BMET-62-SER-55
CMET-62-SER-55
DMET-62-SER-55

site_idSWS_FT_FI2
Number of Residues92
DetailsTRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255
ChainResidueDetails
ALYS-54-VAL-31
BLYS-54-VAL-31
CLYS-54-VAL-31
DLYS-54-VAL-31

site_idSWS_FT_FI3
Number of Residues3736
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:9634079, ECO:0000269|PubMed:9782265
ChainResidueDetails
ATYR-30-SER904
BTYR-30-SER904
CTYR-30-SER904
DTYR-30-SER904

site_idSWS_FT_FI4
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095
ChainResidueDetails
AGLU325
BGLU325
CGLU325
DGLU325

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P15144
ChainResidueDetails
AGLY288
BGLY288
CGLY288
DGLY288

site_idSWS_FT_FI6
Number of Residues12
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095
ChainResidueDetails
AHIS324
DHIS324
DHIS328
DGLU347
AHIS328
AGLU347
BHIS324
BHIS328
BGLU347
CHIS324
CHIS328
CGLU347

site_idSWS_FT_FI7
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144
ChainResidueDetails
ATYR413
BTYR413
CTYR413
DTYR413

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Sulfotyrosine => ECO:0000255
ChainResidueDetails
ATYR112
ATYR355
BTYR112
BTYR355
CTYR112
CTYR355
DTYR112
DTYR355

site_idSWS_FT_FI9
Number of Residues32
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN-25
BASN21
BASN63
BASN170
BASN275
BASN563
BASN619
BASN677
CASN-25
CASN21
CASN63
AASN21
CASN170
CASN275
CASN563
CASN619
CASN677
DASN-25
DASN21
DASN63
DASN170
DASN275
AASN63
DASN563
DASN619
DASN677
AASN170
AASN275
AASN563
AASN619
AASN677
BASN-25

222415

PDB entries from 2024-07-10

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