8JI0
Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 1901982 | molecular_function | maltose binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| B | VAL292-CYS297 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| B | ASP435-VAL446 |
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO1962-ASN1979 |
| site_id | PS01209 |
| Number of Residues | 23 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C |
| Chain | Residue | Details |
| B | CYS126-CYS148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 93 |
| Details | Domain: {"description":"SRCR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 130 |
| Details | Region: {"description":"HKU1-CoV S protein-binding","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
