8JFL

PhK holoenzyme in active state, muscle isoform

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004689	molecular_function	phosphorylase kinase activity
A	0005516	molecular_function	calmodulin binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005964	cellular_component	phosphorylase kinase complex
A	0005975	biological_process	carbohydrate metabolic process
A	0005977	biological_process	glycogen metabolic process
A	0005980	biological_process	glycogen catabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0045819	biological_process	positive regulation of glycogen catabolic process
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005964	cellular_component	phosphorylase kinase complex
B	0005975	biological_process	carbohydrate metabolic process
B	0005977	biological_process	glycogen metabolic process
B	0005980	biological_process	glycogen catabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
C	0000166	molecular_function	nucleotide binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004689	molecular_function	phosphorylase kinase activity
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005964	cellular_component	phosphorylase kinase complex
C	0005975	biological_process	carbohydrate metabolic process
C	0005977	biological_process	glycogen metabolic process
C	0005980	biological_process	glycogen catabolic process
C	0006468	biological_process	protein phosphorylation
C	0007165	biological_process	signal transduction
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019899	molecular_function	enzyme binding
C	0050321	molecular_function	tau-protein kinase activity
C	0106310	molecular_function	protein serine kinase activity
E	0004689	molecular_function	phosphorylase kinase activity
E	0005516	molecular_function	calmodulin binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005964	cellular_component	phosphorylase kinase complex
E	0005975	biological_process	carbohydrate metabolic process
E	0005977	biological_process	glycogen metabolic process
E	0005980	biological_process	glycogen catabolic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0045819	biological_process	positive regulation of glycogen catabolic process
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005964	cellular_component	phosphorylase kinase complex
F	0005975	biological_process	carbohydrate metabolic process
F	0005977	biological_process	glycogen metabolic process
F	0005980	biological_process	glycogen catabolic process
F	0006091	biological_process	generation of precursor metabolites and energy
G	0000166	molecular_function	nucleotide binding
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004689	molecular_function	phosphorylase kinase activity
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005964	cellular_component	phosphorylase kinase complex
G	0005975	biological_process	carbohydrate metabolic process
G	0005977	biological_process	glycogen metabolic process
G	0005980	biological_process	glycogen catabolic process
G	0006468	biological_process	protein phosphorylation
G	0007165	biological_process	signal transduction
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019899	molecular_function	enzyme binding
G	0050321	molecular_function	tau-protein kinase activity
G	0106310	molecular_function	protein serine kinase activity
I	0004689	molecular_function	phosphorylase kinase activity
I	0005516	molecular_function	calmodulin binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005964	cellular_component	phosphorylase kinase complex
I	0005975	biological_process	carbohydrate metabolic process
I	0005977	biological_process	glycogen metabolic process
I	0005980	biological_process	glycogen catabolic process
I	0006091	biological_process	generation of precursor metabolites and energy
I	0045819	biological_process	positive regulation of glycogen catabolic process
J	0005515	molecular_function	protein binding
J	0005516	molecular_function	calmodulin binding
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005964	cellular_component	phosphorylase kinase complex
J	0005975	biological_process	carbohydrate metabolic process
J	0005977	biological_process	glycogen metabolic process
J	0005980	biological_process	glycogen catabolic process
J	0006091	biological_process	generation of precursor metabolites and energy
K	0000166	molecular_function	nucleotide binding
K	0004672	molecular_function	protein kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0004689	molecular_function	phosphorylase kinase activity
K	0005516	molecular_function	calmodulin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005964	cellular_component	phosphorylase kinase complex
K	0005975	biological_process	carbohydrate metabolic process
K	0005977	biological_process	glycogen metabolic process
K	0005980	biological_process	glycogen catabolic process
K	0006468	biological_process	protein phosphorylation
K	0007165	biological_process	signal transduction
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0019899	molecular_function	enzyme binding
K	0050321	molecular_function	tau-protein kinase activity
K	0106310	molecular_function	protein serine kinase activity
M	0004689	molecular_function	phosphorylase kinase activity
M	0005516	molecular_function	calmodulin binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005964	cellular_component	phosphorylase kinase complex
M	0005975	biological_process	carbohydrate metabolic process
M	0005977	biological_process	glycogen metabolic process
M	0005980	biological_process	glycogen catabolic process
M	0006091	biological_process	generation of precursor metabolites and energy
M	0045819	biological_process	positive regulation of glycogen catabolic process
N	0005515	molecular_function	protein binding
N	0005516	molecular_function	calmodulin binding
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005964	cellular_component	phosphorylase kinase complex
N	0005975	biological_process	carbohydrate metabolic process
N	0005977	biological_process	glycogen metabolic process
N	0005980	biological_process	glycogen catabolic process
N	0006091	biological_process	generation of precursor metabolites and energy
O	0000166	molecular_function	nucleotide binding
O	0004672	molecular_function	protein kinase activity
O	0004674	molecular_function	protein serine/threonine kinase activity
O	0004689	molecular_function	phosphorylase kinase activity
O	0005516	molecular_function	calmodulin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005964	cellular_component	phosphorylase kinase complex
O	0005975	biological_process	carbohydrate metabolic process
O	0005977	biological_process	glycogen metabolic process
O	0005980	biological_process	glycogen catabolic process
O	0006468	biological_process	protein phosphorylation
O	0007165	biological_process	signal transduction
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0019899	molecular_function	enzyme binding
O	0050321	molecular_function	tau-protein kinase activity
O	0106310	molecular_function	protein serine kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGVSSVVRrCihkptsqe..........YAVK

Chain	Residue	Details
C	LEU26-LYS49

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILL

Chain	Residue	Details
C	ILE146-LEU158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Region: {"description":"Calmodulin-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64649","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"UniProtKB","id":"P18688","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"UniProtKB","id":"P12798","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---