8JF7
Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| K | TYR192-HIS198 | |
| F | TYR221-HIS227 | |
| J | TYR208-HIS214 | |
| E | TYR237-HIS243 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 810 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | VAL24-HIS674 | |
| D | GLY770-HIS930 | |
| C | ARG19-GLN559 | |
| C | THR648-ASN812 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | TRP675-TYR695 | |
| D | TRP749-VAL769 | |
| D | PHE931-GLY951 | |
| C | SER560-LEU580 | |
| C | ILE631-TYR647 | |
| C | MET813-ILE833 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | GLU696-LEU748 | |
| B | ASN621-THR625 | |
| C | ASP581-THR602 | |
| C | ARG625-ARG630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN145 | |
| D | ASN565 | |
| D | ASN886 | |
| D | ASN264 | |
| D | ASN275 | |
| D | ASN285 | |
| D | ASN296 | |
| D | ASN300 | |
| D | ASN426 | |
| D | ASN439 | |
| D | ASN549 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| D | TYR1043 | |
| B | HIS128 | |
| B | GLU266 | |
| B | ASP282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| D | THR1042 | |
| D | GLY1044 | |
| A | ASP732 | |
| C | ARG523 | |
| C | SER688 | |
| C | ASP732 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY |
| Chain | Residue | Details |
| B | ARG518 | |
| A | ASN239 | |
| C | ASN61 | |
| C | ASN239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:24462099, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8 |
| Chain | Residue | Details |
| B | SER689 | |
| B | TYR730 | |
| C | ASN203 | |
| C | ASN368 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN614 | |
| C | ASN276 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN75 | |
| B | ASN340 | |
| B | ASN443 | |
| B | ASN444 | |
| B | ASN541 | |
| B | ASN687 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| B | TYR931 | |
| A | ASN771 | |
| C | ASN350 | |
| C | ASN771 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| B | THR930 | |
| B | GLY932 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN471 | |
| A | ASN491 | |
| A | ASN674 | |
| C | ASN471 | |
| C | ASN491 | |
| C | ASN674 |
