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8JEX

Cryo-EM structure of alpha-synuclein gS87 fibril

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004860molecular_functionprotein kinase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006469biological_processnegative regulation of protein kinase activity
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010517biological_processregulation of phospholipase activity
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0022898biological_processregulation of transmembrane transporter activity
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032410biological_processnegative regulation of transporter activity
A0032496biological_processresponse to lipopolysaccharide
A0032769biological_processnegative regulation of monooxygenase activity
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097435biological_processsupramolecular fiber organization
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903284biological_processpositive regulation of glutathione peroxidase activity
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001956biological_processpositive regulation of neurotransmitter secretion
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004860molecular_functionprotein kinase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006469biological_processnegative regulation of protein kinase activity
B0006631biological_processfatty acid metabolic process
B0006638biological_processneutral lipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0007006biological_processmitochondrial membrane organization
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0010040biological_processresponse to iron(II) ion
B0010517biological_processregulation of phospholipase activity
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0022898biological_processregulation of transmembrane transporter activity
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032410biological_processnegative regulation of transporter activity
B0032496biological_processresponse to lipopolysaccharide
B0032769biological_processnegative regulation of monooxygenase activity
B0032991cellular_componentprotein-containing complex
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0040012biological_processregulation of locomotion
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042417biological_processdopamine metabolic process
B0042775biological_processmitochondrial ATP synthesis coupled electron transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043030biological_processregulation of macrophage activation
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050806biological_processpositive regulation of synaptic transmission
B0050808biological_processsynapse organization
B0050812biological_processregulation of acyl-CoA biosynthetic process
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051402biological_processneuron apoptotic process
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060079biological_processexcitatory postsynaptic potential
B0060090molecular_functionmolecular adaptor activity
B0060291biological_processlong-term synaptic potentiation
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0061024biological_processmembrane organization
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0097435biological_processsupramolecular fiber organization
B0098794cellular_componentpostsynapse
B0099512cellular_componentsupramolecular fiber
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903284biological_processpositive regulation of glutathione peroxidase activity
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000149molecular_functionSNARE binding
G0000287molecular_functionmagnesium ion binding
G0000976molecular_functiontranscription cis-regulatory region binding
G0001774biological_processmicroglial cell activation
G0001921biological_processpositive regulation of receptor recycling
G0001956biological_processpositive regulation of neurotransmitter secretion
G0001963biological_processsynaptic transmission, dopaminergic
G0003779molecular_functionactin binding
G0004860molecular_functionprotein kinase inhibitor activity
G0005504molecular_functionfatty acid binding
G0005507molecular_functioncopper ion binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005543molecular_functionphospholipid binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005764cellular_componentlysosome
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0005938cellular_componentcell cortex
G0006469biological_processnegative regulation of protein kinase activity
G0006631biological_processfatty acid metabolic process
G0006638biological_processneutral lipid metabolic process
G0006644biological_processphospholipid metabolic process
G0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
G0007006biological_processmitochondrial membrane organization
G0007268biological_processchemical synaptic transmission
G0007269biological_processneurotransmitter secretion
G0008198molecular_functionferrous iron binding
G0008270molecular_functionzinc ion binding
G0008289molecular_functionlipid binding
G0008344biological_processadult locomotory behavior
G0009410biological_processresponse to xenobiotic stimulus
G0010040biological_processresponse to iron(II) ion
G0010517biological_processregulation of phospholipase activity
G0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
G0014048biological_processregulation of glutamate secretion
G0014059biological_processregulation of dopamine secretion
G0015629cellular_componentactin cytoskeleton
G0016020cellular_componentmembrane
G0016079biological_processsynaptic vesicle exocytosis
G0016082biological_processsynaptic vesicle priming
G0016234cellular_componentinclusion body
G0016491molecular_functionoxidoreductase activity
G0019894molecular_functionkinesin binding
G0022898biological_processregulation of transmembrane transporter activity
G0030424cellular_componentaxon
G0030426cellular_componentgrowth cone
G0030544molecular_functionHsp70 protein binding
G0030672cellular_componentsynaptic vesicle membrane
G0031092cellular_componentplatelet alpha granule membrane
G0031115biological_processnegative regulation of microtubule polymerization
G0031623biological_processreceptor internalization
G0031648biological_processprotein destabilization
G0032026biological_processresponse to magnesium ion
G0032410biological_processnegative regulation of transporter activity
G0032496biological_processresponse to lipopolysaccharide
G0032769biological_processnegative regulation of monooxygenase activity
G0032991cellular_componentprotein-containing complex
G0033138biological_processpositive regulation of peptidyl-serine phosphorylation
G0034341biological_processresponse to type II interferon
G0034599biological_processcellular response to oxidative stress
G0035493biological_processSNARE complex assembly
G0035543biological_processpositive regulation of SNARE complex assembly
G0040012biological_processregulation of locomotion
G0042393molecular_functionhistone binding
G0042416biological_processdopamine biosynthetic process
G0042417biological_processdopamine metabolic process
G0042775biological_processmitochondrial ATP synthesis coupled electron transport
G0042802molecular_functionidentical protein binding
G0042995cellular_componentcell projection
G0043014molecular_functionalpha-tubulin binding
G0043025cellular_componentneuronal cell body
G0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
G0043030biological_processregulation of macrophage activation
G0043065biological_processpositive regulation of apoptotic process
G0043066biological_processnegative regulation of apoptotic process
G0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
G0043524biological_processnegative regulation of neuron apoptotic process
G0043679cellular_componentaxon terminus
G0045202cellular_componentsynapse
G0045807biological_processpositive regulation of endocytosis
G0045920biological_processnegative regulation of exocytosis
G0045921biological_processpositive regulation of exocytosis
G0046872molecular_functionmetal ion binding
G0046928biological_processregulation of neurotransmitter secretion
G0048156molecular_functiontau protein binding
G0048168biological_processregulation of neuronal synaptic plasticity
G0048169biological_processregulation of long-term neuronal synaptic plasticity
G0048471cellular_componentperinuclear region of cytoplasm
G0048488biological_processsynaptic vesicle endocytosis
G0048489biological_processsynaptic vesicle transport
G0050729biological_processpositive regulation of inflammatory response
G0050806biological_processpositive regulation of synaptic transmission
G0050808biological_processsynapse organization
G0050812biological_processregulation of acyl-CoA biosynthetic process
G0051219molecular_functionphosphoprotein binding
G0051259biological_processprotein complex oligomerization
G0051262biological_processprotein tetramerization
G0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
G0051402biological_processneuron apoptotic process
G0051583biological_processdopamine uptake involved in synaptic transmission
G0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
G0051612biological_processnegative regulation of serotonin uptake
G0051621biological_processregulation of norepinephrine uptake
G0051622biological_processnegative regulation of norepinephrine uptake
G0055074biological_processcalcium ion homeostasis
G0060079biological_processexcitatory postsynaptic potential
G0060090molecular_functionmolecular adaptor activity
G0060291biological_processlong-term synaptic potentiation
G0060732biological_processpositive regulation of inositol phosphate biosynthetic process
G0060961molecular_functionphospholipase D inhibitor activity
G0061024biological_processmembrane organization
G0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
G0070555biological_processresponse to interleukin-1
G0070840molecular_functiondynein complex binding
G0071280biological_processcellular response to copper ion
G0071872biological_processcellular response to epinephrine stimulus
G0071902biological_processpositive regulation of protein serine/threonine kinase activity
G0097435biological_processsupramolecular fiber organization
G0098794cellular_componentpostsynapse
G0099512cellular_componentsupramolecular fiber
G1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
G1903136molecular_functioncuprous ion binding
G1903284biological_processpositive regulation of glutathione peroxidase activity
G1903285biological_processpositive regulation of hydrogen peroxide catabolic process
G1903421biological_processregulation of synaptic vesicle recycling
G1903426biological_processregulation of reactive oxygen species biosynthetic process
G1904377biological_processpositive regulation of protein localization to cell periphery
G1904715biological_processnegative regulation of chaperone-mediated autophagy
G1905606biological_processregulation of presynapse assembly
G1990000biological_processamyloid fibril formation
G2000377biological_processregulation of reactive oxygen species metabolic process
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0000149molecular_functionSNARE binding
H0000287molecular_functionmagnesium ion binding
H0000976molecular_functiontranscription cis-regulatory region binding
H0001774biological_processmicroglial cell activation
H0001921biological_processpositive regulation of receptor recycling
H0001956biological_processpositive regulation of neurotransmitter secretion
H0001963biological_processsynaptic transmission, dopaminergic
H0003779molecular_functionactin binding
H0004860molecular_functionprotein kinase inhibitor activity
H0005504molecular_functionfatty acid binding
H0005507molecular_functioncopper ion binding
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005543molecular_functionphospholipid binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005764cellular_componentlysosome
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005886cellular_componentplasma membrane
H0005938cellular_componentcell cortex
H0006469biological_processnegative regulation of protein kinase activity
H0006631biological_processfatty acid metabolic process
H0006638biological_processneutral lipid metabolic process
H0006644biological_processphospholipid metabolic process
H0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
H0007006biological_processmitochondrial membrane organization
H0007268biological_processchemical synaptic transmission
H0007269biological_processneurotransmitter secretion
H0008198molecular_functionferrous iron binding
H0008270molecular_functionzinc ion binding
H0008289molecular_functionlipid binding
H0008344biological_processadult locomotory behavior
H0009410biological_processresponse to xenobiotic stimulus
H0010040biological_processresponse to iron(II) ion
H0010517biological_processregulation of phospholipase activity
H0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
H0014048biological_processregulation of glutamate secretion
H0014059biological_processregulation of dopamine secretion
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016079biological_processsynaptic vesicle exocytosis
H0016082biological_processsynaptic vesicle priming
H0016234cellular_componentinclusion body
H0016491molecular_functionoxidoreductase activity
H0019894molecular_functionkinesin binding
H0022898biological_processregulation of transmembrane transporter activity
H0030424cellular_componentaxon
H0030426cellular_componentgrowth cone
H0030544molecular_functionHsp70 protein binding
H0030672cellular_componentsynaptic vesicle membrane
H0031092cellular_componentplatelet alpha granule membrane
H0031115biological_processnegative regulation of microtubule polymerization
H0031623biological_processreceptor internalization
H0031648biological_processprotein destabilization
H0032026biological_processresponse to magnesium ion
H0032410biological_processnegative regulation of transporter activity
H0032496biological_processresponse to lipopolysaccharide
H0032769biological_processnegative regulation of monooxygenase activity
H0032991cellular_componentprotein-containing complex
H0033138biological_processpositive regulation of peptidyl-serine phosphorylation
H0034341biological_processresponse to type II interferon
H0034599biological_processcellular response to oxidative stress
H0035493biological_processSNARE complex assembly
H0035543biological_processpositive regulation of SNARE complex assembly
H0040012biological_processregulation of locomotion
H0042393molecular_functionhistone binding
H0042416biological_processdopamine biosynthetic process
H0042417biological_processdopamine metabolic process
H0042775biological_processmitochondrial ATP synthesis coupled electron transport
H0042802molecular_functionidentical protein binding
H0042995cellular_componentcell projection
H0043014molecular_functionalpha-tubulin binding
H0043025cellular_componentneuronal cell body
H0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
H0043030biological_processregulation of macrophage activation
H0043065biological_processpositive regulation of apoptotic process
H0043066biological_processnegative regulation of apoptotic process
H0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
H0043524biological_processnegative regulation of neuron apoptotic process
H0043679cellular_componentaxon terminus
H0045202cellular_componentsynapse
H0045807biological_processpositive regulation of endocytosis
H0045920biological_processnegative regulation of exocytosis
H0045921biological_processpositive regulation of exocytosis
H0046872molecular_functionmetal ion binding
H0046928biological_processregulation of neurotransmitter secretion
H0048156molecular_functiontau protein binding
H0048168biological_processregulation of neuronal synaptic plasticity
H0048169biological_processregulation of long-term neuronal synaptic plasticity
H0048471cellular_componentperinuclear region of cytoplasm
H0048488biological_processsynaptic vesicle endocytosis
H0048489biological_processsynaptic vesicle transport
H0050729biological_processpositive regulation of inflammatory response
H0050806biological_processpositive regulation of synaptic transmission
H0050808biological_processsynapse organization
H0050812biological_processregulation of acyl-CoA biosynthetic process
H0051219molecular_functionphosphoprotein binding
H0051259biological_processprotein complex oligomerization
H0051262biological_processprotein tetramerization
H0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
H0051402biological_processneuron apoptotic process
H0051583biological_processdopamine uptake involved in synaptic transmission
H0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
H0051612biological_processnegative regulation of serotonin uptake
H0051621biological_processregulation of norepinephrine uptake
H0051622biological_processnegative regulation of norepinephrine uptake
H0055074biological_processcalcium ion homeostasis
H0060079biological_processexcitatory postsynaptic potential
H0060090molecular_functionmolecular adaptor activity
H0060291biological_processlong-term synaptic potentiation
H0060732biological_processpositive regulation of inositol phosphate biosynthetic process
H0060961molecular_functionphospholipase D inhibitor activity
H0061024biological_processmembrane organization
H0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
H0070555biological_processresponse to interleukin-1
H0070840molecular_functiondynein complex binding
H0071280biological_processcellular response to copper ion
H0071872biological_processcellular response to epinephrine stimulus
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0097435biological_processsupramolecular fiber organization
H0098794cellular_componentpostsynapse
H0099512cellular_componentsupramolecular fiber
H1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
H1903136molecular_functioncuprous ion binding
H1903284biological_processpositive regulation of glutathione peroxidase activity
H1903285biological_processpositive regulation of hydrogen peroxide catabolic process
H1903421biological_processregulation of synaptic vesicle recycling
H1903426biological_processregulation of reactive oxygen species biosynthetic process
H1904377biological_processpositive regulation of protein localization to cell periphery
H1904715biological_processnegative regulation of chaperone-mediated autophagy
H1905606biological_processregulation of presynapse assembly
H1990000biological_processamyloid fibril formation
H2000377biological_processregulation of reactive oxygen species metabolic process
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0000149molecular_functionSNARE binding
K0000287molecular_functionmagnesium ion binding
K0000976molecular_functiontranscription cis-regulatory region binding
K0001774biological_processmicroglial cell activation
K0001921biological_processpositive regulation of receptor recycling
K0001956biological_processpositive regulation of neurotransmitter secretion
K0001963biological_processsynaptic transmission, dopaminergic
K0003779molecular_functionactin binding
K0004860molecular_functionprotein kinase inhibitor activity
K0005504molecular_functionfatty acid binding
K0005507molecular_functioncopper ion binding
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005543molecular_functionphospholipid binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005764cellular_componentlysosome
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0005938cellular_componentcell cortex
K0006469biological_processnegative regulation of protein kinase activity
K0006631biological_processfatty acid metabolic process
K0006638biological_processneutral lipid metabolic process
K0006644biological_processphospholipid metabolic process
K0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
K0007006biological_processmitochondrial membrane organization
K0007268biological_processchemical synaptic transmission
K0007269biological_processneurotransmitter secretion
K0008198molecular_functionferrous iron binding
K0008270molecular_functionzinc ion binding
K0008289molecular_functionlipid binding
K0008344biological_processadult locomotory behavior
K0009410biological_processresponse to xenobiotic stimulus
K0010040biological_processresponse to iron(II) ion
K0010517biological_processregulation of phospholipase activity
K0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
K0014048biological_processregulation of glutamate secretion
K0014059biological_processregulation of dopamine secretion
K0015629cellular_componentactin cytoskeleton
K0016020cellular_componentmembrane
K0016079biological_processsynaptic vesicle exocytosis
K0016082biological_processsynaptic vesicle priming
K0016234cellular_componentinclusion body
K0016491molecular_functionoxidoreductase activity
K0019894molecular_functionkinesin binding
K0022898biological_processregulation of transmembrane transporter activity
K0030424cellular_componentaxon
K0030426cellular_componentgrowth cone
K0030544molecular_functionHsp70 protein binding
K0030672cellular_componentsynaptic vesicle membrane
K0031092cellular_componentplatelet alpha granule membrane
K0031115biological_processnegative regulation of microtubule polymerization
K0031623biological_processreceptor internalization
K0031648biological_processprotein destabilization
K0032026biological_processresponse to magnesium ion
K0032410biological_processnegative regulation of transporter activity
K0032496biological_processresponse to lipopolysaccharide
K0032769biological_processnegative regulation of monooxygenase activity
K0032991cellular_componentprotein-containing complex
K0033138biological_processpositive regulation of peptidyl-serine phosphorylation
K0034341biological_processresponse to type II interferon
K0034599biological_processcellular response to oxidative stress
K0035493biological_processSNARE complex assembly
K0035543biological_processpositive regulation of SNARE complex assembly
K0040012biological_processregulation of locomotion
K0042393molecular_functionhistone binding
K0042416biological_processdopamine biosynthetic process
K0042417biological_processdopamine metabolic process
K0042775biological_processmitochondrial ATP synthesis coupled electron transport
K0042802molecular_functionidentical protein binding
K0042995cellular_componentcell projection
K0043014molecular_functionalpha-tubulin binding
K0043025cellular_componentneuronal cell body
K0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
K0043030biological_processregulation of macrophage activation
K0043065biological_processpositive regulation of apoptotic process
K0043066biological_processnegative regulation of apoptotic process
K0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
K0043524biological_processnegative regulation of neuron apoptotic process
K0043679cellular_componentaxon terminus
K0045202cellular_componentsynapse
K0045807biological_processpositive regulation of endocytosis
K0045920biological_processnegative regulation of exocytosis
K0045921biological_processpositive regulation of exocytosis
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048156molecular_functiontau protein binding
K0048168biological_processregulation of neuronal synaptic plasticity
K0048169biological_processregulation of long-term neuronal synaptic plasticity
K0048471cellular_componentperinuclear region of cytoplasm
K0048488biological_processsynaptic vesicle endocytosis
K0048489biological_processsynaptic vesicle transport
K0050729biological_processpositive regulation of inflammatory response
K0050806biological_processpositive regulation of synaptic transmission
K0050808biological_processsynapse organization
K0050812biological_processregulation of acyl-CoA biosynthetic process
K0051219molecular_functionphosphoprotein binding
K0051259biological_processprotein complex oligomerization
K0051262biological_processprotein tetramerization
K0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
K0051402biological_processneuron apoptotic process
K0051583biological_processdopamine uptake involved in synaptic transmission
K0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
K0051612biological_processnegative regulation of serotonin uptake
K0051621biological_processregulation of norepinephrine uptake
K0051622biological_processnegative regulation of norepinephrine uptake
K0055074biological_processcalcium ion homeostasis
K0060079biological_processexcitatory postsynaptic potential
K0060090molecular_functionmolecular adaptor activity
K0060291biological_processlong-term synaptic potentiation
K0060732biological_processpositive regulation of inositol phosphate biosynthetic process
K0060961molecular_functionphospholipase D inhibitor activity
K0061024biological_processmembrane organization
K0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
K0070555biological_processresponse to interleukin-1
K0070840molecular_functiondynein complex binding
K0071280biological_processcellular response to copper ion
K0071872biological_processcellular response to epinephrine stimulus
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0097435biological_processsupramolecular fiber organization
K0098794cellular_componentpostsynapse
K0099512cellular_componentsupramolecular fiber
K1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
K1903136molecular_functioncuprous ion binding
K1903284biological_processpositive regulation of glutathione peroxidase activity
K1903285biological_processpositive regulation of hydrogen peroxide catabolic process
K1903421biological_processregulation of synaptic vesicle recycling
K1903426biological_processregulation of reactive oxygen species biosynthetic process
K1904377biological_processpositive regulation of protein localization to cell periphery
K1904715biological_processnegative regulation of chaperone-mediated autophagy
K1905606biological_processregulation of presynapse assembly
K1990000biological_processamyloid fibril formation
K2000377biological_processregulation of reactive oxygen species metabolic process
P0000122biological_processnegative regulation of transcription by RNA polymerase II
P0000149molecular_functionSNARE binding
P0000287molecular_functionmagnesium ion binding
P0000976molecular_functiontranscription cis-regulatory region binding
P0001774biological_processmicroglial cell activation
P0001921biological_processpositive regulation of receptor recycling
P0001956biological_processpositive regulation of neurotransmitter secretion
P0001963biological_processsynaptic transmission, dopaminergic
P0003779molecular_functionactin binding
P0004860molecular_functionprotein kinase inhibitor activity
P0005504molecular_functionfatty acid binding
P0005507molecular_functioncopper ion binding
P0005509molecular_functioncalcium ion binding
P0005515molecular_functionprotein binding
P0005543molecular_functionphospholipid binding
P0005576cellular_componentextracellular region
P0005615cellular_componentextracellular space
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005739cellular_componentmitochondrion
P0005764cellular_componentlysosome
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005886cellular_componentplasma membrane
P0005938cellular_componentcell cortex
P0006469biological_processnegative regulation of protein kinase activity
P0006631biological_processfatty acid metabolic process
P0006638biological_processneutral lipid metabolic process
P0006644biological_processphospholipid metabolic process
P0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
P0007006biological_processmitochondrial membrane organization
P0007268biological_processchemical synaptic transmission
P0007269biological_processneurotransmitter secretion
P0008198molecular_functionferrous iron binding
P0008270molecular_functionzinc ion binding
P0008289molecular_functionlipid binding
P0008344biological_processadult locomotory behavior
P0009410biological_processresponse to xenobiotic stimulus
P0010040biological_processresponse to iron(II) ion
P0010517biological_processregulation of phospholipase activity
P0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
P0014048biological_processregulation of glutamate secretion
P0014059biological_processregulation of dopamine secretion
P0015629cellular_componentactin cytoskeleton
P0016020cellular_componentmembrane
P0016079biological_processsynaptic vesicle exocytosis
P0016082biological_processsynaptic vesicle priming
P0016234cellular_componentinclusion body
P0016491molecular_functionoxidoreductase activity
P0019894molecular_functionkinesin binding
P0022898biological_processregulation of transmembrane transporter activity
P0030424cellular_componentaxon
P0030426cellular_componentgrowth cone
P0030544molecular_functionHsp70 protein binding
P0030672cellular_componentsynaptic vesicle membrane
P0031092cellular_componentplatelet alpha granule membrane
P0031115biological_processnegative regulation of microtubule polymerization
P0031623biological_processreceptor internalization
P0031648biological_processprotein destabilization
P0032026biological_processresponse to magnesium ion
P0032410biological_processnegative regulation of transporter activity
P0032496biological_processresponse to lipopolysaccharide
P0032769biological_processnegative regulation of monooxygenase activity
P0032991cellular_componentprotein-containing complex
P0033138biological_processpositive regulation of peptidyl-serine phosphorylation
P0034341biological_processresponse to type II interferon
P0034599biological_processcellular response to oxidative stress
P0035493biological_processSNARE complex assembly
P0035543biological_processpositive regulation of SNARE complex assembly
P0040012biological_processregulation of locomotion
P0042393molecular_functionhistone binding
P0042416biological_processdopamine biosynthetic process
P0042417biological_processdopamine metabolic process
P0042775biological_processmitochondrial ATP synthesis coupled electron transport
P0042802molecular_functionidentical protein binding
P0042995cellular_componentcell projection
P0043014molecular_functionalpha-tubulin binding
P0043025cellular_componentneuronal cell body
P0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
P0043030biological_processregulation of macrophage activation
P0043065biological_processpositive regulation of apoptotic process
P0043066biological_processnegative regulation of apoptotic process
P0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
P0043524biological_processnegative regulation of neuron apoptotic process
P0043679cellular_componentaxon terminus
P0045202cellular_componentsynapse
P0045807biological_processpositive regulation of endocytosis
P0045920biological_processnegative regulation of exocytosis
P0045921biological_processpositive regulation of exocytosis
P0046872molecular_functionmetal ion binding
P0046928biological_processregulation of neurotransmitter secretion
P0048156molecular_functiontau protein binding
P0048168biological_processregulation of neuronal synaptic plasticity
P0048169biological_processregulation of long-term neuronal synaptic plasticity
P0048471cellular_componentperinuclear region of cytoplasm
P0048488biological_processsynaptic vesicle endocytosis
P0048489biological_processsynaptic vesicle transport
P0050729biological_processpositive regulation of inflammatory response
P0050806biological_processpositive regulation of synaptic transmission
P0050808biological_processsynapse organization
P0050812biological_processregulation of acyl-CoA biosynthetic process
P0051219molecular_functionphosphoprotein binding
P0051259biological_processprotein complex oligomerization
P0051262biological_processprotein tetramerization
P0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
P0051402biological_processneuron apoptotic process
P0051583biological_processdopamine uptake involved in synaptic transmission
P0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
P0051612biological_processnegative regulation of serotonin uptake
P0051621biological_processregulation of norepinephrine uptake
P0051622biological_processnegative regulation of norepinephrine uptake
P0055074biological_processcalcium ion homeostasis
P0060079biological_processexcitatory postsynaptic potential
P0060090molecular_functionmolecular adaptor activity
P0060291biological_processlong-term synaptic potentiation
P0060732biological_processpositive regulation of inositol phosphate biosynthetic process
P0060961molecular_functionphospholipase D inhibitor activity
P0061024biological_processmembrane organization
P0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
P0070555biological_processresponse to interleukin-1
P0070840molecular_functiondynein complex binding
P0071280biological_processcellular response to copper ion
P0071872biological_processcellular response to epinephrine stimulus
P0071902biological_processpositive regulation of protein serine/threonine kinase activity
P0097435biological_processsupramolecular fiber organization
P0098794cellular_componentpostsynapse
P0099512cellular_componentsupramolecular fiber
P1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
P1903136molecular_functioncuprous ion binding
P1903284biological_processpositive regulation of glutathione peroxidase activity
P1903285biological_processpositive regulation of hydrogen peroxide catabolic process
P1903421biological_processregulation of synaptic vesicle recycling
P1903426biological_processregulation of reactive oxygen species biosynthetic process
P1904377biological_processpositive regulation of protein localization to cell periphery
P1904715biological_processnegative regulation of chaperone-mediated autophagy
P1905606biological_processregulation of presynapse assembly
P1990000biological_processamyloid fibril formation
P2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
HASP2
KHIS50
AASP2
AHIS50
HHIS50
PASP2
PHIS50
GASP2
GHIS50
BASP2
BHIS50
KASP2

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
HMET1
PMET1
GMET1
BMET1
KMET1
AMET1

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
HSER87
PSER87
GSER87
BSER87
KSER87
ASER87

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
HTYR125
PTYR125
GTYR125
BTYR125
KTYR125
ATYR125

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
HSER129
PSER129
GSER129
BSER129
KSER129
ASER129

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PDB entries from 2024-07-24

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