8JAR

Structure of CRL2APPBP2 bound with RxxGPAA degron (dimer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003777	molecular_function	microtubule motor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0006886	biological_process	intracellular protein transport
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0046907	biological_process	intracellular transport
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0003777	molecular_function	microtubule motor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0046907	biological_process	intracellular transport
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0001222	molecular_function	transcription corepressor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0016567	biological_process	protein ubiquitination
C	0030891	cellular_component	VCB complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0065003	biological_process	protein-containing complex assembly
C	0070449	cellular_component	elongin complex
C	0140958	biological_process	target-directed miRNA degradation
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0030163	biological_process	protein catabolic process
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0030891	cellular_component	VCB complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0044877	molecular_function	protein-containing complex binding
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	0001222	molecular_function	transcription corepressor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016567	biological_process	protein ubiquitination
G	0030891	cellular_component	VCB complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0070449	cellular_component	elongin complex
G	0140958	biological_process	target-directed miRNA degradation
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0000082	biological_process	G1/S transition of mitotic cell cycle
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005829	cellular_component	cytosol
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0016567	biological_process	protein ubiquitination
I	0019005	cellular_component	SCF ubiquitin ligase complex
I	0030163	biological_process	protein catabolic process
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0030891	cellular_component	VCB complex
I	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0044877	molecular_function	protein-containing complex binding
I	0097193	biological_process	intrinsic apoptotic signaling pathway
I	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA

Chain	Residue	Details
E	ILE718-ALA745

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS393
I	LYS393

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	THR661
I	THR661

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8) => ECO:0000269|PubMed:10092517, ECO:0000269|PubMed:10597293

Chain	Residue	Details
E	LYS689
C	SER111
I	LYS689
G	SER111

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