8J9K

Structure of basal beta-arrestin2

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001664	molecular_function	G protein-coupled receptor binding
C	0001932	biological_process	regulation of protein phosphorylation
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002029	biological_process	desensitization of G protein-coupled receptor signaling pathway
C	0002031	biological_process	G protein-coupled receptor internalization
C	0002092	biological_process	positive regulation of receptor internalization
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005905	cellular_component	clathrin-coated pit
C	0006366	biological_process	transcription by RNA polymerase II
C	0006897	biological_process	endocytosis
C	0007165	biological_process	signal transduction
C	0007179	biological_process	transforming growth factor beta receptor signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007600	biological_process	sensory perception
C	0007623	biological_process	circadian rhythm
C	0007628	biological_process	adult walking behavior
C	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
C	0009968	biological_process	negative regulation of signal transduction
C	0010628	biological_process	positive regulation of gene expression
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016323	cellular_component	basolateral plasma membrane
C	0016567	biological_process	protein ubiquitination
C	0019233	biological_process	sensory perception of pain
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0030139	cellular_component	endocytic vesicle
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031396	biological_process	regulation of protein ubiquitination
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0031410	cellular_component	cytoplasmic vesicle
C	0031623	biological_process	receptor internalization
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031691	molecular_function	alpha-1A adrenergic receptor binding
C	0031692	molecular_function	alpha-1B adrenergic receptor binding
C	0031701	molecular_function	angiotensin receptor binding
C	0031702	molecular_function	type 1 angiotensin receptor binding
C	0031748	molecular_function	D1 dopamine receptor binding
C	0031762	molecular_function	follicle-stimulating hormone receptor binding
C	0031826	molecular_function	type 2A serotonin receptor binding
C	0031859	molecular_function	platelet activating factor receptor binding
C	0032226	biological_process	positive regulation of synaptic transmission, dopaminergic
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0032695	biological_process	negative regulation of interleukin-12 production
C	0032715	biological_process	negative regulation of interleukin-6 production
C	0032720	biological_process	negative regulation of tumor necrosis factor production
C	0032967	biological_process	positive regulation of collagen biosynthetic process
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0034122	biological_process	negative regulation of toll-like receptor signaling pathway
C	0034260	biological_process	negative regulation of GTPase activity
C	0034392	biological_process	negative regulation of smooth muscle cell apoptotic process
C	0042699	biological_process	follicle-stimulating hormone signaling pathway
C	0042802	molecular_function	identical protein binding
C	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043197	cellular_component	dendritic spine
C	0043278	biological_process	response to morphine
C	0043422	molecular_function	protein kinase B binding
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0044877	molecular_function	protein-containing complex binding
C	0045211	cellular_component	postsynaptic membrane
C	0045953	biological_process	negative regulation of natural killer cell mediated cytotoxicity
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050965	biological_process	detection of temperature stimulus involved in sensory perception of pain
C	0051019	molecular_function	mitogen-activated protein kinase binding
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0051928	biological_process	positive regulation of calcium ion transport
C	0060090	molecular_function	molecular adaptor activity
C	0060252	biological_process	positive regulation of glial cell proliferation
C	0060326	biological_process	cell chemotaxis
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0071889	molecular_function	14-3-3 protein binding
C	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
C	0098926	biological_process	postsynaptic signal transduction
C	0098978	cellular_component	glutamatergic synapse
C	1902533	biological_process	positive regulation of intracellular signal transduction
C	1904037	biological_process	positive regulation of epithelial cell apoptotic process
C	1990763	molecular_function	arrestin family protein binding
C	2000475	biological_process	negative regulation of opioid receptor signaling pathway
C	2000476	biological_process	positive regulation of opioid receptor signaling pathway
C	2000573	biological_process	positive regulation of DNA biosynthetic process
C	2000727	biological_process	positive regulation of cardiac muscle cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLsFrKDL

Chain	Residue	Details
C	PHE62-LEU80

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q91YI4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Hydroxyproline; by PHD2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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