8J74

Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005307	molecular_function	choline:sodium symporter activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006836	biological_process	neurotransmitter transport
A	0007271	biological_process	synaptic transmission, cholinergic
A	0007274	biological_process	neuromuscular synaptic transmission
A	0008292	biological_process	acetylcholine biosynthetic process
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031594	cellular_component	neuromuscular junction
A	0031901	cellular_component	early endosome membrane
A	0033265	molecular_function	choline binding
A	0042734	cellular_component	presynaptic membrane
A	0043025	cellular_component	neuronal cell body
A	0043204	cellular_component	perikaryon
A	0045202	cellular_component	synapse
A	0055085	biological_process	transmembrane transport
A	0098793	cellular_component	presynapse
B	0005307	molecular_function	choline:sodium symporter activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006836	biological_process	neurotransmitter transport
B	0007271	biological_process	synaptic transmission, cholinergic
B	0007274	biological_process	neuromuscular synaptic transmission
B	0008292	biological_process	acetylcholine biosynthetic process
B	0015220	molecular_function	choline transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015871	biological_process	choline transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030672	cellular_component	synaptic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031594	cellular_component	neuromuscular junction
B	0031901	cellular_component	early endosome membrane
B	0033265	molecular_function	choline binding
B	0042734	cellular_component	presynaptic membrane
B	0043025	cellular_component	neuronal cell body
B	0043204	cellular_component	perikaryon
B	0045202	cellular_component	synapse
B	0055085	biological_process	transmembrane transport
B	0098793	cellular_component	presynapse

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	212
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	210
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---