Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8J74

Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0005307molecular_functioncholine:sodium symporter activity
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006814biological_processsodium ion transport
A0006836biological_processneurotransmitter transport
A0007271biological_processsynaptic transmission, cholinergic
A0007274biological_processneuromuscular synaptic transmission
A0008292biological_processacetylcholine biosynthetic process
A0015220molecular_functioncholine transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015871biological_processcholine transport
A0016020cellular_componentmembrane
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030672cellular_componentsynaptic vesicle membrane
A0031594cellular_componentneuromuscular junction
A0031901cellular_componentearly endosome membrane
A0033265molecular_functioncholine binding
A0042734cellular_componentpresynaptic membrane
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043204cellular_componentperikaryon
A0045202cellular_componentsynapse
A0055085biological_processtransmembrane transport
B0001701biological_processin utero embryonic development
B0005307molecular_functioncholine:sodium symporter activity
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0006814biological_processsodium ion transport
B0006836biological_processneurotransmitter transport
B0007271biological_processsynaptic transmission, cholinergic
B0007274biological_processneuromuscular synaptic transmission
B0008292biological_processacetylcholine biosynthetic process
B0015220molecular_functioncholine transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015871biological_processcholine transport
B0016020cellular_componentmembrane
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030672cellular_componentsynaptic vesicle membrane
B0031594cellular_componentneuromuscular junction
B0031901cellular_componentearly endosome membrane
B0033265molecular_functioncholine binding
B0042734cellular_componentpresynaptic membrane
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043204cellular_componentperikaryon
B0045202cellular_componentsynapse
B0055085biological_processtransmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues220
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AMET1-GLU6
AGLY70-GLY81
ASER147-SER164
AALA213-VAL237
AALA296-ASP317
ALEU398-TRP406
AGLN457-THR481
BMET1-GLU6
BGLY70-GLY81
BSER147-SER164
BALA213-VAL237
BALA296-ASP317
BLEU398-TRP406
BGLN457-THR481

site_idSWS_FT_FI2
Number of Residues520
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLY7-TRP27
AILE49-ASN69
ALEU82-PHE102
AMET126-PHE146
AVAL165-ALA185
ALEU192-VAL212
ATYR238-PHE258
APHE275-GLY295
AMET318-GLY338
AILE377-LEU397
ATYR407-VAL427
AVAL436-LEU456
ALEU482-PHE502
BGLY7-TRP27
BILE49-ASN69
BLEU82-PHE102
BMET126-PHE146
BVAL165-ALA185
BLEU192-VAL212
BTYR238-PHE258
BPHE275-GLY295
BMET318-GLY338
BILE377-LEU397
BTYR407-VAL427
BVAL436-LEU456
BLEU482-PHE502

site_idSWS_FT_FI3
Number of Residues366
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AARG28-ASP48
AALA103-ARG125
ATYR186-GLN191
AGLN259-SER274
AALA339-GLU376
ALYS428-ALA435
AGLU503-GLN580
BARG28-ASP48
BALA103-ARG125
BTYR186-GLN191
BGLN259-SER274
BALA339-GLU376
BLYS428-ALA435
BGLU503-GLN580

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN301
BASN301

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon