8J1H
Agonist1 and Ruthenium Red bound state of mTRPV4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 564 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| C | SER470-TYR490 | |
| D | ALA573-THR593 | |
| D | ILE609-LEU636 | |
| D | VAL694-VAL722 | |
| B | SER470-TYR490 | |
| B | TYR508-THR534 | |
| B | SER548-LEU568 | |
| B | ALA573-THR593 | |
| B | ILE609-LEU636 | |
| B | VAL694-VAL722 | |
| A | SER470-TYR490 | |
| C | TYR508-THR534 | |
| A | TYR508-THR534 | |
| A | SER548-LEU568 | |
| A | ALA573-THR593 | |
| A | ILE609-LEU636 | |
| A | VAL694-VAL722 | |
| C | SER548-LEU568 | |
| C | ALA573-THR593 | |
| C | ILE609-LEU636 | |
| C | VAL694-VAL722 | |
| D | SER470-TYR490 | |
| D | TYR508-THR534 | |
| D | SER548-LEU568 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 216 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| C | TYR491-ASP507 | |
| B | ALA569-GLU572 | |
| B | ASN637-THR665 | |
| B | LEU686-VAL693 | |
| A | TYR491-ASP507 | |
| A | ALA569-GLU572 | |
| A | ASN637-THR665 | |
| A | LEU686-VAL693 | |
| C | ALA569-GLU572 | |
| C | ASN637-THR665 | |
| C | LEU686-VAL693 | |
| D | TYR491-ASP507 | |
| D | ALA569-GLU572 | |
| D | ASN637-THR665 | |
| D | LEU686-VAL693 | |
| B | TYR491-ASP507 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| C | LYS535-GLY547 | |
| C | ARG594-LYS608 | |
| D | LYS535-GLY547 | |
| D | ARG594-LYS608 | |
| B | LYS535-GLY547 | |
| B | ARG594-LYS608 | |
| A | LYS535-GLY547 | |
| A | ARG594-LYS608 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 76 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:O35433 |
| Chain | Residue | Details |
| C | PHE666-MET685 | |
| D | PHE666-MET685 | |
| B | PHE666-MET685 | |
| A | PHE666-MET685 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9HBA0 |
| Chain | Residue | Details |
| C | LYS192 | |
| D | ARG248 | |
| B | LYS192 | |
| B | LYS197 | |
| B | ASN201 | |
| B | TYR236 | |
| B | ARG248 | |
| A | LYS192 | |
| A | LYS197 | |
| A | ASN201 | |
| A | TYR236 | |
| C | LYS197 | |
| A | ARG248 | |
| C | ASN201 | |
| C | TYR236 | |
| C | ARG248 | |
| D | LYS192 | |
| D | LYS197 | |
| D | ASN201 | |
| D | TYR236 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:A0A1D5PXA5 |
| Chain | Residue | Details |
| C | ARG249 | |
| A | ARG249 | |
| A | ASN296 | |
| A | LYS344 | |
| C | ASN296 | |
| C | LYS344 | |
| D | ARG249 | |
| D | ASN296 | |
| D | LYS344 | |
| B | ARG249 | |
| B | ASN296 | |
| B | LYS344 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
| Chain | Residue | Details |
| C | ASP682 | |
| D | ASP682 | |
| B | ASP682 | |
| A | ASP682 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by LYN => ECO:0000305|PubMed:12538589 |
| Chain | Residue | Details |
| C | TYR253 | |
| D | TYR253 | |
| B | TYR253 | |
| A | TYR253 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:16368742 |
| Chain | Residue | Details |
| C | ASN651 | |
| D | ASN651 | |
| B | ASN651 | |
| A | ASN651 |
