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8IYS

TUG891-bound FFAR4 in complex with Gq

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001818biological_processnegative regulation of cytokine production
R0004930molecular_functionG protein-coupled receptor activity
R0005504molecular_functionfatty acid binding
R0005764cellular_componentlysosome
R0005765cellular_componentlysosomal membrane
R0005768cellular_componentendosome
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0006954biological_processinflammatory response
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0008289molecular_functionlipid binding
R0008527molecular_functiontaste receptor activity
R0010008cellular_componentendosome membrane
R0010827biological_processregulation of glucose transmembrane transport
R0016020cellular_componentmembrane
R0030139cellular_componentendocytic vesicle
R0030154biological_processcell differentiation
R0032691biological_processnegative regulation of interleukin-1 beta production
R0032870biological_processcellular response to hormone stimulus
R0036321biological_processghrelin secretion
R0042277molecular_functionpeptide binding
R0042995cellular_componentcell projection
R0043066biological_processnegative regulation of apoptotic process
R0045444biological_processfat cell differentiation
R0045669biological_processpositive regulation of osteoblast differentiation
R0046879biological_processhormone secretion
R0050728biological_processnegative regulation of inflammatory response
R0050872biological_processwhite fat cell differentiation
R0050873biological_processbrown fat cell differentiation
R0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
R0060170cellular_componentciliary membrane
R0070094biological_processpositive regulation of glucagon secretion
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0090275biological_processnegative regulation of somatostatin secretion
R0090336biological_processpositive regulation of brown fat cell differentiation
R0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-THR45
RARG99-HIS112
RARG178-GLU204
RGLN290-ASP295

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RVAL46-ALA66
ALEU174
ATHR180
AASN268
AALA325

site_idSWS_FT_FI3
Number of Residues118
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RARG67-LEU77
RLEU134-ALA156
RSER226-LEU268
RASN317-GLY361

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RVAL78-VAL98

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RLEU113-SER133

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RVAL157-PHE177

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RILE205-ILE225

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RLEU269-ILE289

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RLEU296-LEU316

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:24817122
ChainResidueDetails
RTHR347
RTHR349

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:24817122
ChainResidueDetails
RSER350
RSER357

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:24817122
ChainResidueDetails
RSER360

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN21

222036

PDB entries from 2024-07-03

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