Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXO

Intermediate structure of mPIEZO1-S2472E

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005261	molecular_function	monoatomic cation channel activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0010831	biological_process	positive regulation of myotube differentiation
A	0016020	cellular_component	membrane
A	0031258	cellular_component	lamellipodium membrane
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0033625	biological_process	positive regulation of integrin activation
A	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0050982	biological_process	detection of mechanical stimulus
A	0071260	biological_process	cellular response to mechanical stimulus
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0140135	molecular_function	mechanosensitive monoatomic cation channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0010831	biological_process	positive regulation of myotube differentiation
B	0016020	cellular_component	membrane
B	0031258	cellular_component	lamellipodium membrane
B	0032420	cellular_component	stereocilium
B	0032437	cellular_component	cuticular plate
B	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
B	0033625	biological_process	positive regulation of integrin activation
B	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0050982	biological_process	detection of mechanical stimulus
B	0071260	biological_process	cellular response to mechanical stimulus
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0140135	molecular_function	mechanosensitive monoatomic cation channel activity
F	0005261	molecular_function	monoatomic cation channel activity
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006812	biological_process	monoatomic cation transport
F	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
F	0010831	biological_process	positive regulation of myotube differentiation
F	0016020	cellular_component	membrane
F	0031258	cellular_component	lamellipodium membrane
F	0032420	cellular_component	stereocilium
F	0032437	cellular_component	cuticular plate
F	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
F	0033625	biological_process	positive regulation of integrin activation
F	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042391	biological_process	regulation of membrane potential
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0050982	biological_process	detection of mechanical stimulus
F	0071260	biological_process	cellular response to mechanical stimulus
F	0098655	biological_process	monoatomic cation transmembrane transport
F	0140135	molecular_function	mechanosensitive monoatomic cation channel activity

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH

Chain	Residue	Details
F	TYR1680-HIS1686

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	222
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=18","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	672
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=19","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	81
Details	Transmembrane: {"description":"Helical; Name=20","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=21","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=22","evidences":[{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=23","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=24","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=25","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=26","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=27","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=28","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	129
Details	Transmembrane: {"description":"Helical; Name=29","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=30","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=31","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=32","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=33","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=34","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=35","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=36","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=37","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=38","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19144319","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)